In addition to a potentially effective treatment for humans with HIV, the combination also shows potential to treat cats with leukemia.
A University of Minnesota research team featuring researchers from the Institute for Molecular Virology, School of Dentistry and Center for Drug Design has developed a new delivery system for a combination of two FDA approved drugs that may serve as an effective treatment for the human immunodeficiency virus (HIV).
The discovery, which allows for a combination of decitabine and gemcitabine to be delivered in pill form, marks a major step forward in patient feasibility for the drugs, which previously had been available solely via injection or intravenous therapy (IV).
The study, coauthored by Christine Clouser, Ph.D., Laurent Bonnac, Ph.D., Louis Mansky, Ph.D., and Steven Patterson, Ph.D., can be found “online first” in the journal Antiviral Chemistry & Chemotherapy.
“If you have a condition that requires you to take a medication everyday, as many patients with HIV do, you wouldn’t want to have to take that medication via daily injection,” said Steven Patterson, Ph.D., professor at the Center for Drug Design at the University of Minnesota. “This finding is a big step in demonstrating this treatment could be taken as a pill, similar to other HIV drugs, and is suitable for eventual clinical translation.”
University of Minnesota researchers first announced decitabine and gemcitabine could potentially combine to treat HIV in research published in August 2010. The drug combination was shown to work by lethal mutagenesis that could obliterate HIV by causing the virus to mutate to a point where it was no longer infectious. For some patients, HIV’s ability to quickly mutate and evolve can result in drug resistance. For patients who have developed resistance to currently available HIV treatments, the decitabine-gemcitabine drug combination could prove an effective alternative and secondary line of defense.
In addition to a potentially effective treatment for humans with HIV, the combination also shows potential to treat cats with leukemia.
The Latest Bing News on:
Decitabine and gemcitabine
- Bristol Myers: CHMP Recommends Approval Of Opdivo In Combination With Cisplatin And Gemcitabineon April 26, 2024 at 6:51 am
Bristol Myers Squibb (BMY) announced the Committee for Medicinal Products for Human Use or CHMP of the European Medicines Agency has ...
The Latest Google Headlines on:
Decitabine and gemcitabine
[google_news title=”” keyword=”Decitabine and gemcitabine” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
The Latest Bing News on:
HIV
- Healthcare providers are failing to protect the privacy of people living with HIV, watchdog warnson April 29, 2024 at 5:03 pm
Healthcare providers are failing to protect the privacy of people living with HIV, the UK’s data watchdog has warned. The Information Commissioner’s Office said it has been forced to hand fines worth thousands to organisations which have released the details of those living with HIV.
- From awareness to action: Mobilizing for HIV/AIDS awareness dayson April 29, 2024 at 6:22 am
National HIV/AIDS Awareness Days play a pivotal role in breaking down the stigma associated with HIV, fostering crucial conversations and actions aimed at ending the epidemic through targeted outreach and education across diverse communities.
The Latest Google Headlines on:
HIV
[google_news title=”” keyword=”HIV” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]