The research may contribute to the development of more effective drugs against malaria
Researchers from the Universitat Politècnica de Catalunya · BarcelonaTech (UPC), the Instituto de Química Mèdica (IQM-CSIC) and the University of Glasgow have proved that the CD27 drug is a true alternative against malaria.
They have analysed the crystalline structure of the DNA with the drug by performing X-ray diffraction experiments at the ALBA synchrotron.
An international group of researchers led by Lourdes Campos from the Department of Chemical Engineering at the Universitat Politècnica de Catalunya · BarcelonaTech (UPC) has proved that the CD27 drug can be a reliable option against malaria. Researchers came to this conclusion after studying the 3D crystalline structure of the complex of DNA with the drug.
The CD27 drug is a complex synthesised by researchers led by Christophe Dardonville at the Instituto de Química Médica of the Spanish National Research Council’s/ (IQM-CSIC) in Madrid. “CD27 is chemically related to diamidines – molecules with two amidines – and has previously been used with success in other Trypanosoma species that produce the ‘sleeping sickness’ in Africa and Chagas disease in South America”, says Lourdes Campos. Results show how the CD27 drug completely covers the minor groove of the DNA, preventing the typical development of the parasite and causing its death. This research helps to understand this family of compounds and may significantly contribute to the development of new, more effective drugs against malaria.
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