Niacin, the fountain of youth

via ETH Zurich

The vitamin niacin has a life-prolonging effect, as Michael Ristow has demonstrated in roundworms.

From his study, the ETH-Zurich professor also concludes that so-called reactive oxygen species are healthy, not only disagreeing with the general consensus, but also many of his peers.

Who would not want to live a long and healthy life? A freely available food supplement could help in this respect, scientists from ETH Zurich have demonstrated in roundworms. Vitamin B3 – also known as niacin – and its metabolite nicotinamide in the worms’ diet caused them to live for about one tenth longer than usual.

As an international team of researchers headed by Michael Ristow, a professor of energy metabolism, has now experimentally demonstrated, niacin and nicotinamide take effect by promoting formation of so-called free radicals. “In roundworms, these reactive oxygen species prolong life,” says Ristow.

“No scientific evidence for usefulness of antioxidants”

This might seem surprising as reactive oxygen species are generally considered to be unhealthy. Ristow’s view also contradicts the textbook opinion championed by many other scientists. Reactive oxygen species are known to damage somatic cells, a condition referred to as oxidative stress. Particular substances, so-called antioxidants, which are also found in fruit, vegetables and certain vegetable oils, are capable of neutralising these free radicals. Many scientists believe that antioxidants are beneficial to health.

“The claim that intake of antioxidants, especially in tablet form, promotes any aspect of human health lacks scientific support,” says Ristow. He does not dispute that fruit and vegetables are healthy. However, this may rather be caused by other compounds contained therein, such as so-called polyphenols. “Fruit and vegetables are healthy, despite the fact that they contain antioxidants,” says the ETH-Zurich professor. Based on the current and many previous findings he is convinced that small amounts of reactive oxygen species and the oxidative stress they trigger have a health-promoting impact. “Cells can cope well with oxidative stress and neutralise it,” says Ristow.

Substance mimics endurance sport

In earlier studies on humans, Ristow demonstrated that the health-enhancing effect of endurance sports is mediated via an increased formation of reactive oxygen species – and that antioxidants abolish this effect. Based on the present study, he concludes that niacin brings about a similar metabolic condition to exercise. “Niacin tricks the body into believing that it is exercising – even when this is not the case,” says Ristow. Such compounds are known as “exercise mimetics”.

The researchers conducted their experiments on the model organism Caenorhabditis elegans. This worm, which is merely one millimetre in length, can be easily maintained and has a lifespan of only a month, making it the ideal model organism for ageing research.

Also relevant for humans

The results of the study may also be of relevance for humans, says Ristow. After all, the metabolic pathway initiated by niacin is very similar in roundworms and higher organisms. Whether niacin has similar effects on the life expectancy of mice is the subject of Ristow’s current research. Previous studies also suggest a health-enhancing effect of niacin in humans with elevated blood cholesterol levels.

See Also

Niacin and nicotinamide have been approved as dietary supplements for decades. Ristow could easily envisage the substances being used broadly for therapeutic purposes in the future. A whole series of foods naturally contain niacin, including meat, liver, fish, peanuts, mushrooms, rice and wheat bran. Whether nutritional uptake is sufficient for a health-enhancing or lifespan-extending effect, however, remains to be demonstrated, says Ristow.

Read more . . .

 

 

The Latest Bing News on:
Niacin
  • When is peach season in SC, Upstate? Here's what to know about peach types, benefits.
    on May 24, 2024 at 11:48 am

    Annually, the state produces 132 million pounds of peaches. Overall, peaches are an $80 million industry in S.C., according to the South Carolina Peach Council. Multiple reports have forecast a strong ...

  • Boost your morning with these dishes loaded with B vitamins
    on May 23, 2024 at 11:17 pm

    Quinoa, a complete protein, is rich in B vitamins, perfect for this nutritious bowl. Combined with fresh spinach, it adds folate, essential for brain health. Topped with creamy avocado for vitamin B5 ...

  • Effects of Niacin on LDL Particle Number
    on May 22, 2024 at 5:00 pm

    Niacin has long been used as an effective lipid-altering therapy, particularly for raising HDL-C and lowering triglyceride levels. In addition, niacin modestly lowers LDL-C levels. LDL-C ...

  • Effects of Niacin on LDL Particle Number
    on May 21, 2024 at 5:00 pm

    This study is planned to randomize approximately 3300 people to either simvastatin or simvastatin–niacin over the course of 5–6 years. [101] The premise of the study is that, even with statin ...

