A high-tech form of brain surgery that replaces scalpels with sound waves improved quality of life for people with Parkinson’s disease that has resisted other forms of treatment, a new study has found.
Further, the School of Medicine researchers conclude their study offers “comprehensive evidence of safety” in terms of the approach’s effect on mood, behavior and cognitive ability, areas not significantly explored in previous research.
“In our initial study that looked at the outcomes of focused ultrasound surgery in Parkinson’s disease, we primarily described post-operative improvements in motor symptoms, specifically tremor,” said Scott Sperling, PsyD, a clinical neuropsychologist at UVA. “In this study, we extended these initial results and showed that focused ultrasound thalamotomy is not only safe from a cognitive and mood perspective, but that patients who underwent surgery realized significant and sustained benefits in terms of functional disability and overall quality of life.”
Focused Ultrasound and Parkinson’s Disease
Focused ultrasound, as the procedure is known, has already been approved by the federal Food and Drug Administration for the treatment of essential tremor, the most common movement disorder. That approval came after a pioneering international study led by UVA neurosurgeon Jeff Elias, MD. He and his colleagues have since demonstrated the technology’s potential in reducing tremor in people with drug-resistant Parkinson’s disease. The goal is to use focused sound waves to interrupt the faulty brain circuits responsible for the uncontrollable shaking associated with the disease.
The new study looked at the effects on 27 adults, all with severe Parkinson’s tremor that had not responded to previous treatment. The study participants were initially divided into two groups. Twenty received the procedure, while seven received a fake procedure, to serve as a control group. (The seven in the control group were later offered the opportunity to receive the real procedure, and all but one did.)
After receiving the procedure, study participants reported improved quality of life at both three months and 12 months. “After surgery, patients experienced significant improvements in multiple aspects of quality of life, including their ability to perform simple daily tasks, emotional well-being and the sense of stigma they experienced due to their tremor,” Sperling said. “Our results suggest that post-operative improvements in tremor lead to very meaningful improvements in day-to-day functioning and, subsequently, to better overall quality of life.”
The Effects on Mood and Memory in Parkinson’s
The study was notable for its in-depth examination of the psychological and cognitive effects of the procedure, areas that have received relatively little attention in previous research.
The researchers found that mood and cognition, and the ability to go about daily life, ultimately had more effect on participants’ assessment of their overall quality of life than did their tremor severity or the amount of tremor improvement seen after the procedure.
“A person’s perception of their quality of life is shaped in many different ways,” Sperling said. “Mood and behavioral symptoms, such as depression, anxiety and apathy, often have a greater impact on quality of life than the measurable severity of one’s tremor.”
The only cognitive declines seen in participants followed through the study were in how quickly they were able to name colors and think of and speak words. The cause of this was unclear, though the researchers suggested this could be a result of the natural progression of Parkinson’s. (Focused ultrasound is being tested to address the tremor associated with the disease, not its other symptoms.)
The researchers noted that their study was limited by its small size and the fact that participants’ medication dosing varied, among other factors.
To become available as a treatment for medication-resistant Parkinson’s, the approach would need approval from the FDA. UVA’s new research is an important step in that process.
Learn more: Scalpel-Free Surgery Improves Quality of Life for Parkinson’s Patients, Study Finds
The Latest on: Ultrasound surgery
[google_news title=”” keyword=”ultrasound surgery” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Ultrasound surgery
- Titan Medical gives progress report about Conavi mergeron April 27, 2024 at 5:00 am
Titan Medical and Conavi aim to commercialize Conavi’s Novasight Hybrid system for guiding common minimally invasive coronary procedures.
- Mum’s warning after son’s cancer detected through tiny unusual glow in his eyeon April 27, 2024 at 2:01 am
Mum’s warning after son’s cancer detected through tiny unusual glow in his eye - Experts say the typical signs of retinoblastoma include a white glow which may only appear in certain lights or a squin ...
- "I Wish More People Talked About It": Women Are Sharing Things They Didn’t Learn About Their Bodies Until It Happened To Themon April 26, 2024 at 8:46 pm
I recently asked the women of the BuzzFeed Community to share things they didn't learn about their bodies until it happened to them, and I received an overwhelming amount of responses. Reading through ...
- Noninvasive liver cancer treatment now offered in Seattle's First Hill: HealthLinkon April 26, 2024 at 5:20 pm
The new treatment is called "Histotripsy" and uses ultrasound waves to target tumors and eliminates the need for patients to undergo surgery.
- A haven no more: Women’s groups brace for Florida’s 6-week abortion banon April 26, 2024 at 3:00 am
Out-of-state abortions will be more expensive, difficult to get for women across much of the South, advocates warn.
- Women had breast implants removed after NHS wrongly told her they’d rupturedon April 24, 2024 at 9:14 pm
A 66 year old woman from Hampshire was forced to undergo unnecessary surgery to remove her breast implants after a hospital incorrectly told her they had ruptured. Clinicans at Hampshire Hospitals NHS ...
- Muyinatu Bell receives 2024 Alan T. Waterman Awardon April 24, 2024 at 10:19 am
Recognized for her pioneering interdisciplinary research spanning photoacoustic and ultrasound imaging, Bell is first Johns Hopkins winner in the award's 48-year history ...
- Mill Creek clinic can now cure some skin cancers without surgeryon April 18, 2024 at 6:30 am
Cayford had undergone Mohs micrographic surgery, the most common method to remove skin cancer, at Frontier Dermatology in Mill Creek. The surgery has a 99% cure rate, but can leave lifelong scarring.
- Dear Doctor: Complication rate in women much higher than for men after groin hernia surgeryon April 17, 2024 at 6:01 am
Part of the reason for the high complication rate is that many of these surgeries are done on an emergency basis.
via Bing News