Microscopic image showing brown, antibody-based staining of keratin 17 (K17) in bladder cancer.
Credit: Shroyer Lab, Stony Brook University
A novel urine screening test that uses a protein, keratin 17 (K17), as a cancer biomarker reveals the test detects the presence of new or recurrent cases of bladder cancer.
The methodology behind the test stems from research at Stony Brook University led by Kenneth Shroyer, MD, PhD. A study that details the finding of the test is published in the American Journal of Clinical Pathology.
Some 81,000 cases of bladder cancer are diagnosed in the United States each year according to the American Cancer Society. Accurate detection of bladder cancer, or urothelial carcinoma (UC), is often difficult, expensive and involves invasive testing. Going forward, this new method, based on the detection of K17 in urine specimens, could help guide treatment by improving diagnostic accuracy.
“It is important to find new biomarkers to more accurately detect UC since standard methods used in most cytology labs are based primarily on microscopic details that do not always clearly distinguish cancer from benign cells,” explains Dr. Shroyer, the Marvin Kuschner Professor and Chair of Pathology at the Renaissance School of Medicine at Stony Brook University and inventor of the K17 test.
Previously, Dr. Shroyer and his colleague, Dr. Luisa Escobar-Hoyos (an Assistant Professor at Yale), co-directed a team of Stony Brook University students and collaborators to demonstrate that K17 is a highly sensitive and specific biomarker for UC in tissue biopsy and surgical specimens. The current published study builds on these findings to show that K17 testing could also be performed as a non-invasive test on urine specimens.
Using various urine sample sets, the Stony Brook team found that the urine K17 test detected UC in 35/36 (97 percent) of cases that were confirmed by biopsy, including 100 percent of cases with high-grade UC.
From these results and other findings based on the testing, the authors conclude that K17 testing is a highly sensitive and specific diagnostic test for initial screening and for detection of recurrence across all grades of UC.
Dr. Shroyer and his colleagues believe the potential of this test as a non-invasive way to detect UC will help to transform not only diagnostic practices but earlier treatment intervention and prognosis of UC.
The K17 test is being developed commercially by KDx Diagnostics, Inc., a start-up biotech company, which has a license with The Research Foundation for The State University of New York.
Recently, KDx has been awarded a breakthrough device designation from the Food and Drug Administration for its assay test with K17.
For years, the Shroyer lab, in collaboration with Dr. Luisa Escobar-Hoyos, has been exploring K17 as a biomarker for various cancers, including UC and pancreatic cancer. Furthermore, the research team continues to advance the understanding of how K17, once thought to be only a structural protein, fundamentally impacts numerous hallmarks of cancer.
Original Article: New Non-Invasive Test Can Detect Bladder Cancer
More from: Stony Brook University | Yale University
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
Non-invasive test for bladder cancer
- Knoxville residents can try a new blood test to screen for cancer before a colonoscopy
ColoHealth is the next generation of the first and only FDA-approved blood test for colorectal cancer screening, Epi proColon, and it looks for altered DNA associated with the cancer. New ...
- U.K. Tests World-First Personalized Skin Cancer Vaccine
Customized with genetic information from a patient’s own tumor, vaccines like this could one day be used against lung, kidney, bladder and colon cancer.
- FDA Approves New Bladder Cancer Drug
The first-in-class agent is approved alongside bacillus Calmette-Guérin to treat certain non–muscle-invasive bladder cancers that do not respond to bacillus Calmette-Guérin alone.
- Urine-based test detects head and neck cancer
While the initial study focused on head and neck cancer, the team also analyzed urine samples of people with other cancers, such as breast and acute myeloid leukemia, and found that ultrashort ...
- Patrick Soon-Shiong's ImmunityBio bags FDA approval for Anktiva to challenge Merck in bladder cancer
ImmunityBio has yet to finalize a registrational trial plan with the FDA in that papillary disease population, Soon-Shiong said. Still, Adcock said “the one to look at” is in the treatment-naïve ...
Go deeper with Google Headlines on:
Non-invasive test for bladder cancer
[google_news title=”” keyword=”non-invasive test for bladder cancer” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]
Go deeper with Bing News on:
Bladder cancer
- Will Gilead's Big Veklury Beat Offset A Cancer Drug Miss?
Gilead beat first-quarter calls, but it came on the back of Covid drug Veklury. And Gilead stock could take hit Thursday.
- Bristol Myers Gets CHMP Backing for Opdivo Combo in Bladder Cancer
By Colin Kellaher Bristol Myers Squibb on Friday said the European Medicines Agency's Committee for Medicinal Products for Human Use recommended
- World’s first jab to stop skin cancer brings hope for patients
Dr Heather Shaw, national co-ordinating investigator, says the jab is being tested to see if it can work for lung, bladder and kidney cancer
- DJ event at Hideout in Warrington to fundraise for Bladder Cancer UK
A WOMAN is holding a DJ event to raise awareness of bladder cancer after her best friend was diagnosed with the condition.
- Anktiva Approved for BCG-Unresponsive Non-Muscle Invasive Bladder Cancer
The Food and Drug Administration (FDA) has approved Anktiva ® (nogapendekin alfa inbakicept-pmln) with Bacillus Calmette-Guérin (BCG) for adult patients with BCG-unresponsive non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ (CIS ...
Go deeper with Google Headlines on:
Bladder cancer
[google_news title=”” keyword=”bladder cancer” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]