  • 4 Science-Based Benefits of Niacin (Vitamin B3)
    on May 17, 2024 at 5:00 pm

    Niacin is a type of B vitamin that offers benefits for you whole body, from your brain to your skin. You can get it from meat, fish, and nuts, or in supplement form. Niacin, also known as vitamin ...

  • ‘I'm a Cardiologist and This Is the Vegetable I Eat Almost Every Day for Heart Health’
    on May 14, 2024 at 3:25 am

    It’s not a coincidence that only 10% of adults in the U.S. are eating the recommended daily vegetable intake (two to three cups per day) and heart disease is the country’s leading cause of death.

  • Niacin News and Research
    on April 14, 2024 at 5:00 pm

    Cleveland Clinic researchers have identified a new pathway that contributes to cardiovascular disease associated with high levels of niacin, a common B vitamin previously recommended to lower ...

  • 8 Foods high in Niacin that can reduce your Cholesterol Levels
    on February 28, 2024 at 3:36 am

    Niacin (also known as Vitamin B3) plays many roles in our body. Therefore, foods high in niacin are important for the body. Since niacin is a water-soluble vitamin, our body cannot store it; excess is ...

  • Niacin is a critical B vitamin but you should know this before you take it
    on February 22, 2024 at 10:37 am

    But what about B3 or niacin? Are you familiar with it? It's a key molecule that helps with all kinds of bodily functions. While niacin works all over the body, it is known for being particularly ...

  • FAQ NIACIN
    on February 25, 2021 at 6:43 am

    Please find below answers to some of the questions raised by the recent publication "Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy” by the ...

The Latest Google Headlines on:
Niacin

[google_news title=”” keyword=”Niacin” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]

The Latest Bing News on:
Exercise mimetics
  • Does the perfect workout really exist?
    on May 21, 2024 at 5:00 pm

    Soon after, Cure, a fitness enthusiast and part-time roller skating instructor in Chicago, launched Chainless Movements, a group rebound class that resembles step aerobics on space-age stilts.

  • Exercise and Sports Medicine
    on May 21, 2024 at 5:00 pm

    Diet and Exercise in a Pill Are Real: How Mimetics Work Drugs that mimic physical activity and calorie restriction in the body are on their way. How do they work — and how will they help?

  • 7 Kettlebell Exercises to Include in Your Workout
    on May 20, 2024 at 5:01 pm

    They can help improve your strength, power, and cardiovascular fitness. Kettlebells are a popular strength-training alternative to traditional barbells, dumbbells, and resistance machines.

  • Steps vs. minutes: study reveals best way to track exercise
    on May 20, 2024 at 9:11 am

    Researchers at Brigham and Women's Hospital evaluated whether it's better to measure exercise goals in minutes or steps. bignai - stock.adobe.com Just for good measure, researchers at a Boston ...

  • When Is The Best Time Of Day To Exercise?
    on May 15, 2024 at 11:29 pm

    Think of it this way: If you’re getting up before sunrise to exercise but you’re not typically an early riser, your body may feel a little sluggish, slow to react and weaker than if you ...

  • We've tested the best exercise bikes to help you boost your fitness at home
    on May 2, 2024 at 6:05 am

    If you're looking for a way to boost your cardio fitness and build lower body strength, the best exercise bikes are a great option. You can choose between stationary (low-intensity) and spin (high ...

  • Exercise is good for health — but why? A study in rats offers insight
    on April 30, 2024 at 5:00 pm

    It’s widely known that exercise is beneficial for health. Yet science doesn’t have a clear understanding of what makes moving so good for us, including what molecular mechanisms are activated ...

  • Exercise Helps Your Brain as Much as Your Body
    on April 30, 2024 at 5:00 pm

    Let’s start thinking differently about exercise. Here’s how we know. Animal exercise studies typically run rats for weeks on running wheels. The animals gleefully run every night, sprinting ...

  • Should an Investor Hold or Exercise an Option?
    on April 29, 2024 at 5:00 pm

    Learn about our editorial policies When is it time to exercise an option contract? That's a question that investors sometimes struggle with because it's not always clear if it's the optimal time ...

  • Health Benefits Of Exercise (Other Than Weight Loss)
    on April 29, 2024 at 9:47 am

    Thank you for submitting your question. Keep reading Forbes Advisor for the chance to see the answer to your question in one of our upcoming stories. Our editors also may be in touch with follow ...

The Latest Google Headlines on:
Exercise mimetics

[google_news title=”” keyword=”exercise mimetics” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]

What's Your Reaction?
Don't Like it!
0
I Like it!
0
Scroll To Top