Salk Institute for Biological Studies

The Salk Institute for Biological Studies is an independent, non-profit, scientific research institute located in La Jolla, California.

Researchers can safely and effectively reverse the aging process in middle-aged and elderly mice

Activating brain, heart or other cells with ultrasound

Can a fast and portable test simultaneously detect and sequence SARS-CoV-2, influenza and other viruses?

Using the science of perception to keep innocent people out of jail

Living longer by eating less?

A combination of two previously studied osteoarthritis drugs reverses arthritis in rats

Can these experimental drugs reverse broader aging in humans as they appear to have done in mice?

Salk researchers show how two experimental Alzheimer’s drugs protect the brains of mice from other aspects of aging In mouse models of Alzheimer’s disease, the investigational drug candidates known as CMS121 and J147 improve memory and slow the degeneration of brain cells. Now, Salk researchers have shown how these compounds can also slow aging in

Can these experimental drugs reverse broader aging in humans as they appear to have done in mice?

Discovered: A gene that determines whether roots grow deep or shallow in the soil

Salk team’s finding will advance initiative to reduce atmospheric carbon through plants Hidden underground networks of plant roots snake through the earth foraging for nutrients and water, similar to a worm searching for food. Yet, the genetic and molecular mechanisms that govern which parts of the soil roots explore remain largely unknown. Now, Salk Institute

Discovered: A gene that determines whether roots grow deep or shallow in the soil

A new CRISPR-Cas9 therapy can suppress aging, enhance health and extend life span in mice

Putting the brakes on aging Aging is a leading risk factor for a number of debilitating conditions, including heart disease, cancer and Alzheimer’s disease, to name a few. This makes the need for anti-aging therapies all the more urgent. Now, Salk Institute researchers have developed a new gene therapy to help decelerate the aging process.

A new CRISPR-Cas9 therapy can suppress aging, enhance health and extend life span in mice

New methods to identify Alzheimer’s drug candidates that have anti-aging properties

Salk research focuses on the development of compounds that may protect against the diseases of aging, such as Alzheimer’s Old age is the greatest risk factor for many diseases, including Alzheimer’s disease (AD) and cancer. Geroprotectors are a recently identified class of anti-aging compounds. New Salk research has now identified a unique subclass of these

New methods to identify Alzheimer’s drug candidates that have anti-aging properties

Turning open wounds into skin through the alchemy of healing

Salk scientists develop new technique to heal large ulcers by reprogramming wound cells into skin cells Plastic surgery to treat large cutaneous ulcers, including those seen in people with severe burns, bedsores or chronic diseases such as diabetes, may someday be a thing of the past. Scientists at the Salk Institute have developed a technique

Turning open wounds into skin through the alchemy of healing

Single injection treats hemophilia B for life, in proof-of-concept study

The Salk approach, tested in a mouse model, points to cheaper and more effective treatments for humans For most people with hemophilia B, whose bodies can’t properly form blood clots, constant injections to replenish their clotting factors are a way of life. But now, Salk researchers have demonstrated in mice that hemophilia B can be

Single injection treats hemophilia B for life, in proof-of-concept study

Many forensic methods have never been scientifically validated – a major issue

MANY FORENSIC METHODS HAVE NEVER BEEN SCIENTIFICALLY VALIDATED, SCIENTISTS NOTE IN EDITORIAL Many of the “forensic science” methods commonly used in criminal cases and portrayed in popular police TV dramas have never been scientifically validated and may lead to unjust verdicts, according to an editorial in this week’s Proceedings of the National Academy of Sciences. The authors

Many forensic methods have never been scientifically validated – a major issue

Drugs for obesity might come from a molecule that gives energy-burning brown fat its identity

A protein found in brown fat, but not typical white fat, is key to how the energy-burning brown fat cells function While most fat cells in the human body store energy, everyone has a small subset of brown fat cells that do the opposite—burn energy and generate heat. Now, Salk researchers have discovered how the

Drugs for obesity might come from a molecule that gives energy-burning brown fat its identity

A new tool called CasRx targets RNA to correct a protein imbalance in cells from a dementia patient

Salk scientists create new molecular scissors to correct protein imbalance in cellular model of dementia Most people have heard of the CRISPR/Cas9 gene-editing technology, which acts as targeted molecular scissors to cut and replace disease-causing genes with healthy ones. But DNA is only part of the story; many genetic diseases are caused by problems with

A new tool called CasRx targets RNA to correct a protein imbalance in cells from a dementia patient

Systemic cellular reprogramming increases lifespan in mice by one third

Scientists have rolled back time for live mice through systemic cellular reprogramming, according to a study published December 15 in Cell. In mice carrying a mutation leading to premature aging, reprogramming of chemical marks in the genome, known as epigenetic marks, reduced many signs of aging in the mice and extended their lifespan on average

Systemic cellular reprogramming increases lifespan in mice by one third

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Salk Institute for Biological Studies Research

A brief history of tyrosine phosphorylation and its role in cancer research
In this interview, we talk to Tony Hunter about his research on the role of tyrosine phosphorylation in the cell cycle and cancer.
Why Are Rates Of Colon Cancer Surging Among Young Adults?
The incidence of colon cancer in young adults has surged in the past 30 years. getty. Recent studies have repeatedly indicated a growing surge in rates of colon cancer in young in ...
Autobahn Labs partners with Charles River to speed translation of academic research
Virtual biotech accelerator Autobahn Labs is amping up speed with a new Charles River Laboratories partnership in which the former will gain access to CRL's drug development capabilities, according | ...
Neuropeptides Found to Encode Danger in the Brain
Salk scientists have created methods to study neuropeptides, and discovered they control the brain’s fear response in mice.
Salk Professor Janelle Ayres named Howard Hughes Medical Institute Investigator
Salk Professor Janelle Ayres has been selected as a 2024 Howard Hughes Medical Institute (HHMI) Investigator in recognition of her influential work in immunology and microbiology and its applications ...

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Salk Institute for Biological Studies Discovery

Discovery in Ladakh could forever change search for alien life
Ladakh's harsh climate, characterised by high UV radiation, extreme temperature fluctuations, and limited water availability, makes it an ideal terrestrial analogue for Martian conditions.
Targeted Alzheimer's research and drug discovery
Researchers offer the first comprehensive ranking of the relative role and significance of every known gene and protein in the development of Alzheimer's Disease.
Autobahn Labs partners with Charles River to speed translation of academic research
Virtual biotech accelerator Autobahn Labs is amping up speed with a new Charles River Laboratories partnership in which the former will gain access to CRL's drug development capabilities, according | ...
Neuropeptides Found to Encode Danger in the Brain
Salk scientists have created methods to study neuropeptides, and discovered they control the brain’s fear response in mice.
Salk Professor Janelle Ayres named Howard Hughes Medical Institute Investigator
Salk Professor Janelle Ayres has been selected as a 2024 Howard Hughes Medical Institute (HHMI) Investigator in recognition of her influential work in immunology and microbiology and its applications ...