Tokyo Medical and Dental University

The newly developed antibody 6H4 fragments (Fabs) specific to A? oligomers, encapsulated in the polymeric nanomicelles (PMs), were peripherally administrated to AD model mouse for 10 weeks. In mice that were administered anti-A?O 6H4 Fabs in the PMs, various toxic A? species (A? oligomers, A?42s, N3pE A?s, A?s with toxic conformer) and the presence of A? plaques with dense cores in the brain were significantly reduced. Additionally, suppression of the progression of pathological processes of AD was supported by the prevention of cognitive-behavioral decline in the spatial memory tests. CREDIT Department of Neurology and Neurological Science, TMDU

Crossing the blood–brain barrier to deliver antibodies to treat Alzheimer’s disease

Ion-sensitive field effect transistors detect breast cancer cells expressing EGFR when bound by an antibody linked to a chemical reporter CREDIT Department of Bioelectronics, TMDU

Making testing for cancer a lot less invasive by using transistors instead of biopsies

LAMZ augments muscle and bone by mimicking calcium signaling to induce PGC-1? Exercise induces calcium signaling in the muscle and bone. Under this signaling, PGC-1? is activated, resulting in the augmentation of these tissues. LAMZ, a newly identified locomomimetic drug was found to facilitate the calcium signaling pathway and restores locomotor fitness.

Strengthening muscle and bone with a pill

A novel voltage-based biosensor for the influenza virus that is almost 100 times more sensitive than conventional tests