Scalable model supports patient-specific treatments, advanced study of blood disorders
A team led by researchers at Tufts University School of Engineering and the University of Pavia has reported development of the first three-dimensional tissue system that reproduces the complex structure and physiology of human bone marrow and successfully generates functional human platelets. Using a biomaterial matrix of porous silk, the new system is capable of producing platelets for future clinical use and also provides a laboratory tissue system to advance study of blood platelet diseases.
“There are many diseases where platelet production or function is impaired,” says Alessandra Balduini, M.D., research associate professor in the Department of Biomedical Engineering at Tufts, associate professor at the Department of Molecular Medicine at the University of Pavia and co-corresponding author on the paper. “New insight into the formation of platelets would have a major impact on patients and healthcare. In this tissue system, we can culture patient-derived megakaryocytes — the bone marrow cells that make platelets — and also endothelial cells, which are found in bone marrow and promote platelet production, to design patient-specific drug administration regimes.”
The new system can also provide an in vitro laboratory tissue system with which to study mechanisms of blood disease and to predict efficacy of new drugs–providing a more precise and less costly alternative to in vivo animal models.
Read more: 3-D engineered bone marrow makes functioning platelets
The Latest on: 3D tissue system
[google_news title=”” keyword=”3D tissue system” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: 3D tissue system
- Researchers develop new 3D printing for ultra-thin multi-material tubular structureson April 30, 2024 at 9:43 am
A novel 3D printing technology developed by Beihang University researchers was able to print multi-material tubular structures with a minimum wall thickness as thin as 50 micrometers and a minimum ...
- BMF launches biotechnology company to advance drug development through 3D BioChipson April 30, 2024 at 7:56 am
Boston Micro Fabrication (BMF) has set up a business headquartered in San Diego to develop and commercialise 3D BioChips through cultivating large-scale tissues in vitro to help accelerate new drug ...
- 3D Cell Culture Marketon April 28, 2024 at 10:16 pm
D Cell Culture Market an astounding US$ 3 billion by 2033, This trajectory represents a robust Compound Annual Growth Rate (CAGR) of 9%.
- IMcoMET Fights Skin Cancer With Micro 3D Printingon April 28, 2024 at 3:01 pm
Rotterdam-based startup IMcoMET is using micro 3D printing solutions from BMF to help in the fight against skin cancer.
- 3D Cell Culture Market is expected to reach revenue of USD 5.0 Bn by 2032, at 12.0% CAGR: Insights by Dimension Market Researchon April 23, 2024 at 8:25 am
Exploring the Dynamics of the 3D Cell Culture Market by an In-Depth Analysis of Growth Trajectories, Key Players, and Future TrendsNew Jersey, New York, Los Angeles, Austin, San Diego, Philadelphia, ...
- 3D engineered tissues as disease modelson April 15, 2024 at 5:00 pm
there is a paradigm shift towards 3D organ models as preclinical test systems. Despite the progress with excellent in vitro tissue models, the development of human disease models is still in its ...
- Tissue engineering and 3D printer replicate adult human earon April 1, 2024 at 5:00 pm
A replicated adult human ear that looks and feels natural has been developed by a team using a 3D printer and tissue engineering techniques. Pictured is the left-ear plastic scaffold that was created ...
- Top 15 3D Printing Companies in the USon March 28, 2024 at 1:32 pm
FXR314 shows promising signs after being tested on 3D-printed human tissue with Crohn’s disease ... The company’s Huffman Systems facilitate the manufacture and repair of flight and turbine ...
- World's First 3D-Printed Neural Tissue Grows And Functions Like a Human Brainon February 5, 2024 at 7:46 pm
Researchers have created the first functional 3D-printed brain tissue ... "Because we can print the tissue by design, we can have a defined system to look at how our human brain network operates ...
- Peek behind the paper: Three dimensional visualization and analysis of dendritic spines in human brain tissueon December 20, 2023 at 4:00 pm
Our study shows, for the first time, an optically acquired 3D image of dendritic ... to observe cell morphologies in their tissue context, democratizing structural–molecular–functional correlative ...
via Bing News