The results suggest the technique could be used to combat a variety of diseases.
Using a novel form of immune-genetic therapy, researchers from Yale School of Medicine and the Jagiellonian University College of Medicine in Poland have successfully inhibited a strong immune allergic inflammatory response in the skin of mice. The results suggest the technique could be used to combat a variety of diseases.
“We use an antibody coating we chose to deliver therapeutic genetic material we selected to target cells,” said Dr. Philip Askenase, professor of medicine and senior author of the study published July8 in the Journal of Allergy and Clinical Immunology.
The delivery system consists of naturally occurring nanoparticles called exosomes that are about one thousandth the size of donor cells that release them. These tiny vesicles were once thought to contain only unneeded cellular debris. However, in the last decade, scientists have shown that there are billions of exosomes in the circulation and that they carry genetic instructions in the form of micro-RNAs (miRNA) to regulate the functions of nearby and distant cells.
Askenase and colleagues found that exosomes could be coated with an antibody of their choosing. These nanovesicles were able to deliver therapeutic miRNA to specific cells targeted by the antibody. In the current study, the coated exosomes delivered their miRNA cargo to immune system cells, inhibiting an active allergic disease response in the skin of mice.
“These natural nanoparticles are present throughout the body,” said Dr. Krzysztof Bryniarski of Jagiellonian University and lead author of the paper. “They seem to be a superior delivery system compared to artificial nanoparticles currently in use, which often are eliminated from the body because they are sensed as artificial.”
The Latest Bing News on:
Nature’s own nanoparticles
- How natural nanomotors could propel new drug delivery systemson February 13, 2025 at 1:30 am
Delivering drugs to specific, hard-to-reach areas in the human body remains a challenge in drug development. Typically, drug molecules administered via pills or injections circulate randomly through ...
- Nanoparticles demonstrate new and unexpected mechanism of coronavirus disinfectionon February 11, 2025 at 8:15 am
Titania nanoparticles damage enveloped viruses by directly binding with membrane phospholipids – a previously unknown mode of antiviral action ...
- Breakthrough Discovery: Nanoparticles That Neutralize Viruses in the Darkon February 5, 2025 at 6:21 am
Scientists have identified nanoparticles that latch onto and destroy virus membranes, opening new possibilities for antiviral coatings and air filters. This method could provide constant, passive ...
- Printable molecule-selective nanoparticles enable mass production of wearable biosensorson February 3, 2025 at 8:13 pm
Researchers have developed a way to print nanoparticles like ink, creating inexpensive sweat sensors that can continuously monitor multiple molecules.
- Nature-inspired nanotechnology acts as body's own courier service for genetic medicineson February 3, 2025 at 8:49 am
A large research team led by nanotechnologist Roy van der Meel rebuilt the body's own proteins and fats into nano-delivery vans that get genetic medicines to exactly the right place in the body. In a ...
- Plastic antibodieson January 13, 2025 at 9:31 pm
However, nature's own antibodies are not always perfect for ... Figure 2: Biodistribution of melittin and MIP nanoparticles. The question remains: has a new era in molecular imprinting technology ...
- Nature and uses of nanoparticles - Edexcelon October 26, 2023 at 4:18 am
A zinc oxide nanoparticle has a diameter of 32 nm. The diameter of a zinc atom is 0.28 nm. Estimate how many times larger the nanoparticle is compared to a zinc atom. A cube-shaped nanoparticle ...
- Nature’s Lipid Nanoparticles: Exosomes in Drug Delivery and Therapeuticson February 28, 2023 at 5:55 pm
Their distinctive properties such as innate stability, low immunogenicity, biocompatibility, and excellent tissue or cell penetration capabilities allow them to function as superior natural ...
The Latest Google Headlines on:
Nature’s own nanoparticles
[google_news title=”” keyword=”Nature’s own nanoparticles” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
The Latest Bing News on:
Immune-genetic therapy
- Study reveals immune system's crucial role in amyotrophic lateral sclerosis at cellular levelon February 13, 2025 at 6:29 am
A team of researchers from the Sant Pau Research Institute (IR Sant Pau) has published a study in the Journal of Neuroinflammation that, for the first time, examines in depth the role of the ...
- Gene Therapy: Revolutionizing Medicine By Tackling Diseases At Their Genetic Rootson February 13, 2025 at 3:29 am
Gene therapy represents a paradigm shift in modern medicine, offering unprecedented opportunities to combat diseases at their genetic origin.
- Older women may face higher risk from gene therapy for eye diseaseson February 12, 2025 at 3:27 pm
Unlike older male eye cells, which showed a consistent immune response pattern, older female eye cells appeared to experience more stress and a heightened inflammatory reaction. This suggests that ...
- One shot to lower cholesterol for life? Scientists unlock a groundbreaking gene therapyon February 11, 2025 at 3:36 pm
Researchers developed an epigenetic editing approach to silence the PCSK9 gene, achieving long-term cholesterol reduction without altering DNA, offering a potential one-time treatment for high ...
- Reprogramming compromised immune cells to fight canceron February 11, 2025 at 12:39 pm
Northwestern Medicine investigators have developed a new avenue to reprogram compromised immune cells to act against tumors, according to a study published in Science Advances.
- Scientists Discover Bat Gene That Could Revolutionize COVID-19 Treatmenton February 10, 2025 at 10:03 pm
A study on bat genomes, involving Texas Tech University, discovered genetic adaptations that help bats resist viral infections, including COVID-19. Researchers found that a bat gene, ISG15, can reduce ...
- New research uncovers hidden rules of immune response, opening doors for better vaccines and immunotherapieson February 10, 2025 at 9:38 am
Scientists at the Institute for Systems Biology (ISB) have uncovered key insights into how T cells—the body's frontline immune soldiers—respond to infections like COVID-19. Their research suggests ...
- Older women face higher risks with new gene therapies for eye diseases, study findson February 10, 2025 at 8:59 am
Older women could be vulnerable to harmful inflammation from new gene therapies to treat incurable eye diseases, new research has found. The University of Bristol-led study, published in Molecular ...
- Age, Gender Affect New Eye Gene Therapy Efficacy: Studyon February 10, 2025 at 2:22 am
Older women could be vulnerable to harmful inflammation from new gene therapies to treat incurable eye diseases, new research has found. The ...
- Rethinking Trauma Therapy: The Key Role of the Immune Systemon February 9, 2025 at 9:20 am
Discover how psychoneuroimmunology transforms trauma therapy by addressing the immune system's role in health, regulation, and developmental and complex trauma integration.
The Latest Google Headlines on:
Immune-genetic therapy
[google_news title=”” keyword=”immune-genetic therapy” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
