Bioprinting: From concept to reality
The human cell represents the smallest functional unit of life. All tissues in the body are composed of multiple cell types, typically arranged in a 3-D architecture that is relevant to the functions they carry out. Since cells were first isolated and grown in the laboratory environment, biologists and engineers have pursued the utilization of these tiny building blocks in the reconstruction and regeneration of functional tissue. Whether used in a controlled laboratory setting to model specific diseases and test the effects of drugs, or delivered into the body as therapeutics for the treatment of disease, the common goal is to establish or re-establish in vivo-like function.
The field of tissue engineering has deployed several fabrication strategies aimed at bringing cells and structure together to generate tissue. Biomaterial scaffolding—which provides structural support and can be formed into biologically relevant shapes—has been combined with cells to generate hybrid 3-D structures for use as tissue surrogates in vitro and in vivo. Protocols have been developed that enable removal of living cells from native tissues, leaving only a natural scaffolding of extracellular matrix, which can then be re-seeded with cells to reconstruct or partially reconstruct 3-D tissues. Another approach to soft tissue reconstruction has been the development of cell-laden hydrogels, which are often cast into a specific shape and placed into a permissive environment in vitro or in vivo that allows maturation and establishment of tissue-specific characteristics. In recent years, with the advancement of 3-D printing technologies for the on-demand fabrication of complex polymer-based objects, efforts have been underway to adapt 3-D printing technologies and engineer bioprinting instruments that can leverage similar 3-D replication concepts and accommodate the incorporation of living cells.
First-generation 3-D prototyping techniques relied on subtractive processes—the removal of material from a solid block using filing, milling, drilling, cutting and grinding methods. Advanced 3-D prototyping technologies utilize additive processes in which the desired part is built up—or “printed” layer-by-layer. Objects of virtually any shape can now be fabricated from a wide range of non-biological materials using additive technologies.
The power and utility of 3-D printing in the non-biological materials area has sparked the imaginations of biologists and engineers alike and fueled R&D activities aimed at producing intricate biological 3-D structures. Consequently, precise, automated, layer-by-layer fabrication of tissue (bioprinting) is now possible using only living cells as building blocks. This is resulting in simultaneous achievement of unique features such as true 3-D, tissue-like cellular densities and reproduction of native tissue architecture through the spatially directed placement of distinct cell types.
Bioprinting hardware requires unique features that ensure success at the interface of engineering and biology.
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Bioprinting
- New technique bioprints live cells inside the body using ultrasonic waveson May 8, 2024 at 10:36 pm
Revolutionary acousto-printing method can be used to circumvent invasive surgery, and has a wide array of potential applications.
- 3D Bioprinting Market Expected to Hit USD 6.9 Billion by 2032 | Market.Uson April 11, 2024 at 11:10 pm
According to a recent report by Market.us, the Global 3D Bioprinting Market size is expected to be worth around USD 6.9 Billion by 2032 from USD 1.9 Billion in 2023, growing at a CAGR of 16.1% during ...
- 3D printing and bioprinting in healthcare - statistics and factson April 10, 2024 at 5:00 pm
Bioprinting is a much newer technology compared to 3D printing and uses bioinks and other biomaterials to create organ-like structures. Some have referred to bioprinting as ‘healthcare’s next ...
- Advancing gastric cancer treatment through personalized 3D bioprintingon March 21, 2024 at 10:37 am
By using 3D bioprinting to accurately replicate the biological environment surrounding gastric cancer cells, the researchers have achieved a significant feat—predicting a patient's response to ...
- Bioprinting News and Researchon March 17, 2024 at 5:00 pm
FluidForm Bio, a leader in developing life-like human tissue to treat disease, shares recent advancements in building human cardiac tissues using FRESH™ 3D bioprinting. FluidForm Bio ...
