Learning requires the chemical adaptation of individual synapses. Researchers have now revealed the impact of an RNA-binding protein that is intimately involved in this process on learning and memory formation and learning processes.
The formation of memories requires subtle changes in brain structures. This is because learning and memory are the result of the incessant modification of synapses – which provide the functional connections that enable nerve cells to communicate with one another. The long-term molecular alterations involved in this process are encoded by so-called messenger RNAs, which are produced in the nucleus of the neuron and must be transported to the appropriate synapses in order to program the synthesis of specific proteins “on-site”. In previous studies, LMU scientist Michael Kiebler has shown that the RNA-binding protein Staufen2 plays an essential role in conveying these mRNAs to their destinations. But exactly how this molecular process actually affects learning and behavior was not well understood. Now, a study carried out by the Kiebler group, in collaboration with Dusan Bartsch (Mannheim University) and Spanish colleagues (Seville University), has shed new light on this issue. The new work shows, for the first time, that reduced levels of Staufen2 are associated with a specific impairment of memory. The findings appear in the journal Genome Biology.
The researchers made use of a genetic rat model that has been developed and refined over the past decade, in which the synthesis of Staufen2 can be conditionally and selectively suppressed in nerve cells in the forebrain. They then characterized the effects of reduced levels of Staufen2 protein on memory using behavioral tests that measure the efficacy of spatial, temporal and associative memory. These tasks are known to depend on synaptic plasticity, i.e. the ability to actively adjust the efficiency of communication between specific synaptic networks, in the hippocampus. The results clearly show that the reduction of Staufen2 in the forebrain has a negative impact on several aspects of memory. “Overall, long-term memory continues to function, and the rats remain capable of learning how to find a food source, for instance” – Kiebler says – “but when the mutants are asked to recall what they have learned after longer periods of time, their performance is significantly worse than wild-type animals.”
Depletion of Staufen2 also has a marked effect on nerve-cell morphology and synapse function. With the aid of electrophysiological measurements, the authors analyzed the efficiency of signal transmission across synapses in the hippocampus, and found that both long-term potentiation (LTP) and long-term depression (LTD) are affected. LTP is a mechanism that results in a long-lasting increase in the efficiency of synaptic transmission, and thus strengthens the functional connections between them. LTD, on the other hand, diminishes transmission efficacies, and effectively disconnects previously established connections. Strikingly, reduced levels of Staufen2 enhance LTP, while they impair LTD. These findings suggest that deficiency of Staufen2 makes synapses more responsive than they would otherwise be. “LTP is regarded as a model of learning at the cellular level. However, our results indicate that it is actually the balance of LTP to LTD that is important. This is clearly perturbed in the absence of Staufen2”, Kiebler points out. The researchers therefore assume that, under these circumstances, synapses become highly responsive, and not enough are repressed. This could imply that information which is normally consolidated in long-term memory is prematurely destabilized or perhaps even wiped out. “This work has enabled us, for the first time, to link a specific molecular factor – the RNA-binding protein Staufen2 – with synaptic plasticity and learning,” Kiebler says. “Furthermore, our approach promises to yield completely new insights into the molecular mechanisms that mediate learning.”
Genome Biology 2017
The Latest on: Chemistry of memory
[google_news title=”” keyword=”chemistry of memory” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
- Enhancing memory technology: Multiferroic nanodots for low-power magnetic storageon April 26, 2024 at 9:10 am
Traditional memory devices are volatile and the current non-volatile ones rely on either ferromagnetic or ferroelectric materials for data storage. In ferromagnetic devices, data is written or stored ...
- Innovative Microscopy Demystifies Metabolism of Alzheimer’son April 24, 2024 at 10:22 am
State-of-the-art imaging techniques uncover metabolism driving Alzheimer’s disease, potential new treatment strategies ...
- ‘Like kissing Hitler’: The stars who failed Hollywood’s ‘chemistry test’on April 24, 2024 at 7:00 am
Imagine, for a moment, that you’re an actress at the beginning of your career. You’ve been acclaimed for your performances on stage – your Ophelia was the talk of the National Theatre, and your ...
- Minnesota farmers welcome spring rain: 'There's nothing like the chemistry of rainwater'on April 16, 2024 at 1:25 pm
"There's nothing like the chemistry of rainwater," Rudebusch said ... "But they weren't enough to replenish the soils." Her good memory recalls last April and May when oscillating rain and snowfall ...
- Grave of household fridge scientist restoredon April 11, 2024 at 10:36 pm
Prof Thomas Andrews' gravestone is restored to ensure his scientific developments are remembered ...
- Scientists harness chemical dynamics for complex problem solvingon April 4, 2024 at 5:00 pm
At the intersection of chemistry and computation ... that are used to create logic gates and memory cells, forming the basis of digital circuits. But, the need and demand for more computational ...
- What to know about medications for memory losson April 3, 2024 at 5:00 pm
Health experts recommend that those with memory loss follow doctor-approved prescriptions only. Acetylcholine is a neurotransmitter, or chemical messenger, that plays a vital role in memory and ...
- Agriculture & Foodon May 26, 2021 at 1:21 pm
Success in the field of agriculture and food chemistry requires motivation and tenacity ... Food and flavor chemists need excellent senses of smell and taste and good odor memory. The common goal of ...
- The Wells of Memoryon February 18, 2021 at 8:25 am
There are wells whose waters convey the chemistry of sadness or joy ... But I have never been to a place more memory-less. A small, bottomless well in the Hejaz: a white porcelain cup.
- Chemistry scholarshipson August 18, 2020 at 6:13 am
The scholarship has been continuously funded since then with donations from the Chemistry faculty. Mr. Ben A. Edwards of Reno established a testamentary trust that provides funding for scholarships in ...
via Google News and Bing News