Scientists at Brigham and Women’s Hospital (BWH) have developed a scalable, next-generation platelet bioreactor to generate fully functional human platelets in vitro. The work is a major biomedical advancement that will help address blood transfusion needs worldwide.
The study is published July 21, 2014 in Blood.
“The ability to generate an alternative source of functional human platelets with virtually no disease transmission represents a paradigm shift in how we collect platelets that may allow us meet the growing need for blood transfusions,” said Jonathan Thon, PhD, Division of Hematology, BWH Department of Medicine, lead study author.
According to the researchers, more than 2.17 million platelet units from donors are transfused yearly in the United States to treat patients undergoing chemotherapy, organ transplantation and surgery, as well as for those needing blood transfusions following a major trauma. However, increasing demand; a limited five-day shelf-life; and risk of contamination, rejection and infection have made blood platelet shortages common.
“Bioreactor-derived platelets theoretically have several advantages over conventional, donor-derived platelets in terms of safety and resource utilization,” said William Savage, MD, PhD, medical director, Kraft Family Blood Donor Center at Dana Farber Cancer Institute/Brigham and Women’s Hospital, who did not contribute to the study. “A major factor that has limited our ability to compare bioreactor platelets to donor platelets is the inefficiency of growing platelets, a problem that slows progress of clinical research. This study addresses that gap, while contributing to our understanding of platelet biology at the same time.”
Read more . . .
The Latest on: Platelet bioreactor
[google_news title=”” keyword=”Platelet bioreactor” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Platelet bioreactor
- Platelet Disorderson April 26, 2024 at 5:00 pm
The pathogenesis of suboptimal platelet function is multifactorial. Platelets do not function well if there are too many or too few platelets; also the platelets can be present in the appropriate ...
- Dear Doctor: Are there health risks to donating blood platelets too often?on April 25, 2024 at 11:00 pm
The American Red Cross was delighted, too! My blood type is AB negative, and I learned that it is the universal donor type for platelets. The Red Cross reached out to me by phone, text and email ...
- Corn cobs can recharge bioreactorson April 10, 2024 at 5:00 pm
Corn cobs may perform better than woodchips to reduce nitrates in water quality bioreactors -- and for a lesser cost -- state Iowa State University researchers. The challenge is getting an ...
- Impact of lipid emulsions in parenteral nutrition on platelets: a literature reviewon March 24, 2024 at 5:00 pm
The complexity of the formulations of lipid emulsions may lead to adverse outcomes such as platelet reactivity and changes in platelet aggregation and related coagulation. Platelets are responsible ...
- How to Increase Yields & Throughputs in mRNA Productionon September 19, 2023 at 10:08 am
Cold chain management is a crucial part of the mRNA production and distribution process.Temperature also plays a vital role in the laboratory production of mRNA, specifically within the enzymatic ...
- Efficacy of platelet-rich plasma injections in osteoarthritis of the knee: a systematic review and meta-analysison February 23, 2023 at 5:11 am
Background The effectiveness of platelet-rich plasma (PRP) injections for osteoarthritis (OA) is still controversial. We investigated the effect of PRP injections in patients with knee OA based on ...
- Is Platelet-Rich Plasma (PRP) a Safe and Effective Treatment for Osteoarthritis of the Knee?on May 10, 2020 at 5:00 pm
Platelet-rich plasma (PRP) therapy is a treatment that uses your own blood to treat damaged tissues. It may help reduce pain from osteoarthritis, but more research is needed. Injections of ...
- Developing Life-Saving Artificial Plateletson June 1, 2019 at 4:21 pm
But the fundamental goals are the same: to develop artificial platelets that can speed up and expand the formation of clots to both reduce internal bleeding and address bleeding disorders. They also ...
- The secret life of plateletson April 12, 2018 at 5:00 pm
Are platelets involved in immunity and disease progression? There may be more to these cellular fragments than meets the eye. Platelets flow abundantly in the blood and are best known for their ...
- 2mag bioREACTOR 48 for High-Throughput Bioprocess Developmenton April 18, 2016 at 10:57 am
The 2mag bioREACTOR 48 is a new developed, space-saving and user-friendly bioreaction block with up to 48 parallelized mini reactors. The high parallelization allows an easy realization of high ...
via Bing News