- TissueFab® bioink Conductive for 3D bioprintingon November 22, 2023 at 11:00 pm
TissueFab ® bioink Conductive Vis/405 nm, low endotoxin, is a bioink tailored for 3D bioprinting with electrical conductivity. This specialized bioink is designed to create optimal conditions for ...
- Revolutionising osteoarthritis treatment through bioprintingon September 25, 2023 at 7:40 am
In collaboration with clinicians and cell biologists and using the unique capability of The University of Manchester’s Bioprinting Platform, Dr Marco Domingos is developing new technology-driven ...
- 26 Million New Cases, Three Dimensions, And One New Technology: How Bioprinting Can Improve Cancer Treatmentson July 11, 2023 at 3:30 pm
printed from a model (such as the gold bracelet model seen on the laptop screen). Bioprinting, also known as 3D bioprinting, uses cells, growth factors (naturally occurring substances that help ...
- Will 'Bioprinting' Body Parts Lead To Crazy Cosmetic Requests?on July 19, 2022 at 5:00 pm
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- How bioprinting workson May 8, 2011 at 5:00 pm
The first bioprinters were jury-rigged desktop inkjet printers. Now, some labs use machines, made specifically for bioprinting, that cost up to $300,000. Cornell labs make multipurpose 3-D ...
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The Latest Bing News on:
Tissue engineering
- New technique bioprints live cells inside the body using ultrasonic waveson May 8, 2024 at 10:36 pm
Revolutionary acousto-printing method can be used to circumvent invasive surgery, and has a wide array of potential applications.
- Fresh hope for chronic woundson May 8, 2024 at 7:44 am
New approaches in drug delivery for brain cancer At UD, Pochan continues to explore new uses for the UD-developed biomaterials, from immunotherapy to tissue engineering. In one project, his research ...
- Tissue Engineering of Vascular Prosthetic Graftson May 7, 2024 at 10:43 pm
The book Tissue Engineering of Vascular Prosthetic Grafts, edited by Peter Zilla and Howard Greisler, explores the basic biology, clinical background and pathology of synthetic vascular graft ...
- Green Biomaterials for Tissue Engineering and Nanomedicine Applications: Recent Advances and Future Trendson May 7, 2024 at 7:22 am
The global ecological burden that includes the progressive fossil resources depletion and the simultaneous global population growth and waste production intensification, requires adequate efforts for ...
- Tissue Engineering Market Competition: Assessing Key Challenges and Opportunitieson May 5, 2024 at 4:28 pm
The global tissue engineering market size was US$ 12.1 billion in 2021. The global tissue engineering market is forecast to grow to US$ 39.4 billion by 2030 by registering a compound annual growth ...
- Novel fabrication method creates aligned nanofiber hydrogels for tissue regenerationon May 3, 2024 at 10:12 pm
A team of chemists and bioengineers at Rice University and the University of Houston have achieved a significant milestone in their work to create a biomaterial that can be used to grow biological ...
- New experimental evidence unlocks a puzzle in vascular tissue engineeringon April 25, 2024 at 9:25 am
Angiogenesis is a process of forming hierarchical vascular networks in living tissues. Its complexity makes the controlled generation of blood vessels in laboratory conditions a highly challenging ...
- Tissue Engineering and Regeneration Market [2028]: Navigating Opportunities and Challengeson April 24, 2024 at 3:11 am
USD 14.57 billion in 2022 and is poised for substantial growth, projecting a Compound Annual Growth Rate (CAGR) of 8.35% through 2028.
- Tissue Engineering News and Researchon April 23, 2024 at 5:00 pm
The field of bone tissue engineering (BTE) was a promising avenue for addressing bone injuries and defects by constructing artificial scaffolds with bionic functionalities. The promising results ...
- Optimizing tissue engineering in rotator cuff repairon March 18, 2024 at 10:00 am
Advances in tissue engineering have demonstrated that mesenchymal stem cells (MSCs) and growth factors (GFs) enhance the regeneration of rotator cuff tendon-to-bone insertion in animal models ...
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