via Indiana University School of Medicine
A silicone device that can change skin tissue into blood vessels and nerve cells has advanced from prototype to standardized fabrication, meaning it can now be made in a consistent, reproducible way. As reported in Nature Protocols, this work, developed by researchers at the Indiana University School of Medicine, takes the device one step closer to potential use as a treatment for people with a variety of health concerns.
The technology, called tissue nanotransfection, is a non-invasive nanochip device that can reprogram tissue function by applying a harmless electric spark to deliver specific genes in a fraction of a second. In laboratory studies, the device successfully converted skin tissue into blood vessels to repair a badly injured leg. The technology is currently being used to reprogram tissue for different kinds of therapies, such as repairing brain damage caused by stroke or preventing and reversing nerve damage caused by diabetes.
“This report on how to exactly produce these tissue nanotransfection chips will enable other researchers to participate in this new development in regenerative medicine,” said Chandan Sen, director of the Indiana Center for Regenerative Medicine and Engineering, associate vice president for research and Distinguished Professor at the IU School of Medicine.
Sen also leads the regenerative medicine and engineering scientific pillar of the IU Precision Health Initiative and is lead author on the new publication.
“This small silicone chip enables nanotechnology that can change the function of living body parts,” he said. “For example, if someone’s blood vessels were damaged because of a traffic accident and they need blood supply, we can’t rely on the pre-existing blood vessel anymore because that is crushed, but we can convert the skin tissue into blood vessels and rescue the limb at risk.”
In the Nature Protocols report, researchers published engineering details about how the chip is manufactured.
Sen said this manufacturing information will lead to further development of the chip in hopes that it will someday be used clinically in many settings around the world.
“This is about the engineering and manufacturing of the chip,” he said. “The chip’s nanofabrication process typically takes five to six days and, with the help of this report, can be achieved by anyone skilled in the art.”
Sen said he hopes to seek FDA approval for the chip within a year. Once it receives FDA approval, the device could be used for clinical research in people, including patients in hospitals, health centers and emergency rooms, as well as in other emergency situations by first responders or the military.
Original Article: Innovative silicone nanochip can reprogram biological tissue in living body
More from: Indiana University School of Medicine | University of Chicago
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
Tissue nanotransfection
- Craft Vibrant Roses From Tissue
Beijing Warns US After Missile Launcher Reaches 'China's Doorstep' The Only Way You Should Store Cream Cheese, According to Philadelphia Roku TVs just got a big free ...
- Will Heart Valve Tissue Engineering Change the World?
Nat Clin Pract Cardiovasc Med. 2005;2(2):60-61. Several strategies for heart valve tissue engineering are evolving. They include the use of decellularized allogenic or xenogenic valve matrices ...
- Presence of specific lipids indicate tissue aging and can be decreased through exercise, study shows
Scientists have discovered that a type of fat accumulates as tissue ages and that this accumulation can be reversed through exercise. Researchers from Amsterdam UMC, together with colleagues from ...
- Tissue Nanotransfection Market To Reach USD 9.8 Billion By 2032 | DataHorizzon Research
The tissue nanotransfection (TNT) market stands to expand significantly through partnerships and alliances among government agencies, businesses, and academia. By leveraging resources and ...
- Muscle tissue harvested from mice cells move ‘biohybrid’ robots
The team is going beyond simply mimicking muscles here, however. Researchers at the school are using live muscle tissue in tandem with synthetic robot parts for a classification of robots known as ...
Go deeper with Google Headlines on:
Tissue nanotransfection
[google_news title=”” keyword=”tissue nanotransfection” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]
Go deeper with Bing News on:
Tissue reprogramming
- Researchers develop new AI tool for fast and precise tissue analysis to support drug discovery and diagnostics
A team of scientists has developed a new AI software tool called 'BANKSY' that automatically recognizes the cell types present in a tissue, such as muscle cells, nerve cells and fat cells. Going a ...
- ‘Engineering’ OA Treatment Lands $31M Research Award
The Advanced Research Projects Agency for Health (ARPA-H) has awarded up to $31 million to researchers at Washington University in St. Louis to support the development of non-surgical osteoarthritis ...
- Unlocking Longevity: New Study Reveals Brain-Muscle Clock Synchronization Prevents Aging
A recent study in mice has revealed that molecular circadian clocks in the brain and muscle tissue work together to maintain muscle health and daily function. This research could offer crucial insight ...
- Expanding a lymph node, boosting a vaccine
For the first time, researchers from the Wyss Institute for Biologically Inspired Engineering at Harvard University, Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), ...
- Fetal Organoids Generated From Human Amniotic Fluid
7 However, reprogramming methods take up to 20 weeks to generate organoids ... following the procedure, indicating tissue maturation. However, due to a limited sample size, they did not perform within ...
Go deeper with Google Headlines on:
Tissue reprogramming
[google_news title=”” keyword=”tissue reprogramming” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]