Johns Hopkins engineers have developed a method to prevent harmful viruses from entering the lungs, blocking the spread of COVID-19 and influenza with a nasal spray
What if preventing respiratory illnesses such as COVID-19 and influenza was as easy as a quick spritz of nasal spray every morning?
Numerous bacteria and viruses, including those that cause COVID-19 and influenza, enter the body through the lungs when people breathe, resulting in illness. Johns Hopkins engineers have created thin, thread-like strands of molecules called supramolecular filaments that are designed to be sprayed into the nose, blocking those harmful viruses from entering the lungs.
“The idea is that the filaments will work like a sponge to absorb the COVID-19 virus and other viruses before they have the chance to bind to cells in our airways. Even if the therapeutic can block the virus for an hour or two, that can be helpful when people must be in a public setting,” said research team leader Honggang Cui, core researcher at the Institute for NanoBioTechnology and associate professor of chemical and biomolecular engineering at Johns Hopkins Whiting School of Engineering.
“EVEN IF THE THERAPEUTIC CAN BLOCK THE VIRUS FOR AN HOUR OR TWO, THAT CAN BE HELPFUL WHEN PEOPLE MUST BE IN A PUBLIC SETTING.”
Honggang Cui
Core researcher at the Institute for NanoBioTechnology and associate professor at the Whiting School of Engineering
The team’s results appeared recently in Matter, and the work was done through a collaboration with Hongpeng Jia, assistant professor of surgery, and other researchers at Johns Hopkins School of Medicine.
The key to this approach is the way that the filaments carry a receptor called angiotensin converting enzyme-2, or ACE2. These receptors are also found in cells in the nasal lining, the lung surface, and small intestine, and have many biological roles, such as regulating blood pressure and inflammation. The novel coronavirus enters our bodies primarily through interactions with this receptor. The virus’s characteristic spike protein clicks into this receptor, much like a key going into a lock, allowing it to enter the cell and replicate. Once the virus is locked into the cell, it prevents the cell from executing its normal functions, leading to and exacerbating infections.
Researchers have long known that adding extra ACE2 into airways can block virus entry, essentially preventing the virus from binding with ACE2 in the lungs. However, since ACE2 has biological functions, simply delivering more ACE2 to the body may have unforeseeable complications. The research team’s newly engineered filament, called fACE2, serves as a decoy binding site for the virus, with each filament offering several receptors for the COVID-19 spike protein to attach to, and silences ACE2’s biological functions to avoid potential side effects.
“Our plan is that this would be administered as a nasal or oral spray, allowing it to be suspended in the lungs or settle on the surface of airways and lungs. When a person breathes in the COVID-19 virus, the virus will be fooled into binding to the decoy receptor and not the ACE2 receptors on cells,” Cui said.
And because the filaments attract SARS-CoV-2’s characteristic spike protein, it should work equally well on any current or future variants, the researchers predict.
The team tested its design in mouse models and found their filament not only was present in the rodents’ lungs up to 24 hours later, but also elicited no obvious damage to lungs structures or inflammation, suggesting that fACE2 may be retained in the lungs for a period of time, and is safe.
While the team’s original approach was to design a preventative therapeutic, they say that it also may have the potential to treat people with active COVID-19 infections by thwarting replication of newly acquired viruses.
“We think that fACE2 could also be used on other respiratory viruses that use the ACE2 receptor to infiltrate cells. The filament design is versatile and can be modified to carry various therapeutic proteins that target different receptors,” Jia said.
Original Article: A SIMPLE SPRAY COULD KEEP COVID-19 AWAY
More from: Whiting School of Engineering
The Latest Updates from Bing News
Go deeper with Bing News on:
Preventative therapeutic
- Novel bispecific antibodies show promise against evolving SARS-CoV-2 variants
By Hugo Francisco de SouzaIn a recent research paper uploaded to the bioRxiv preprint* server, researchers developed and tested novel bispecific antibodies (bsAbs) comprising both the N-terminal ...
- Sexual Violence Prevention Among Hundreds Of Job Cuts At ACC
All of the evidence points to investment in injury prevention reducing harm as being the best value ... to deliver the census from 2028 and beyond. NZ Government: Therapeutic Products Act To Be ...
- Scale Of ACC Cuts Could Impact Injury Prevention, Says Lobby Group
The scale of the announcement today by ACC that they will be shedding 390 jobs, including 29 from injury prevention has shocked and surprised the ACC Futures Coalition, who have expressed concern that ...
- Pharvaris Reports First Quarter 2024 Financial Results and Provides Business Update
RAPIDe-3, a global pivotal Phase 3 study of deucrictibant for the on-demand treatment of HAE attacks, currently enrollingEnd-of-Phase 2 meeting ...
- APOE4 gene linked to early onset Alzheimer's, target for therapeutic intervention
A study published in Nature Medicine delineates how APOE4 homozygosity distinctly accelerates Alzheimer's disease pathology and biomarkers from the age of 55, suggesting a unique form of the disease ...
Go deeper with Bing News on:
Supramolecular filaments
- Best 3D Printing Filament in 2024
James has been writing about technology for years but has loved it since the early 90s. While his main areas of expertise are maker tools -- 3D printers, vinyl cutters, paper printers, and laser ...
- Visualizing the Molecular Interaction of Formins with Actin Filaments
Actin achieves this by assembling into filaments, one actin molecule at a time. The proteins of the formin family are pivotal partners in this process: positioned at the filament end, formins ...
- 'One ring to rule them all': How actin filaments are assembled by formins
Actin achieves this by assembling into filaments, one actin molecule at a time. The proteins of the formin family are pivotal partners in this process: positioned at the filament end, formins ...
- 'One ring to rule them all': How actin filaments are assembled by formins
Researchers have visualized at the molecular level how formins bind to the ends of actin filaments. This allowed them to uncover how formins mediate the addition of new actin molecules to a ...
- Molecular biophysics articles from across Nature Portfolio
It seeks to explain biological function in terms of molecular structure, dynamics and organization, from single molecules to supramolecular ... ring formation and filament length determines ...