Super resolution microscopy is a technique that can see beyond the diffraction of light and provides unprecedented views of cells and their interior structures and organelles.
An EPFL team has developed a technique that can perform both 3D super resolution microscopy and fast 3D phase imaging in a single instrument.
This unique 4D microscope combines a sensitivity and high time resolution of phase imaging with the specifically and high spatial resolution of fluorescence microscopy. This allows the direct visualization and Analysis of subcellular structures in living cells without labeling.
These technical advances enable high-resolution visualization of the formation of pathological alpha-synuclein aggregates in hippocampal neurons. It is hoped that it will become a regular workhorse for neuroscience and biology.
Learn more: Super-resolution microscopy in both space and time
The Latest on: Super resolution microscopy
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The Latest on: Super resolution microscopy
- Testing how well biomarkers work: New fluorescence microscopy method can improve resolution down to the Ångström scaleon April 24, 2024 at 9:49 am
LMU researchers have developed a method to determine how reliably target proteins can be labeled using super-resolution fluorescence microscopy.
- Biophysics: Testing how well biomarkers workon April 23, 2024 at 5:00 pm
Researchers have developed a method to determine how reliably target proteins can be labeled using super-resolution fluorescence microscopy. LMU researchers have developed a method to determine how ...
- New super-resolution microscopy approach visualizes internal cell structures and clusters via selective plane activationon April 22, 2024 at 9:08 am
To study living organisms at ever smaller length scales, scientists must devise new techniques to overcome the so-called diffraction limit. This is the intrinsic limitation on a microscope's ability ...
- Super-Resolution Microscopy Can Be Super-Accessibleon April 8, 2024 at 5:00 pm
Here, GEN spoke with some of these players to learn how they are making super-resolution microscopy easier, cheaper, and more accessible than ever. When the Nobel Prize in Chemistry was awarded in ...
- Artificial intelligence enhances super-resolution microscopyon April 3, 2024 at 12:29 pm
Computational methods and algorithmic data processing are an important aspect of super-resolution microscopy, but a new approach to the task could offer a route to enhanced imaging. Generative AI is ...
- Artificial intelligence boosts super-resolution microscopyon March 27, 2024 at 5:01 pm
A fluorescence micrograph taken from the open BioSR super-resolution microscopy dataset (above and left of the dashed line) is compared to the same picture that has been reconstructed by the CVDM ...
- Super-Resolution Microscopy: Capturing the Nano-Worldon February 28, 2024 at 8:00 am
which makes imaging samples smaller than 200 nm almost impossible with conventional microscopy. Super resolution microscopy breaks through the diffraction limit, allowing scientists and researchers to ...
- Super-resolution microscopy harnesses digital display technologyon February 14, 2024 at 1:43 pm
In the ever-evolving realm of microscopy, recent years have witnessed ... system "DMD-3DSIM," combining digital display with super-resolution imaging, allowing scientists to see cellular ...
- Light Microscopyon August 17, 2023 at 12:37 am
Scientists can now use super-resolution microscopy to directly observe living subcellular structures and activities. In this piece, we explore the basics of three popular super-resolution techniques.
- Vutara VXL-Super-resolution microscopy workstationon July 17, 2023 at 7:10 am
The Vutara VXL comprehensive biological workstation from Bruker allows core facilities and separate investigators to seamlessly integrate super-resolution microscopy into their research.
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