A new drug could aid in losing weight and keeping it off.
The drug, described in the journal Cell Metabolism on July 26, increases sensitivity to the hormone leptin, a natural appetite suppressant found in the body. Although so far the new drug has only been tested on mice, the findings have implications for the development of new treatments for obesity in humans.
“By sensitizing the body to naturally occurring leptin, the new drug could not only promote weight loss, but also help maintain it,” says senior study author George Kunos of the National Institute on Alcohol Abuse and Alcoholism. “This finding bodes well for the development of a new class of compounds for the treatment of obesity and its metabolic consequences.”
Although leptin is an appetite suppressant, leptin supplements alone have not been effective at reducing body weight in humans. It’s thought that this is because of desensitization to the hormone; leptin is still there, but our bodies can no longer respond to it. While it is not entirely clear how this desensitization occurs, cannabinoid receptors, which mediate the feelings of hunger produced by marijuana and naturally occurring cannabinoids in the body, are thought to be involved. So blocking these receptors, rather than providing excess leptin, could be more effective at long-term weight loss. Knowing that marijuana use causes the munchies, scientists had developed anti-obesity drugs that target cannabinoid receptor type 1 (CB1R). One CB1R-binding drug called rimonabant was sold in Europe beginning in 2006, but it was taken off the market a few years later due to serious psychiatric side effects, including anxiety, depression and thoughts of suicide.
via Science Daily
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