An investigational new heart failure drug could be poised to change the face of cardiology based on Hot Line results presented today at ESC Congress 2014.
Findings from the PARADIGM-HF trial, published simultaneously in the New England Journal of Medicine, “are extraordinarily powerful and compelling; they are destined to change the management of patients with chronic heart failure for years to come,” said Milton Packer, MD, co-primary author of the study from University of Texas Southwestern Medical Center, in Dallas, Texas USA.
“This really is an astonishing result and a real breakthrough for patients with heart failure,” added John McMurray, MD, the other co-primary author, from the University of Glasgow, UK.
The new agent, an angiotensin receptor-neprilysin inhibitor (ARNI) known as LCZ696, has already been granted Fast Track status by the United States Food and Drug Administration (FDA) – a designation which can expedite the review of new medicines intended to treat serious or life-threatening conditions. Fast Track designation also allows for rolling submission in the US, which Novartis said it expects to complete by the end of 2014. The company said it aims to file in Europe in early 2015.
“To say that we are excited is an understatement. We are absolutely thrilled,” said Dr. Packer.
“Given the survival advantage of LCZ696 over currently available drugs, once this drug becomes available, it would be difficult to understand why physicians would continue to use traditional angiotensin converting-enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) for the treatment of heart failure.”
The Latest on: Heart failure
[google_news title=”” keyword=”Heart failure” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Heart failure
- Rare genetic condition may offer protection from heart diseaseon April 30, 2024 at 3:56 pm
A rare genetic condition, known as growth hormone receptor deficiency (GHRD) or Laron syndrome, may protect against cardiovascular disease.
- URMC launches landmark study on heart failure treatmentson April 30, 2024 at 1:40 pm
Researchers at the University of Rochester Medical Center are launching a $27 million study on heart failure treatments.
- This Woman's Pregnancy Caused Her Heart Disease — Here's Everything You Need To Know About This Serious, Unpreventable Conditionon April 29, 2024 at 3:16 pm
"No one told me that the #1 cause of maternal mortality in the US is not only on the rise, but it is heart disease, specifically, cardiomyopathy or a weakened heart muscle. I never heard a word spoken ...
- Could vaping one time put you at a higher risk of heart failure?on April 29, 2024 at 2:38 pm
Could vaping just one time put you at higher risk of heart failure? More research is pointing to the dangers of e-cigarettes.
- Study in Haiti suggests early-onset heart failure is prevalent form of heart disease in low-income countrieson April 29, 2024 at 1:22 pm
Early-onset heart failure is alarmingly common in urban Haiti—over 15-fold higher than previously estimated—according to a study conducted by Weill Cornell Medicine researchers in partnership with the ...
- Heart Failure 2024 Congress Set to Address Gender Disparities and AI Integration in Cardiac Careon April 29, 2024 at 6:08 am
Join the Heart Failure 2024 Congress to explore AI in cardiac care, address gender disparities, and promote patient involvement in treatment.
- Gains in heart failure mortality have been erasedon April 29, 2024 at 1:47 am
Declines in heart failure-related mortality from 1999 to 2012 were entirely reversed from 2012 to 2021, according to a research letter published online April 24 in JAMA Cardiology.
- The Simple Measurement You Can Use to Calculate Your Heart Disease Risk, According to Cardiologistson April 28, 2024 at 4:25 pm
Your waist-to-hip ratio is a comparison of your waist measurement (or circumference) and your hip measurement (or circumference). High ratios show there is more fat around the middle, which has been ...
- Vaping, even once, may raise the risk of heart failure, study findson April 27, 2024 at 4:00 am
A new study indicates that people who have used a vape at any point in their lives are 19% more likely to experience heart failure compared to people who have never used them.
- Heart Failure Mortality Higher Now Than in 1999on April 26, 2024 at 12:41 pm
There needs to be a “focus on prevention of diseases and a redesign of how we deliver care,” says Marat Fudim.
via Bing News