via Quadram Institute
In the search for eternal youth, poo transplants may seem like an unlikely way to reverse the ageing process.
However, scientists at the Quadram Institute and the University of East Anglia have provided evidence, from research in mice, that transplanting faecal microbiota from young into old mice can reverse hallmarks of ageing in the gut, eyes, and brain.
In the reverse experiment, microbes from aged mice induced inflammation in the brain of young recipients and depleted a key protein required for normal vision.
These findings show that gut microbes play a role in the regulating some of the detrimental effects of ageing and open up the possibility of gut microbe-based therapies to combat decline in later life.
Prof Simon Carding, from UEA’s Norwich Medical School and head of the Gut Microbes and Health Research Programme at the Quadram Institute, said: “This ground-breaking study provides tantalising evidence for the direct involvement of gut microbes in ageing and the functional decline of brain function and vision and offers a potential solution in the form of gut microbe replacement therapy.”
It has been known for some time that the population of microbes that we carry around in our gut, collectively called the gut microbiota, is linked to health. Most diseases are associated with changes in the types and behaviour of bacteria, viruses, fungi and other microbes in an individual’s gut.
Some of these changes in microbiota composition happen as we age, adversely affecting metabolism and immunity, and this has been associated with age-related disorders including inflammatory bowel diseases, along with cardiovascular, autoimmune, metabolic and neurodegenerative disorders.
To better understand the effects of these changes in the microbiota in old age, scientists from the Quadram Institute transferred the gut microbes from aged mice into healthy young mice, and vice versa. They then looked at how this affected inflammatory hallmarks of ageing in the gut, brain and eye, which suffer from declining function in later life.
The study, published in the journal Microbiome, found that the microbiota from old donors led to loss of integrity of the lining of the gut, allowing bacterial products to cross into the circulation, which results in triggering the immune system and inflammation in the brain and eyes.
Age-related chronic inflammation, known as inflammageing, has been associated with the activation of specific immune cells found in brain. These cells were also over-activated in the young mice who received aged microbiome transplants.
In the eye, the team also found specific proteins associated with retinal degeneration were elevated in the young mice receiving microbiota from old donors.
In old mice, these detrimental changes in the gut, eye and brain could be reversed by transplanting the gut microbiota from young mice.
In ongoing studies, the team are now working to understand how long these positive effects can last, and to identify the beneficial components of the young donor microbiota and how they impact on organs distant from the gut.
The microbiota of young mice, and the old mice who received young microbiota transplants were enriched in beneficial bacteria that have previously been associated with good health in both mice and humans.
The researchers have also analysed the products which these bacteria produce by breaking down elements of our diet.
This has uncovered significant shifts in particular lipids (fats) and vitamin metabolism, which may be linked to the changes seen in inflammatory cells in the eye and brain.
Similar pathways exist in humans, and the human gut microbiota also changes significantly in later life, but the researchers caution about extrapolating their results directly to humans until similar studies in elderly humans can be performed.
A new facility for Microbiota Replacement Therapy (MRT), also known as Faecal Microbiota Transplantation (FMT) is being built in the Quadram Institute that will facilitate such trials, as well as other trials for microbiota-related conditions.
Lead author of the study, Dr Aimee Parker from the Quadram Institute said: “We were excited to find that by changing the gut microbiota of elderly individuals, we could rescue indicators of age-associated decline commonly seen in degenerative conditions of the eye and brain.
“Our results provide more evidence of the important links between microbes in the gut and healthy ageing of tissues and organs around the body. We hope that our findings will contribute ultimately to understanding how we can manipulate our diet and our gut bacteria to maximise good health in later life.”
Original Article: FAECAL TRANSPLANTS REVERSE HALLMARKS OF AGEING
More from: University of East Anglia | Quadram Institute
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
Microbiota Replacement Therapy
- Ketogenic diet a potential therapy for autism by reshaping gut bacteria and brain inflammation
Modified ketogenic diet modulates gut microbiome, inflammatory markers, and brain-related miRNAs in autistic children, correlating with improved behavioral symptoms. The diet increases beneficial gut ...
- Microbiota Therapeutics Could Become Strong Ally in IBD Treatment
Microbiota therapeutics, such as fecal microbiota transplantation ... In addition, clinical trials need to define whether microbial modulation should be used as separate or adjunctive therapy, Sartor ...
- Hormone therapy for menopause is safer than previously thought, study finds
Massive women's health study finds most women under 60 will get some relief from menopause symptoms but it won't reduce heart risks ...
- Is Natural Hormone Replacement Therapy Better?
Natural hormone replacement therapy (NHRT) is considered an alternative approach to conventional hormone replacement therapy (HRT). It may use natural or " bioidentical " treatments to restore ...
- Listen to your gut: Using microbiota analysis for precision health care
In a recently published paper, Pak Kin Wong discusses the methods discusses the methods available for incorporating microbiota analysis ... have emerged as a pivotal therapy for refractory C.
Go deeper with Google Headlines on:
Microbiota Replacement Therapy
[google_news title=”” keyword=”Microbiota Replacement Therapy” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]
Go deeper with Bing News on:
Inflammageing
- Aims & Scope
inflammaging, cardiovascular diseases and neurological disorders; and medical and health research specifically focusing on older people, such as studies in geriatrics and gerontology. Our ...
- This Meno-Belly Diet Heals the Hidden Nerve Glitch That Makes It Hard to Lose Weight After Age 50
Setting ourselves up for successful weight loss after menopause can be a challenge. Not only are we fatigued and battling hot flashes, it also sometimes seems like our bellies grew bigger overnight.
- Hacking the immune system could slow ageing — here’s how
Yet all she had done was to briefly treat them — many weeks earlier — with a drug that corrected the organization of proteins inside a type of stem cell. When technicians who were replicating her ...
- Bone and Spine News
Dec. 6, 2023 — Aging is associated with chronic, nonresolving inflammation, or 'inflammaging,' that can lead to tissue dysfunction. New findings reveal insights into the cellular programs and ...
- Nutritionist-turned-celeb spa owner shares dietary tips for an A-list glow
Marius Morariu, a holistic nutritionist and the co-founder of Manhattan’s celebrity-loved Tracie Martyn, a spa known for prepping stars for the Met Gala and the Oscars with their signature facials and ...
Go deeper with Google Headlines on:
Inflammageing
[google_news title=”” keyword=”inflammageing” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]