Covid-19

An innovative stapled lipopeptides nasal spray could block Covid 19
via Dana Farber An innovative stapled lipopeptides nasal spray could block Covid 19 Stapled lipopeptides
Schematic and experimental design for MV@GEL as an intranasal mask to intercept viral aerosols and entrap virus. a The intranasal mask (MV@GEL) was composed of engineered cell-derived microsized vesicles (MV) with viral receptor and thermosensitive hydrogel with positive charges. It could be sprayed into the nasal cavity at room temperature and quickly transformed from the liquid state to the gel state at body temperature. The viral receptor of vesicles could help vesicles entrap the virus, and the thermosensitive hydrogel could prolong the retention time of vesicles in the nasal cavity. Once the negative viral aerosols were inhaled, the intranasal mask could perform the protective effect in the following steps: Step 1, the positively charged hydrogel could intercept the negatively charged viral aerosols presenting in airflow; Step 2, those viral aerosols could fuse with MV@GEL and release viruses into MV@GEL; Step 3, the embedded MV in MV@GEL could entrap those released viruses. b The protective effect of the intranasal mask was investigated from the following three aspects. 1. Mouse model: MV@GEL conferred strong protection against viral aerosol infection in the mouse nose and downstream lung; 2. Digital human nasal model: based on computerized tomography (CT) images of the human nasal cavity, computational fluid dynamics (CFD) simulation supported that viral aerosols could be intercepted in the human nasal cavity under MV@GEL protection; 3. Human respiratory tract model: connecting a realistic human nasal apparatus with human lung organoids and providing respiratory airflow by the pump; the human respiratory tract model was constructed and utilized to demonstrate the good performance of MV@GEL in protecting the lung organoids from viral aerosols. Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-44134-w
Protecting the respiratory tract from viral aerosols including Covid with a novel intranasal mask
Schematic and experimental design for MV@GEL as an intranasal mask to intercept viral aerosols and
A nanomaterials-based sensor detects flu and COVID-19 much more quickly than conventional tests. Dmitry Keeriv
New sensor could tell you in 10 seconds if it is Covid or the flu
A nanomaterials-based sensor detects flu and COVID-19 much more quickly than conventional tests. Dmitry Keeriv
An inhalable powder could protect lungs and airways from viral invasion including Covid and flu
Photo by Robina Weermeijer on Unsplash An inhalable powder could protect lungs and airways from
Hope for alleviating long Covid brain fog using a combination of a combination of guanfacine and N-acetylcysteine
via NewYork-Presbyterian Hope for alleviating long Covid brain fog using a combination of a combination
A safe, affordable variant-proof Covid drug in pill form
via Georgia State University A safe, affordable variant-proof Covid drug in pill form Scientists have
Drs. Richard Schwartz and Amy Baxter
Significantly reducing hospitalization and death from Covid-19 by twice-daily nasal irrigation
Drs. Richard Schwartz and Amy Baxter Significantly reducing hospitalization and death from Covid-19 by twice-daily
Dr. Natalia Freund CREDIT Tel Aviv University
Breakthrough: Antibodies that may make coronavirus vaccines unnecessary
Dr. Natalia Freund CREDIT: Tel Aviv University Breakthrough: Antibodies that may make coronavirus vaccines unnecessary
Early identification of COPD exacerbations can be managed via the myCOPD mobile app CREDIT my mHealth Ltd
Using an AI mobile phone app to accurately detect COVID-19 infection in people’s voices
Early identification of COPD exacerbations can be managed via the myCOPD mobile app CREDIT: my
Modeled SP1-77 binding site on various SARS-CoV-2 variants. (A) The potential footprint of SP1-77 on the modeled RBDs from different SARS-CoV-2 variants in a top view. The RBD was shown in surface representation in gray with the SP1-77 footprint highlighted in green and the mutations in each variant in blue. The Fv region of SP1-77 was shown in ribbon diagram in green. Most mutations on spike variants were not located at the SP1-77 footprint. (B) Side view of a selected panel from A. (C) Structural comparison of the SP1-77 binding interface among the RBDs of wildtype G614, Mu and Omicron variants. The conservative mutation Arg346Lys in Mu preserved the salt bridge between the residue 346 in the RBD and the SP1-77 Asp95. The mutations in Omicron variant reconfigured the local conformation near the N343-glycan, which is on the edge of SP1-77 footprint. The RBD was colored in gray, the SP1-77 heavy chain was colored in green and the light chain was colored in light green. Mutations in the Mu and Omicron variants were shown in stick and ball model in blue.
A new broadly neutralizing antibody neutralizes all known coronavirus variants
Modeled SP1-77 binding site on various SARS-CoV-2 variants. (A) The potential footprint of SP1-77 on
A wearable-informed machine learning algorithm may help detection of COVID-19 days earlier
via BMJ open A wearable-informed machine learning algorithm may help detection of COVID-19 days earlier
Coronavirus particles likely travel farther than once thought – how about 200 feet?
A study raises questions about how far droplets, like those that carry the virus that
A COVID breathalyzer for rapid mass screening
A SERS-based breathalyzer can distinguish volatile organic compounds in the breath of COVID-positive people in
Assessing personal exposure to SARS-CoV-2 with a wearable air sampling device
A wearable air sampler clip can monitor personal exposure to SARS-CoV-2. Credit: Adapted from Environmental
Using robots to tackle Covid-19 social distancing breaches
The robot is detecting non-compliance to social distancing norms, classifying non-compliant pedestrians into groups and