The first dengue vaccine candidate (CYD-TDV) to reach phase 3 clinical testing has shown moderate protection (56%) against the disease in Asian children, according to new research published in The Lancet.
Dengue is a mosquito-borne disease that infects around 390 million people each year, of whom about 96 million suffer from symptomatic infection. WHO estimates that the global burden of dengue has risen 30-fold over the past 50 years, with over half of the world’s population at risk of the disease.
There is no licensed vaccine available to treat or prevent dengue fever, and efforts to develop one have been complicated by the fact that dengue is caused by four distinct dengue viruses, and a vaccine must target all four serotypes (DENV 1–4).
This phase 3 trial took place in dengue-endemic areas across five countries in Asia, a region that accounts for over 70% of the global dengue burden. The study involved 10 275 healthy children aged 2 to 14 years who were randomly assigned to receive three injections of the CYD-TDV vaccine (6851) or a placebo (3424) at 0, 6, and 12 months, and followed for up to 2 years.
The researchers recorded 250 dengue cases more than 28 days after the third injection—117 in the vaccine group and 133 in the placebo group, demonstrating an overall protective efficacy of 56.5%.
The vaccine also showed 88.5% efficacy after 3 doses against severe disease (dengue haemorrhagic fever) which leads to hospitalisation for over half a million people (mostly children) every year, and 67% against dengue-associated hospitalisation.
Read more . . .
The Latest on: Dengue vaccine
[google_news title=”” keyword=”Dengue vaccine” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Dengue vaccine
- Japanese vaccine against dengue approved for use in Argentinaon May 9, 2024 at 4:59 pm
The vaccine, called TAK-003, is based on dengue virus 2, to which DNA from the other three serotypes is added to protect against any of the four types of dengue, it was explained.
- Indian ocean temperature anomalies predict global dengue trendson May 9, 2024 at 11:13 am
Dengue – a mosquito-borne flavivirus disease – affects nearly half the world’s population. Currently, there are no specific drugs or vaccines for the disease, and outbreaks can have serious public ...
- How to avoid catching dengue fever in Balion May 8, 2024 at 5:24 am
If you’re at risk, get the vaccine Officials in Bali are now encouraging tourists to get the dengue fever vaccine before travelling to the island. However, in Australia, the Dengvaxia vaccine is ...
- ‘Make dengue vaccine affordable’on May 7, 2024 at 5:00 pm
PETALING JAYA: The Qdenga dengue vaccine must be reasonably priced and be easily accessible to Malaysians given the high burden of the disease in Asia, says virologist Emeritus Prof Datuk Dr Lam ...
- Dengue is now endemic in more than 100 countries—here's what you need to knowon May 6, 2024 at 10:15 am
Over the last 20 years, there has been a tenfold increase in reports of dengue—an infectious disease that spreads to humans through the bite of infected Aedes aegypti and Aedes albopictus mosquitoes.
- Global Dengue Vaccines Industry Poised for Explosive Growth at Double-Digit CAGR, Reaching USD1.6 Billion by 2033on May 6, 2024 at 5:00 am
Global Dengue Vaccines Industry s expected to be worth of US$ 1,603.7 Million during forecast period 2023 to 2033 at 12.9% CAGR ...
- Dengue vaccine: People sceptical due to stigmaon May 4, 2024 at 4:00 am
Two months ago, the Health Ministry granted conditional approval for Qdenga, a dengue vaccine, as cases soared nationwide. However, many are still sceptical about the vaccine as it is new in the ...
- What led to Latin America’s record dengue surgeon May 3, 2024 at 8:10 am
While some countries are witnessing a surge in dengue much before the peak season, others are recording severe outbreaks for the first time. Here is a look at the situation ...
- Dengue fever symptoms changed in COVID-19 survivors: Ministryon May 3, 2024 at 2:09 am
The Health Ministry confirmed changes in the symptoms of Dengue Hemorrhagic Fever (DBD) among persons who had contracted COVID-19 due to the influence of ...
- Taking dengue vaccine is still optional for public: Officialon May 2, 2024 at 4:44 am
DKI Jakarta Health Service's Surveillance, Epidemiology, and Immunization Department Head, Budi Setiawan, stated that the dengue vaccine is still optional ...
via Bing News