This figure shows that the incorporation of three nucleotide analogues Carbovir-5’-Triphosphate (Car-TP), Entecavir-5’-Triphosphate (Ent-TP), and Ganciclovir-5’-Triphosphate (Gan-TP) by SARS-CoV-2 polymerase terminates the viral polymerase reaction. The reaction products were detected by MALDI-TOF mass spectrometry.
SARS-CoV-2, the coronavirus causing the global COVID-19 pandemic, uses a protein called polymerase to replicate its genome inside infected human cells. Terminating the polymerase reaction will stop the growth of the coronavirus, leading to its eradication by the human host’s immune system.
“In our efforts to help tackle this global emergency, we are very hopeful that the structural and chemical features of the molecules we identified, in correlation with their inhibitory activity to the SARS-CoV-2 polymerase, can be used as a guide to design and synthesize new compounds for the development of COVID-19 therapeutics,” says Ju.
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