Super resolution microscopy is a technique that can see beyond the diffraction of light and provides unprecedented views of cells and their interior structures and organelles.
An EPFL team has developed a technique that can perform both 3D super resolution microscopy and fast 3D phase imaging in a single instrument.
This unique 4D microscope combines a sensitivity and high time resolution of phase imaging with the specifically and high spatial resolution of fluorescence microscopy. This allows the direct visualization and Analysis of subcellular structures in living cells without labeling.
These technical advances enable high-resolution visualization of the formation of pathological alpha-synuclein aggregates in hippocampal neurons. It is hoped that it will become a regular workhorse for neuroscience and biology.
Learn more: Super-resolution microscopy in both space and time
The Latest on: Super resolution microscopy
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The Latest on: Super resolution microscopy
- Imaging Technique Shows New Details of Alzheimer’s Peptide Structureson April 29, 2024 at 1:38 am
A new imaging technique developed by engineers at Washington University in St. Louis can give scientists a much closer look at fibril assemblies — stacks of peptides that include amyloid beta, most ...
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C-terminal fragments of amyloid precursor protein have been blamed for endolysosomal dysfunction in Alzheimer’s disease. Now, scientists led by Wim Annaert at KU Leuven, Belgium, claim that’s because ...
- New imaging technique provides a much closer look at fibril assemblieson April 26, 2024 at 10:47 pm
A new imaging technique developed by engineers at Washington University in St. Louis can give scientists a much closer look at fibril assemblies, stacks of peptides like amyloid beta, most notably ...
- A Novel Cellular Mechanism Used to Repair DNA Damage is Revealedon April 25, 2024 at 7:05 pm
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- Testing how well biomarkers work: New fluorescence microscopy method can improve resolution down to the Ångström scaleon April 24, 2024 at 9:49 am
LMU researchers have developed a method to determine how reliably target proteins can be labeled using super-resolution fluorescence microscopy.
- 30 Times Clearer – Scientists Develop Improved Mid-Infrared Microscopeon April 24, 2024 at 3:55 am
The chemical images taken of the insides of bacteria were 30 times clearer than those from conventional mid-infrared microscopes. Researchers at the University of Tokyo have developed an advanced ...
- Testing how well biomarkers workon April 23, 2024 at 5:00 pm
The authors of the study are certain that the new quantification method has paved the way for significantly expanding the potential of their super-resolution microscope method: “Now we can also ...
- Biophysics: Testing how well biomarkers workon April 23, 2024 at 5:00 pm
Researchers have developed a method to determine how reliably target proteins can be labeled using super-resolution fluorescence microscopy. LMU researchers have developed a method to determine how ...
- Advancing high-resolution ultrasound imaging with deep learningon April 22, 2024 at 11:38 am
Researchers at the Beckman Institute for Advanced Science and Technology have developed a new technique to make ultrasound localization microscopy, an emerging diagnostic tool used for high-resolution ...
- New super-resolution microscopy approach visualizes internal cell structures and clusters via selective plane activationon April 22, 2024 at 9:08 am
To study living organisms at ever smaller length scales, scientists must devise new techniques to overcome the so-called diffraction limit. This is the intrinsic limitation on a microscope's ability ...
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