Wellcome Trust Sanger Institute

The Wellcome Trust Sanger Institute (previously known as ‘The Sanger Centre’) is a non-profit, British genomics and genetics research institute, primarily funded by the Wellcome Trust.

The first ever vaccine target for a family of parasites that cause devastating disease in millions of animals and humans has been discovered

Could a new malaria discovery offer effective treatment for a range of infectious diseases including COVID-19?

DNA fingerprints could catch cancer-causing culprits

Tailor-made vaccines could cut the rates of serious bacterial diseases in half

Boosting research into development and regenerative medicine with a major stem cell discovery

Expanded Potential Stem Cell lines of pig and human cells established A new approach has enabled researchers to create Expanded Potential Stem Cells (EPSCs) of both pig and human cells. These stem cells have the features of the very first cells in the developing embryo, and can develop into any type of cell. The research

Boosting research into development and regenerative medicine with a major stem cell discovery

A promising new treatment for acute myeloid leukaemia

Ingredient in pre-clinical treatment for retinal neovascular disease targets gene associated with acute myeloid leukaemia An active ingredient in eye drops that were being developed for the treatment of a form of eye disease has shown promise for treating an aggressive form of blood cancer. Scientists at the Wellcome Sanger Institute, University of Cambridge, University

A promising new treatment for acute myeloid leukaemia

A prediction tool for gene editing

Prediction resource could make CRISPR-Cas9 editing more reliable The largest study of CRISPR action to date has developed a method to predict the exact mutations CRISPR-Cas9 gene editing can introduce to a cell. Researchers at the Wellcome Sanger Institute edited 40,000 different pieces of DNA and analysed a thousand million resulting DNA sequences to reveal

A prediction tool for gene editing

Novel genes for osteoarthritis have been discovered that could lead to targeted therapies

The results could open the door to new targeted therapies for this debilitating disease in the future In the largest study of its kind, nine novel genes for osteoarthritis have been discovered by scientists from the Wellcome Sanger Institute and their collaborators. Results of the study, published today (19 March) in Nature Genetics, could open the door

Novel genes for osteoarthritis have been discovered that could lead to targeted therapies

Microreact, a free, real-time epidemic visualisation and tracking platform that has been used to monitor outbreaks of Ebola, Zika and antibiotic-resistant microbes

Researchers from the Wellcome Trust Sanger Institute and Imperial College London have developed Microreact, a free, real-time epidemic visualisation and tracking platform that has been used to monitor outbreaks of Ebola, Zika and antibiotic-resistant microbes. The team have collaborated with the Microbiology Society to allow any researcher around the world to share their latest information

Microreact, a free, real-time epidemic visualisation and tracking platform that has been used to monitor outbreaks of Ebola, Zika and antibiotic-resistant microbes

Bugs as drugs have the guts

Harnessing novel gut bacteria for human health Scientists at the Wellcome Trust Sanger Institute have grown and catalogued more than 130 bacteria from the human intestine according to a study published in Nature today (Wednesday May 4, 2016). The researchers have developed a process to grow the majority of bacteria from the gut, which will

Bugs as drugs have the guts

3-D ‘organoids’ grown from patient tumors could personalize drug screening

Three-dimensional cultures (or “organoids”) derived from the tumors of cancer patients closely replicate key properties of the original tumors, reveals a study published May 7 in Cell. These “organoid” cultures are amenable to large-scale drug screens for the detection of genetic changes associated with drug sensitivity and pave the way for personalized treatment approaches that

3-D ‘organoids’ grown from patient tumors could personalize drug screening

UEA research could revolutionise genomic sequencing of drug-resistant bacteria

New nanopore DNA sequencing technology on a device the size of a USB stick could be used to diagnose infection – according to new research from the University of East Anglia and Public Health England. Researchers tested the new technology with a complex problem – determining the cause of antibiotic resistance in a new multi-drug

UEA research could revolutionise genomic sequencing of drug-resistant bacteria

Scientists discover how to ‘switch off’ autoimmune diseases

Scientists have made an important breakthrough in the fight against debilitating autoimmune diseases such as multiple sclerosis by revealing how to stop cells attacking healthy body tissue. Rather than the body’s immune system destroying its own tissue by mistake, researchers at the University of Bristol have discovered how cells convert from being aggressive to actually

Scientists discover how to ‘switch off’ autoimmune diseases

New epilepsy treatment offers ‘on demand’ seizure suppression

A new treatment for drug-resistant epilepsy with the potential to suppress seizures ‘on demand’ with a pill, similar to how you might take painkillers when you feel a headache coming on, has been developed by UCL researchers funded by the Wellcome Trust. The treatment, described in Nature Communications, combines genetic and chemical approaches to suppress

New epilepsy treatment offers ‘on demand’ seizure suppression

Artificial blood ‘will be manufactured in factories’

Wellcome Trust-funded stem cell research has produced red blood cells fit for transfusion into humans, paving the way for the mass production of blood It is the stuff of gothic science fiction: men in white coats in factories of blood and bones. But the production of blood on an industrial scale could become a reality

Artificial blood ‘will be manufactured in factories’

Scots scientists make major breakthrough on malaria

A MALARIA breakthrough by Scots researchers could pave the way to new drug treatments able to prevent transmission of the disease. A study by scientists at Glasgow University and the Wellcome Trust Sanger Institute, near Cambridge, has unlocked the long-standing mystery of how the malaria parasite initiates the process of passing from human to human.

Scots scientists make major breakthrough on malaria

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Wellcome Trust Sanger Institute Research
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