Chemists and biologists at UC San Diego have succeeded in designing and synthesizing an artificial cell membrane capable of sustaining continual growth, just like a living cell.
Their achievement, detailed in a paper published in this week’s issue of the Proceedings of the National Academy of Sciences,will allow scientists to more accurately replicate the behavior of living cell membranes, which until now have been modeled only by synthetic cell membranes without the ability to add new phospholipids.
“The membranes we created, though completely synthetic, mimic several features of more complex living organisms, such as the ability to adapt their composition in response to environmental cues,” said Neal Devaraj, an assistant professor of chemistry and biochemistry at UC San Diego who headed the research team, which included scientists from the campus’ BioCircuits Institute.
“Many other scientists have exploited the ability of lipids to self-assemble into bilayer vesicles with properties reminiscent of cellular membranes, but until now no one has been able to mimic nature’s ability to support persistent phospholipid membrane formation,” he explained. “We developed an artificial cell membrane that continually synthesizes all of the components needed to form additional catalytic membranes.”
Read more: Scientists Create Synthetic Membranes That Grow Like Living Cells
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