Chronic inflamation, closely associated with frailty and age-related diseases, is a hallmark of aging. Mayo Clinic researchers have discovered that inhibiting key enzyme pathways reduces inflammation in human cells in culture dishes and decreases inflammation and frailty in aged mice.
The results appear today in Proceedings of the National Academy of Sciences of the United States of America. While further studies are needed, researchers are hopeful that these findings will be a step toward treatments for frailty and other age-related chronic conditions.
In the study, researchers found that Janus kinase (JAK) inhibitors, drugs that work to block activity of JAK enzymes, decreased the factors released by human senescent cells in culture dishes. Senescent cells are cells that contribute to frailty and diseases associated with aging. Also, these same JAK inhibitors reduced inflammatory mediators in mice. Researchers examined aged mice, equivalent to 90-year-old people, before and after JAK inhibitors. Over the course of two months, the researchers found substantial improvement in the physical function of the aged mice, including grip strength, endurance and physical activity.
Read more: Researchers reduce inflammation in human cells, A major cause of frailty
The Latest on: Chronic inflammation
[google_news title=”” keyword=”chronic inflammation” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Chronic inflammation
- Intermittent fasting protects against liver inflammation, liver cancer: Studyon May 9, 2024 at 5:18 am
Intermittent fasting has been found in multiple studies to be an effective way to lose weight and alleviate some metabolic disorders. Heikenwalder's team has now investigated in mice if this method ...
- Intermittent fasting protects against liver inflammation and liver cancer, claims studyon May 8, 2024 at 6:31 pm
Fatty liver disease often leads to chronic liver inflammation and can even result in liver cancer. Scientists from the German Cancer Research Center (DKFZ) and the University of Tübingen have ...
- Chronic inflammation: Avoid these foods to stay healthy and fiton May 8, 2024 at 4:12 am
It's a complex biological process involving the immune system, blood vessels, and various signaling molecules. Here are certain foods which can exacerbate inflammation. So, avoiding or minimising them ...
- 5:2 fasting diet's anti-inflammatory effects come down to two proteinson May 8, 2024 at 12:38 am
A 5:2 intermittent fasting regime – eating for five days, fasting for two – protected against liver inflammation and didn’t cause weight gain, say researchers, who also identified the proteins that ...
- Investigational Drugs for Chronic Inflammatory Demyelinating Polyneuropathyon May 7, 2024 at 9:00 pm
Investigational therapies may soon change the treatment landscape for chronic inflammatory demyelinating polyneuropathy (CIDP)."Despite the fact that we have some good standard-of-care therapies -- ...
- Do you know intermittent fasting protects against liver inflammation, liver cancer? Study findson May 7, 2024 at 12:02 pm
Fatty liver disease frequently causes chronic liver inflammation and can possibly result in liver cancer. Scientists at the German Cancer Research Centre (DKFZ) and the University of Tubingen have ...
- 7 Worst Inflammatory Foods Doctors Say Make Weight Loss 'So Much Harder': Sugary Condiments & Moreon May 7, 2024 at 11:30 am
Certain foods are notorious for their inflammatory properties, potentially making weight management more challenging and increasing the risk of chronic diseases. These “worst inflammatory foods” often ...
- Intermittent fasting protects against liver inflammation and liver canceron May 6, 2024 at 4:59 pm
Fatty liver disease often leads to chronic liver inflammation and can even result in liver cancer. Scientists from the German Cancer Research Center (DKFZ) and the University of Tübingen have now ...
- Study Links High Ultra-Processed Food Intake to Increased Risk of Death from Chronic Respiratory Diseaseson May 6, 2024 at 1:04 pm
Although chronic respiratory diseases remain the third leading cause of mortality, they have received less attention from the global community.
- The #1 Thing to Avoid If You Have Chronic Inflammation, According to Dietitianson May 6, 2024 at 12:27 pm
You may think of it as an emotional issue, but it also has physical repercussions. Getty Images Reviewed by Dietitian Maria Laura Haddad-Garcia Chronic inflammation plays a central role in the ...
via Bing News