Vessels grown from pluripotent stem cells able to function inside mice
Researchers at Johns Hopkins have coaxed stem cells into forming networks of new blood vessels in the laboratory, then successfully transplanted them into mice. The stem cells are made by reprogramming ordinary cells, so the new technique could potentially be used to make blood vessels genetically matched to individual patients and unlikely to be rejected by their immune systems, the investigators say. The results appear online this week in the Proceedings of the National Academy of Sciences.
“In demonstrating the ability to rebuild a microvascular bed in a clinically relevant manner, we have made an important step toward the construction of blood vessels for therapeutic use,” says Sharon Gerecht, Ph.D., an associate professor in the Johns Hopkins University Department of Chemical and Biomolecular Engineering, Physical Sciences–Oncology Center and Institute for NanoBioTechnology. “Our findings could yield more effective treatments for patients afflicted with burns, diabetic complications and other conditions in which vasculature function is compromised.”
Gerecht’s research group and others had previously grown blood vessels in the laboratory using stem cells, but barriers remain to efficiently producing the vessels and using them to treat patients.
For the current study, the group focused on streamlining the new growth process. Where other experiments used chemical cues to get stem cells to form cells of a single type, or to mature into a smorgasbord of cell types that the researchers would then sort through, graduate student Sravanti Kusuma devised a way to get the stem cells to form the two cell types needed to build new blood vessels — and only those types. “It makes the process quicker and more robust if you don’t have to sort through a lot of cells you don’t need to find the ones you do, or grow two batches of cells,” she says.
A second difference from previous experiments was that instead of using adult stem cells derived from cord blood or bone marrow to construct the network of vessels, Gerecht’s group teamed withLinzhao Cheng, Ph.D., a professor in the Institute for Cell Engineering, to use induced pluripotent stem cells as their starting point. Since this type of cell is made by reverse-engineering mature cells — from the skin or blood, for example — using it means that the resulting blood vessels could be tailor-made for specific patients, Kusuma says. “This is an elegant use of human induced pluripotent stem cells that can form multiple cell types within one kind of tissue or organ and have the same genetic background,” Cheng says. “This study showed that in addition to being able to form blood cells and neural cells as previously shown, blood-derived human induced pluripotent stem cells can also form multiple types of vascular network cells.”
The Latest Bing News on:
Custom-building New Blood Vessels
- Coordinating blood vessel activity may be associated with better brain performanceon April 26, 2024 at 6:11 am
Compared with computers, the brain can perform computations with a very low net energy supply. Yet our understanding surrounding how the biological brain manages energy is still incomplete. What is ...
- New experimental evidence unlocks a puzzle in vascular tissue engineeringon April 25, 2024 at 9:25 am
Angiogenesis is a process of forming hierarchical vascular networks in living tissues. Its complexity makes the controlled generation of blood vessels in laboratory conditions a highly challenging ...
- Could blood pressure be better controlled with new FDA-approved treatment? What to know.on April 24, 2024 at 4:00 am
Renal denervation at Heart Hospital of Austin helps Texas woman get her blood pressure better in control after 30 years of medications not working.
- Novel Cell Type in Blood Vessels Found Responsible for Vascular Growthon April 17, 2024 at 5:00 pm
A team of KIT researchers has now identified a new cell type in blood vessels responsible for vascular growth. This discovery may allow for novel therapeutic strategies to treat ischemic ...
- Molecular code stimulates pioneer cells to build blood vessels in the bodyon April 16, 2024 at 5:01 pm
A team of KIT researchers has now identified a new cell type in blood vessels responsible for vascular growth. This discovery may allow for novel therapeutic strategies to treat ischemic ...
- Blood Vessels News and Researchon April 9, 2024 at 5:00 pm
A new study conducted in mice traces how obesity and a high-fat diet may accelerate aging in the blood vessels that supply blood to the brain. Experts from NYU Langone Heart are presenting their ...
- BLOOD VESSELSon April 9, 2024 at 3:57 pm
Scientists have developed a new smart needle with a tiny camera that allows surgeons to see at-risk blood vessels and avoid injuring them, an advance that may make brain surgery safer. Doctors say ...
