This 3D printed vaccine patch gets a 10 times greater immune response than vaccine delivered into an arm muscle with a needle jab

While microneedle patches have been studied for decades, the work by Carolina and Stanford overcomes some past challenges: through 3D printing, the microneedles can be easily customized to develop various vaccine patches for flu, measles, hepatitis or COVID-19 vaccines.

While microneedle patches have been studied for decades, the work by Carolina and Stanford overcomes some past challenges: through 3D printing, the microneedles can be easily customized to develop various vaccine patches for flu, measles, hepatitis or COVID-19 vaccines.

This 3D printed vaccine patch gets a 10 times greater immune response than vaccine delivered into an arm muscle with a needle jab

Researchers from Carolina and Stanford University have developed a microneedle vaccine patch that outperforms needle jab to boost immunity.

Scientists at Stanford University and the University of North Carolina at Chapel Hill have created a 3D-printed vaccine patch that provides greater protection than a typical vaccine shot.

The trick is applying the vaccine patch directly to the skin, which is full of immune cells that vaccines target.

The resulting immune response from the vaccine patch was 10 times greater than a vaccine delivered into an arm muscle with a needle jab, according to a study conducted in animals and published by the team of scientists in the Proceedings of the National Academy of Sciences.

Considered a breakthrough are the 3D-printed microneedles lined up on a polymer patch and barely long enough to reach the skin to deliver vaccine.

“In developing this technology, we hope to set the foundation for even more rapid global development of vaccines, at lower doses, in a pain- and anxiety-free manner,” said lead study author and entrepreneur in 3D print technology Joseph M. DeSimone, professor of translational medicine and chemical engineering at Stanford University and professor emeritus at UNC-Chapel Hill.

The ease and effectiveness of a vaccine patch sets the course for a new way to deliver vaccines that are painless, less invasive than a shot with a needle and can be self-administered.

Study results show the vaccine patch generated a significant T-cell and antigen-specific antibody response that was 50 times greater than a subcutaneous injection delivered under the skin

That heightened immune response could lead to dose sparing, with a microneedle vaccine patch using a smaller dose to generate a similar immune response as a vaccine delivered with a needle and syringe.

While microneedle patches have been studied for decades, the work by Carolina and Stanford overcomes some past challenges: through 3D printing, the microneedles can be easily customized to develop various vaccine patches for flu, measles, hepatitis or COVID-19 vaccines.

Advantages of the vaccine patch

The COVID-19 pandemic has been a stark reminder of the difference made with timely vaccination. But getting a vaccine typically requires a visit to a clinic or hospital.

There a health care provider obtains a vaccine from a refrigerator or freezer, fills a syringe with the liquid vaccine formulation and injects it into the arm.

Although this process seems simple, there are issues that can hinder mass vaccination – from cold storage of vaccines to needing trained professionals who can give the shots.

Meanwhile, vaccine patches, which incorporate vaccine-coated microneedles that dissolve into the skin, could be shipped anywhere in the world without special handling and people can apply the patch themselves.

Moreover, the ease of using a vaccine patch may lead to higher vaccination rates.

How the patches are made

It’s generally a challenge to adapt microneedles to different vaccine types, said lead study author Shaomin Tian, a researcher in the Department of Microbiology and Immunology in the UNC School of Medicine.

“These issues, coupled with manufacturing challenges, have arguably held back the field of microneedles for vaccine delivery,” she said.

Most microneedle vaccines are fabricated with master templates to make molds. However, the molding of microneedles is not very versatile, and drawbacks include reduced needle sharpness during replication.

See Also
Nasal Congestion 111:365 (Photo credit: andreasnilsson1976)

“Our approach allows us to directly 3D print the microneedles, which gives us lots of design latitude for making the best microneedles from a performance and cost point-of-view,” Tian said.

The microneedle patches were 3D printed at Carolina using a CLIP prototype 3D printer that DeSimone invented and is produced by CARBON, a Silicon Valley company he co-founded.

The team of microbiologists and chemical engineers are continuing to innovate by formulating RNA vaccines, like the Pfizer and Moderna COVID-19 vaccines, into microneedle patches for future testing.

“One of the biggest lessons we’ve learned during the pandemic is that innovation in science and technology can make or break a global response,” DeSimone said. “Thankfully we have biotech and health care workers pushing the envelope for us all.”

 

Original Article: A 3D printed vaccine patch offers vaccination without a shot

More from: Stanford University | University of North Carolina at Chapel Hill

 

 

The Latest Updates from Bing News & Google News

Go deeper with Bing News on:
3D printed vaccine patch
  • Genzyme vet named to lead startup developing vaccines-in-a-patch
    on May 21, 2024 at 5:00 pm

    A Cambridge startup working on a shelf-stable skin patch to deliver vaccines and drugs has brought in new funding and a new leader as it prepares for important data readouts later this year.

  • microneedle patch
    on April 30, 2024 at 5:00 pm

    This is the promise of microneedle patches (MNP), which are essentially ... detail the construction and testing of a MNP printer, or microneedle vaccine printer (MVP) that can print dissolving ...

  • Painless Skin Patch Could Deliver Vaccines to Kids
    on April 29, 2024 at 11:14 pm

    More than 90% of 190 Gambian infants were protected from measles and all were protected from rubella after receiving a single vaccine dose through the patch, early trial results show. The patch ...

  • Painless Skin Patch Could Deliver Vaccines to Kids
    on April 29, 2024 at 5:00 pm

    More than 90% of infants received full protection from measles and 100% from rubella after receiving a single vaccine patch The patches bear microscopic needles that painlessly penetrate the skin ...

  • Patch to protect against measles in children shows promise
    on April 28, 2024 at 5:00 pm

    A vaccine patch could be a safe and effective alternative way to protect young children against measles, a trial in The Gambia suggests. The device - the size of a sticking plaster - is easier to ...

Go deeper with Google Headlines on:
3D printed vaccine patch

[google_news title=”” keyword=”3D printed vaccine patch” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]

Go deeper with Bing News on:
Vaccine patch
Go deeper with Google Headlines on:
Vaccine patch

[google_news title=”” keyword=”vaccine patch” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]

What's Your Reaction?
Don't Like it!
0
I Like it!
0
Scroll To Top