Smart nanomachines can detect and treat highly invasive cancer after surgery

Left: Primary tumor or overt metastasis Center: Center: Pre-metastatic niche Right: Post-surgical wound CREDIT 2021 Innovation Center of NanoMedicine

Left: Primary tumor or overt metastasis Center: Center: Pre-metastatic niche Right: Post-surgical wound

CREDIT: 2021 Innovation Center of NanoMedicine

Smart nanomachines can detect and treat highly invasive cancer after surgery

Summary:

  • Matrix metalloproteinases (MMPs) is an enzyme required for cancer cells to metastasize/invade, and cancer cells with higher MMP activity have higher metastasis ability and progress quickly.

In this study, we created polymersomes (smart nanomachines) that act specifically in tissues that overproduce MMPs, prevent cancer metastasis, and developed a method to remove residual tumor tissue that could not be visually confirmed after surgery.

  • We simultaneously loaded the cell division inhibitor colchicine and the MMP inhibitor marimastat into MMPs-responsive polymersomes as an enzymatically transformable nanomachine designed to achieve transformation following dePEGylation by cleavage of the inserted substrate peptide by MMPs. The effect on malignant tumors with high MMPs activity was evaluated.
  • During transformation, nanomachines with exposed guanidine residues easily penetrate into cells, and at the same time, by releasing the contained drugs, it exerts an anti-cancer effect.
  • Evaluating drug uptake using HT1080 cells derived from human fibrosarcoma that overproduce MMPs, studying pharmacokinetic and nano-bio interaction using a confocal laser scanning biomicroscope and evaluating metastasis inhibitory effect using triple-negative breast cancer transplantation model, the results were published in Advanced Materials (IF = 30.849 in 2021).

 

Original Article: Creating smart nanomachines to detect highly invasive cancer after surgery and prevent recurrence – cancer metastasis and recurrence prevention

More from: Innovation Center of NanoMedicine | University of Science and Technology of China

See Also

 

 

The Latest Updates from Bing News & Google News

Go deeper with Bing News on:
Smart nanomachines
  • 7 smart TV operating systems, ranked worst to best

    There are many factors that go into buying the best smart TV to suit your viewing needs. The screen type, size, processing power, refresh rate, and brightness, all play a role, as well they should.

  • Best Smart Home Devices of 2024

    Expertise Smart home devices, outdoors gadgets, smartphones, wearables, kid's tech, and some dabbling in 3D printing Credentials Covered the mobile and smart home tech space for the past five ...

  • The Best Smart Glasses for 2024

    Upgrade your eyewear with smart glasses that can function as cameras, headphones, and monitors. We've tested all the major models and have everything you need to know about specs, features ...

  • The best smart locks in 2024

    A smart lock is more than just a convenience; it can also give you peace of mind knowing that, if you're away from home, you'll know if someone enters your home. You can also give out temporary ...

  • Jean Smart was ‘nervous’ comics wouldn’t buy her as a standup in ‘Hacks’

    Jean Smart had never done standup comedy before she took on the role of the brilliant and biting comedian Deborah Vance in “Hacks.” In an interview with CNN’s Chris Wallace debuting Friday ...

Go deeper with Google Headlines on:
Smart nanomachines

[google_news title=”” keyword=”smart nanomachines” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]

Go deeper with Bing News on:
Polymersomes
  • Application of Nanoparticles in Cancer Treatment

    According to a recent review published by Prof. Changyang Gong’s research team at Sichuan University’s Department of Biotherapy, Cancer Center, and State Key Laboratory of Biotherapy, West ...

  • Advanced Manufacturing of Polymers & Soft Materials

    Synthesis and characterization of functional nano-biocolloids:- vesicles, liposomes, colloidosomes, polymersomes and polymer hydrogel microcapsules for drug delivery. Biodegradable shape memory ...

  • Ocular Drug Delivery

    Ocular Drug Delivery Systems Drug delivery systems research involves studies on polymeric micelles, polymersomes, other polymeric nanostructures, light activated liposomes and peptide conjugates for ...

  • Professor Laura Ferraiuolo

    Giuseppe Battaglia. My PhD entailed using biocompatible polymer nanoparticles (polymersomes) targeted across the blood-brain barrier as CNS drug delivery vehicles. I completed my first post-doc at the ...

  • Bridgette Budhlall

    Synthesis and characterization of functional nano-biocolloids:- vesicles, liposomes, colloidosomes, polymersomes and polymer hydrogel microcapsules for drug delivery. Biodegradable shape memory ...

Go deeper with Google Headlines on:
Polymersomes

[google_news title=”” keyword=”polymersomes” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]

What's Your Reaction?
Don't Like it!
0
I Like it!
0
Scroll To Top