- Yale researchers are bioengineering blood vessels to treat congenital heart defectson April 7, 2024 at 5:02 pm
Yale researchers are exploring a new approach to treat a potentially deadly ... Qyang’s group hopes to use the iPSCs to generate the cellular building blocks that are essential components of blood ...
- New research explains how brain blood vessels are formedon April 2, 2024 at 4:59 pm
Contrary to the generally accepted idea that blood vessels form in a similar way throughout the body, Giel Schevenels and colleagues have discovered that those irrigating the brain obey different ...
- Page settingson March 3, 2024 at 3:53 pm
Broken blood vessels, also known as spider veins ... but watching the runners battle over the last mile inspired him to take up a new challenge. Seeing him embrace competitive sports for years ...
The Latest Google Headlines on:
Custom-building New Blood Vessels
[google_news title=”” keyword=”Custom-building New Blood Vessels” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
The Latest Bing News on:
Human induced pluripotent stem cells
- Device improves stem cell generation and chance for accessible Alzheimer’s cell therapyon April 24, 2024 at 1:58 pm
Using a specially-designed microfluidic device, the research team have developed an unprecedented and speedier approach to reprogramming human skin cells into induced pluripotent stem cells (iPSCs ...
- New device improves stem cell generation and chance for accessible Alzheimer's cell therapyon April 24, 2024 at 12:11 pm
Researchers in Sweden say they have improved on a technique for converting regular skin cells into neural stem cells—an advance that they say helps close the gap for accessible personalized cell-based ...
- Induced Pluripotent Stem Cell (iPSC) Market Size Projected to Surge $5.2 Billion Growth by 2033, Exhibit a CAGR of 9.6%on April 24, 2024 at 5:00 am
Induced pluripotent stem cell (iPSC) market size from USD 2.1 billion in 2023 to USD 5.2 billion in 10 years. The growing incidence of cancer drive the market's growthNewark, April 24, 2024 (GLOBE ...
- Induced pluripotent stem cells articles from across Nature Portfolioon April 15, 2024 at 5:00 pm
Induced pluripotent stem cells (iPSCs) are pluripotent stem cells generated from adult cells by reprogramming. iPSCs have the same properties as embryonic stem cells, and therefore self-renew and ...
- Stem Cells Newson April 10, 2024 at 5:00 pm
Human Stem Cells Coaxed to Mimic the Very Early Central ... and pain-free method to generate canine-induced pluripotent stem cells (iPSCs). They identified six reprogramming genes that can boost ...
- Advances in Induced Pluripotent Stem Cell Researchon April 7, 2024 at 5:00 pm
Induced pluripotent stem cells (iPSCs) are capable of differentiating into all somatic cells of the body, whilst being infinitely expandable in culture. These characteristics make iPSCs not only ...
- New technique for Parkinson's stem cell brain repair brings promise for patientson March 19, 2024 at 2:10 pm
More information: Giulia Comini et al, Survival and maturation of human induced pluripotent stem cell-derived dopaminergic progenitors in the Parkinsonian rat brain is enhanced by transplantation ...
- Transforming biomedical research and precision medicine through induced pluripotent stem cell innovationon February 14, 2024 at 8:58 am
The limiting factor has been the availability of viable human cells needed to research and create applicable therapies. Induced pluripotent stem cells – iPSCs – represent significant ...
- Induced pluripotent stem cell (iPSC) cytokineson December 8, 2023 at 11:22 pm
Induced pluripotent stem cells (iPSCs) are a hopeful alternative for analyzing antigen expression in vitro and developing novel cellular therapies. iPSCs have been derived from differentiated ...
- Turning Somatic Cells into Pluripotent Stem Cellson December 5, 2021 at 3:43 pm
Saha, K. & Jaenisch, R. Technical challenges in using human induced pluripotent stem cells to model disease. Cell Stem Cell 5, 584–595 (2009). Takahashi, K. & Yamanaka, S. Induction of ...
The Latest Google Headlines on:
Human induced pluripotent stem cells
[google_news title=”” keyword=”human induced pluripotent stem cells” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]