Scientists at the University of Basel have shown that LSD reduces activity in the region of the brain related to the handling of negative emotions like fear. The results, published in the scientific journal Translational Psychiatry, could affect the treatment of mental illnesses such as depression or anxiety.
Hallucinogens have many different effects on the psyche; among other things, they alter perception, thought, and temporal and emotional experience. After the Basel-based chemist Albert Hofmann discovered lysergic acid diethylamide (LSD) in the 1940s, there was a huge amount of interest in the substance, particularly in psychiatry. It was hoped, for example, that it could provide insights into the development of hallucinations, and studies were conducted on its effectiveness on illnesses such as depression or alcohol dependency. In the 1960s, LSD was declared illegal worldwide, and medical research on it came to a standstill.
In the last few years, however, interest in researching hallucinogens for medical purposes has been revived. Psychoactive substances such as LSD, particularly in combination with psychotherapies, could offer an alternative to conventional medication. It is now known that hallucinogens bind to a receptor of the neurotransmitter serotonin; how the changes of consciousness influence the activity and connectivity of the brain, however, is not yet known.
LSD alters brain activity
Researchers at the University Psychiatric Clinics (UPK) and the Department of Pharmacology and Toxicology at the University Hospital Basel (USB) have now conducted a study into the acute effect of LSD on the brain. They used functional magnetic resonance imaging (fMRI) to measure the brain activity of 20 healthy people after taking 100 micrograms of LSD. During the MRI scan, the participants were shown images of faces portraying different emotional states such as anger, joy or fear.
Professor Stefan Borgwardt and his team showed that the depiction of fear under LSD led to a notably lower level of activity in the amygdala – an area of the brain that is believed to be central to the processing of emotions. This observation could explain some of the changes in emotional experience that occur after taking hallucinogens.
Less fear after taking LSD
In a second step, the researchers, together with clinical pharmacologists at the University Hospital Basel, examined whether the subjective experience altered by LSD is associated with the amygdala. This appears to be the case: the lower the LSD-induced amygdala activity of a subject, the higher the subjective effect of the drug. “This ‘de-frightening’ effect could be an important factor for positive therapeutic effects,” explains Doctor Felix Müller, lead author of the study. The researchers presume that hallucinogens may cause many more changes in brain activity. Further studies will investigate this, with a particular focus on their therapeutic potential.
Learn more: Less Fear: how LSD Affects the Brain
[osd_subscribe categories=’LSD’ placeholder=’Email Address’ button_text=’Subscribe Now for any new posts on the topic “LSD’]
The Latest on: LSD
[google_news title=”” keyword=”LSD” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: LSD
- Psychedelics Activate Serotonin to Produce Antidepressant Effecton May 8, 2024 at 11:51 am
A new study advanced our understanding of how psychedelic drugs activate serotonin receptors to offer potential treatments for neuropsychiatric disorders.
- ‘120 LSD strips in your parcel caught by Customs’: Senior citizen loses Rs 2 cr in cyber fraudon May 8, 2024 at 10:17 am
The senior citizen was coerced into transferring Rs 2 crore of her life savings through cyber extortion in 'drugs in parcel fraud.' ...
- Scientists unravel how psychedelic drugs interact with serotonin receptors to potentially produce therapeutic benefitson May 8, 2024 at 8:28 am
Researchers at the Icahn School of Medicine at Mount Sinai have shed valuable light on the complex mechanisms by which a class of psychedelic drugs binds to and activates serotonin receptors to ...
- Psychedelic toxins from toads could treat depression and anxietyon May 8, 2024 at 8:00 am
Similar effects have been seen in people receiving LSD or psilocybin treatments. “Frankly, that’s what we hope to see,” says Audrey Warren at Mount Sinai Hospital. Because humans share similar ...
- River festival postponed by organiserson May 8, 2024 at 5:09 am
The organisers of River Festival 2024 said this year's event was unable to go ahead due to unforeseeable operational and timing constraints. The event, organised by LSD Promotions, was due to take ...
- One Dose of LSD-Based Medication Yields Rapid, Durable Response for GADon May 7, 2024 at 10:52 am
A single oral administration of an LSD-based medicine provided rapid and durable improvement in moderate to severe generalized anxiety disorder (GAD) in a phase 2B study.
- Single Dose of LSD-Containing Drug Improved Anxiety Symptomson May 6, 2024 at 12:06 pm
A single dose of an LSD-containing investigational drug rapidly alleviated symptoms of moderate-to-severe generalized anxiety disorder (GAD), a phase IIb randomiz ...
- LSD — Yes, LSD — Shows Promising Results For Treating Anxietyon May 6, 2024 at 3:30 am
A new study shows that LSD is highly effective at treating generalized anxiety disorder for up to 12 weeks with just a single dose. And it is fast-acting.
- A champion of psychedelics who includes a dose of skepticismon May 4, 2024 at 3:00 am
Ernesto Londoño’s memoir 'Trippy' explores psychiatry's renewed flirtation with drugs such as LSD. He's a believer but not a zealot.
via Bing News