One of the most basic yet important surgical skills to keep a patient alive and intact may be closing wounds.
It seems that doctors will now get the job done with more ease thanks to new, nontoxic surgical glue that instantly seals a bleeding wound and helps it heal without a scar or inflammation.
Inspired by nature’s wonders, Korean scientists at Pohang University of Science and Technology (POSTECH) have developed a light-activated, mussel protein-based bioadhesive (LAMBA) that works on the same principles as mussels attaching to underwater surfaces and insects maintaining structural balance and flexibility. The product, called LAMBA, has emerged as a promising candidate for an ideal bioadhesive for its outstanding properties; LAMBA’s compatibility with the human body, strong adhesiveness in wet conditions, and convenient handling point to the possibility of myriad medical applications.
Mechanical fasteners like sutures and staples have accounted until recently for a major portion of conventional medical devices that are used to hold body tissues together. The invasive nature of traditional methods, however, has been the biggest drawback causing severe tissue damage, complicated post-treatment management, and scars. Their use is also limited when handling delicate tissues and internal organs, giving rise to a need for alternatives that do not require penetration. Tissue adhesives have been increasingly pursued these days as a more desirable bonding material, but the adhesives currently available in the market likewise have their own limitations. While chemically derived adhesives such as cyanoacrylates are likely to provoke an adverse reaction, biologically derived ones are not strong enough to close wounds like sutures do. A common and critical challenge, moreover, is that most surgical glues do not stick in a wet environment, which is essential for medical applications.
Dr. Hyung Joon Cha, a professor of the Department of Chemical Engineering at POSTECH, and his student, Eun Young Jeon, have developed a new approach that readily overcomes these drawbacks. The new product LAMBA, a focus of their recent publication in Biomaterials, is an upgrade version of previously known mussel-inspired adhesives that copy mussels’ ability to fix their body under water. Instead of producing recombinant mussel adhesive proteins (MAPs) by modifying DOPA, a key element for the adhesive property, E.Y. Jeon et al., have created the new tissue adhesive via a photochemical reaction using blue visible light.
“LAMBA opens numerous doors for medical practices ranging from blocking air leaks and sutureless wound closures of delicate organs or tissues beyond surgeons’ reach, to hemostatic agent and drug delivery medium, just to name a few,” commented Dr. Cha, a corresponding author of this study.
Read more:Â New mussel-inspired surgical protein glue: Close wounds, open medical possibilities
The Latest on: Bioadhesive hydrogel
[google_news title=”” keyword=”bioadhesive hydrogel” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Bioadhesive hydrogel
- Soft Hydrogel Bioadhesive for Non-Invasive Sensor Attachmenton May 7, 2024 at 3:47 pm
Researchers have developed a soft hydrogel-based bioadhesive interface to attach sensors to soft and fragile marine animals without causing harm. Published in Nature Communications, the study ...
- Gels and hydrogels articles from across Nature Portfolioon May 6, 2024 at 4:59 pm
They are usually soft and weak, but can be made hard and tough. Hydrogels are gels that have water as their main constituent. Certain devices require rapid adhesion and detachment, but achieving ...
- Best Gel Mattress for 2024on May 1, 2024 at 3:31 pm
If you’re a hot sleeper and you’re looking for a new mattress with pressure relief and motion isolation, consider switching to a gel memory foam mattress. This is a popular choice in ...
- Soft n' supple adhesive gel makes for gentler tracking of squidson April 16, 2024 at 5:01 pm
It's known as the Bioadhesive Interface for Marine Sensors ... The interface takes the form of a thin layer of dehydrated biodegradable hydrogel, which is applied to the underside of the tracker.
- 9 best gel nail kits for salon-quality manicures at homeon April 16, 2024 at 9:08 am
DIY manicures are having a resurgence, with regular polish, press-on nails and gel manicures all picking up in popularity. After all, our monthly budgets are getting smaller, our lives busier ...
- New tagging method provides bioadhesive interface for marine sensors on diverse, soft and fragile specieson April 16, 2024 at 8:51 am
Now, a newly developed soft hydrogel-based Bioadhesive Interface for Marine Sensors, referred to as BIMS, holds promise as an effective, rapid, versatile, and non-invasive method to tag and track ...
- New tagging method provides bioadhesive interface for marine sensors on diverse, soft, and fragile specieson April 15, 2024 at 5:00 pm
A newly developed soft hydrogel-based bioadhesive interface for marine sensors, referred to as BIMS, holds promise as an effective, rapid, robust, and non-invasive method to tag and track all ...
- Novel hydrogel removes microplastics from wateron April 11, 2024 at 5:00 pm
The hydrogel was found to be highly efficient—it could remove about 95% and 93% of the two different types of microplastics in water at near-neutral pH (∼6.5).
- Novel antibiotic-infused hydrogel kills bacteria and promotes cell growthon April 1, 2024 at 5:00 pm
In tests with E. coli and S. aureus, the bacterium that causes staph infection, the hydrogel damaged bacteria cell membranes and led to bacterial cell death. For healthy cells, the inclusion of ...
via Bing News