A chip placed under the skin for more precise medicine

The future of medicine lies in ever greater precision, not only when it comes to diagnosis but also drug dosage.

The blood work that medical staff rely on is generally a snapshot indicative of the moment the blood is drawn before it undergoes hours – or even days – of analysis.

Several EPFL laboratories are working on devices allowing constant analysis over as long a period as possible. The latest development is the biosensor chip, created by researchers in the Integrated Systems Laboratory working together with the Radio Frequency Integrated Circuit Group. Sandro Carrara is unveiling it today at the International Symposium on Circuits and Systems (ISCAS) in Lisbon.

Autonomous operation

“This is the world’s first chip capable of measuring not just pH and temperature, but also metabolism-related molecules like glucose, lactate and cholesterol, as well as drugs,” said Dr Carrara. A group of electrochemical sensors works with or without enzymes, which means the device can react to a wide range of compounds, and it can do so for several days or even weeks.

This one-centimetre square device contains three main components: a circuit with six sensors, a control unit that analyses incoming signals, and a radio transmission module. It also has an induction coil that draws power from an external battery attached to the skin by a patch. “A simple plaster holds together the battery, the coil and a Bluetooth module used to send the results immediately to a mobile phone,” said Dr Carrara.

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The Latest on: Biosensor chip

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