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New test detects toxic prions in blood to screen for Mad Cow disease

New test detects toxic prions in blood to screen for Mad Cow disease

Variant Creutzfeldt-Jakob disease (vCJD), typical amyloid plaques, H&E (Photo credit: Wikipedia)

Variant Creutzfeldt-Jakob disease (vCJD), typical amyloid plaques, H&E (Photo credit: Wikipedia)

Could be used for screening donated blood for the presence of the vCJD agent

The first cases of mad cow disease in humans occurred in the late 1990s and are thought to be the consequence of eating contaminated beef products. Several cases of secondary infections caused by transfusions with blood from donors who developed vCJD have been reported, raising concerns about the safety of blood products. A new article describes an assay that can detect prions in blood samples from humans with vCJD and in animals at early stages of the incubation phase.

The authors say their “results represent substantial progress towards an applicable vCJD blood detection assay. Such assay could be used to identify vCJD infected but asymptomatic individuals and/or for screening donated blood for the presence of the vCJD agent.”

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