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University of Massachusetts Medical School (UMMS)

August 1, 2019

The University of Massachusetts Medical School (UMMS) is one of five campuses of the University of Massachusetts (UMass) system.

RNA-delivery particles can perform gene editing in the lungs

RNA-delivery particles can perform gene editing in the lungs

Could nanoparticles eventually give built-in night vision to humans?

Movies featuring heroes with superpowers, such as flight, X-ray vision or extraordinary strength, are all the rage. But while these popular characters are mere flights of fancy, scientists have used nanoparticles to confer a real superpower on ordinary mice: the ability to see near-infrared light. Today, scientists report progress in making versions of these nanoparticles

Could nanoparticles eventually give built-in night vision to humans?

What if you can reprogram the DNA of your liver while you’re still using it?

New delivery system developed by MIT team deletes disease-causing genes and reduces cholesterol. In a new study, MIT researchers have developed nanoparticles that can deliver the CRISPR genome-editing system and specifically modify genes in mice. The team used nanoparticles to carry the CRISPR components, eliminating the need to use viruses for delivery. Using the new

What if you can reprogram the DNA of your liver while you’re still using it?

An anti-CRISPR could prevent off-target effects

Researchers have discovered a way to program cells to inhibit CRISPR-Cas9 activity. “Anti-CRISPR” proteins had previously been isolated from viruses that infect bacteria, but now University of Toronto and University of Massachusetts Medical School scientists report three families of proteins that turn off CRISPR systems specifically used for gene editing. The work, which appears December

An anti-CRISPR could prevent off-target effects

Curing disease by repairing faulty genes with CRISPR

New delivery method boosts efficiency of CRISPR genome-editing system The genome-editing technique known as CRISPR allows scientists to clip a specific DNA sequence and replace it with a new one, offering the potential to cure diseases caused by defective genes. For this potential to be realized, however, scientists must find a way to safely deliver

Curing disease by repairing faulty genes with CRISPR

Tuning light to kill deep cancer tumors

Nanoparticles developed at UMass Medical School advance potential clinical application for photodynamic therapy for cancer An international group of scientists led by Gang Han, PhD, has combined a new type of nanoparticle with an FDA-approved photodynamic therapy to effectively kill deep-set cancer cells in vivo with minimal damage to surrounding tissue and fewer side effects

Tuning light to kill deep cancer tumors

Draper Nanotechnology Could Fight Influenza, Other Viruses

Further into the future, patients suffering from any type of virus could be cured with DRACO Newly emerging flu viruses could soon be countered by a treatment that Draper Laboratory is developing that “traps” viruses before they can infect host cells. Further into the future, patients suffering from any type of virus could be cured

Draper Nanotechnology Could Fight Influenza, Other Viruses

Stem cell research yields Down syndrome breakthrough

“This appears to be one of the most important scientific advancements in the field since French physician Jerome Lejeune identified Down syndrome as a chromosomal condition in 1959,” Two UMass Medical School researchers used a naturally occurring “off switch” to shut down the chromosomes that cause Down syndrome during laboratory experiments that used human stem cells, according

Stem cell research yields Down syndrome breakthrough

Bitter Taste May Battle Asthma

Bitter substances block calcium channels, which can relax the tissue that tightens up during asthma attacks. People with asthma, chronic obstructive pulmonary disease and other breathing disorders need fast relief when their airways tighten up. Unfortunately, the most commonly used medication has obnoxious side effects. But scientists recently discovered that a bitter taste can be

Bitter Taste May Battle Asthma

The battery of the future might run on sugar

It seems that sugar may be the missing ingredient for building rechargeable batteries that are more robust, cheaper, and capable of storing more energy. Researchers at the Tokyo University of Science have turned to sugar as part of a continuous effort to control Japan’s growing import costs associated with building lithium-ion batteries. Lithium-ion batteries are

The battery of the future might run on sugar

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