via OHSU
An innovative new technique that encourages cancer cells in the kidneys to self-destruct could revolutionise the treatment of the disease, a new study in the journal Pharmaceutics reports.
During this unique study, researchers from the University of Surrey and Sechenov First Moscow State Medical University in Russia investigated whether certain naturally occurring proteins within the body can be used to treat cancer.
Focusing on cathepsin S, a member of the lysosomal cathepsin proteins that are known to affect cancer progression, and p21 BAX, a protein that can stimulate cell destruction, researchers found that both can be deployed simultaneously to fight cancer cells in a two-pronged ‘attack.’ They act firstly by stopping the mechanism that makes certain treatments of the disease ineffective, and secondly by effectively encouraging cancerous cells to self-destruct.
This revolutionary approach targets two converging regulatory pathways that can sometimes be resistant to chemotherapy and has led to the development of a potential ground-breaking therapy using a novel peptide, CS-PEP1. Researchers found that this peptide inhibits both cathepsin S and its ability to break down the p21 BAX protein, resulting in the accumulation of p21 BAX, which encourages the death of cancer cells in the kidneys. The twin-track effect of this peptide can also override the molecular resistance often found during conventional chemotherapy treatment and offers a novel and effective approach in treating cancer.
An increased focus on therapeutic cancer treatments has signalled a move away from traditional methods such as chemotherapy and radiotherapy, as therapeutic treatments have been found to cause less harm to normal cells and fewer side effects for patients.
Professor Paul Townsend, Principal Investigator, Pro-Vice-Chancellor, and Executive Dean of the Faculty of Health and Medical Sciences at the University of Surrey, said: “Kidney cancer is a very difficult type of cancer to cure; there is an increased need to think innovatively to develop new techniques. We have now discovered that proteins already in the body can be manipulated to encourage cancerous cells to die. This is an extraordinary breakthrough and insight, and can be used to potentially inform the treatment of other types of aggressive cancers, such as cancers of the breast and prostate.”
Original Article: Innovative technique developed to destroy cancerous kidney cells
More from: University of Surrey | First Moscow State Medical University
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
Encouraging cancerous cells to self-destruct
- Pan-cancer analysis uncovers a new class of promising CAR T--cell immunotherapy targets
St. Jude found 156 potential targets for chimeric antigen receptor (CAR) T--cell immunotherapy. Explore the discovery's promise to improve cancer therapies.
- Use of Allogeneic NK Cells for Cancer Immunotherapy
Controversy exists as to the role that the immune system plays in cancer ... cells were directed against tumors but it was realized that NK cells that recognize self cells are inhibited. More ...
- Cavs self-destruct in the second half, watch helplessly as Orlando Magic even series with 112-89 win
And then they self-destructed. Cleveland lost Game 4 to the Orlando Magic on Saturday afternoon, 112-89. The once-lopsided matchup, with the Cavs in total control, is now tied at two games apiece.
- I Was Told I Had an STI. It Was Actually Cervical Cancer
routine tests for the virus (the vaccine doesn’t protect against every single type), and regular Pap smears (to screen for precancerous cells). Here’s her story, as told to SELF’s associate ...
- Cancer Cells Give Orders
View full profile. Learn about our editorial policies. “[It is] interesting work that further highlights the complex intercellular crosstalk between stromal cells in cancer,” said Giulia Biffi, a ...
Go deeper with Google Headlines on:
Encouraging cancerous cells to self-destruct
[google_news title=”” keyword=”encouraging cancerous cells to self-destruct” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]
Go deeper with Bing News on:
Kidney cancer
- Identifying Good Candidates for Active Surveillance of Kidney Cancer
Patients with small or slow-growing tumors or those with comorbidities that make them higher risk are likely better candidates for active surveillance, explained Yuzhi Wang, MD, of Henry Ford Health ...
- Immunotherapy: A Beacon of Hope in Cancer Treatment
Cancer, a disease that has plagued humanity for centuries, has finally met its match in immunotherapy, a revolutionary treatment that harnesses the power of the immune system to combat this deadly ...
- AFFF MDL Bellwether Process Extended to Claims for Thyroid and Liver Cancer Caused by PFAS
The personal injury bellwether processes in the AFFF MDL now encompass claims for kidney cancer, testicular cancer, hypothyroidism/thyroid disease, ulcerative colitis, thyroid cancer and liver cancer.
- Mystery risk factor linked to high rates of kidney cancer, major DNA study finds
The cancers contained more of the mutations in countries with a higher incidence of kidney cancer. The researchers suggest the mutation – labelled SBS40b by the team – could be caused by a mystery ...
- Bedford Fire Department launches fundraising effort to support one of their own diagnosed with cancer
BEDFORD COUNTY, Va. (WDBJ) - In Bedford County, the local fire department is rallying around one of their own. It’s Deputy Fire Chief Matt Scott’s job to save others but his fellow firefighters, ...
Go deeper with Google Headlines on:
Kidney cancer
[google_news title=”” keyword=”Kidney cancer” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]