A natural, nontoxic product called genistein-combined polysaccharide, or GCP, which is commercially available in health stores, could help lengthen the life expectancy of certain prostate cancer patients, UC Davis researchers have found.
Men with prostate cancer that has spread to other parts of the body, known as metastatic cancer, and who have had their testosterone lowered with drug therapy are most likely to benefit. The study, recently published in Endocrine-Related Cancer, was conducted in prostate cancer cells and in mice.
Lowering of testosterone, also known as androgen-deprivation therapy, has long been the standard of care for patients with metastatic prostate cancer, but life expectancies vary widely for those who undergo this treatment. Testosterone is an androgen, the generic term for any compound that stimulates or controls development and maintenance of male characteristics by binding to androgen receptors.
The current findings hold promise for GCP therapy as a way to extend life expectancy of patients with low response to androgen-deprivation therapy.
Paramita Ghosh, an associate professor in the UC Davis School of Medicine, led the pre-clinical study with a team that included UC Davis Comprehensive Cancer Center Director Ralph de Vere White, a UC Davis distinguished professor of urology. Ruth Vinall in the UC Davis Department of Urology and Clifford Tepper in the UC Davis Department of Biochemistry and Molecular Medicine directed the studies in mice; Ghosh’s laboratory conducted the cell studies.
The research focused on GCP, a proprietary extract cultured from soybeans and shiitake mushrooms and marketed by Amino-Up of Sapporo, Japan. Researchers found that the combination of the compounds genistein and daidzein, both present in GCP, helps block a key mechanism used by prostate cancer cells to survive in the face of testosterone deprivation.
The research team had earlier shown that when a patient’s androgen level goes down, cancerous prostate cells kick out a protein known as filamin A, which is otherwise attached to the androgen receptor in the cell’s nucleus. The androgen receptor regulates growth of prostate cancer cells. Once filamin A leaves the cancerous cell’s nucleus, that cell no longer requires androgens to survive. Thus, loss of filamin A allows these cells to survive androgen deprivation, at and the cancer essentially becomes incurable.
The paper, titled “Enhancing the effectiveness of androgen deprivation in prostate cancer by inducing Filamin A nuclear localization,” shows for the first time that GCP keeps filamin A in the nucleus. As long as this protein remains attached to the androgen receptor, the cancerous cells need androgens to survive and grow. They die off when starved of androgens, thus prolonging the effects of androgen deprivation, which ultimately prolongs the patient’s life.
The team’s hypothesis is that metastatic prostate cancer patients with the weakest response to androgen-deprivation therapy could be given GCP concurrently with androgen deprivation therapy to retain Filamin A in the nucleus, thereby allowing cancer cells to die off.
The Latest Bing News on:
Prostate cancer
- Remembering Late Husband, Nurse Implores MPs To Fund Early Detection Of Prostate Canceron May 8, 2024 at 2:20 pm
Unlike, breast, bowel and cervical cancer, there’s no population-based programme for contacting, assessing and diagnosing New Zealand men whose risk can first be measured through a simple PSA blood ...
- NEWS CENTER Maine anchor Lee Goldberg marks milestone in prostate cancer journey with PSA about PSAson May 8, 2024 at 9:25 am
NEWS CENTER Maine's Morning Report anchor Lee Goldberg is reminding everyone with a prostate to get regular PSA tests.
- “Here’s How I Knew I Had Prostate Cancer”: One Patient’s Story of Abruptly Elevated Markerson May 8, 2024 at 8:42 am
The prostate is a small gland located in the male reproductive system that's essential for producing seminal fluid. When it's healthy, the prostate is shaped similarly to a walnut, but prostate cancer ...
- HRR Testing Underused in Metastatic Castration-Resistant Prostate Canceron May 8, 2024 at 7:59 am
HRR testing is underused in patients with metastatic castration-resistant prostate cancer, a large study suggests.
- Prostate cancer breakthrough means men could avoid chemotherapyon May 8, 2024 at 4:39 am
Thousands of men a year with advanced prostate cancer could avoid gruelling chemotherapy by combining radiotherapy and hormone therapy, a study reveals. Targeting the radiotherapy to the sites where ...
- Lack of Clinical Trial Availability Tied to Worse Prostate Cancer Mortalityon May 6, 2024 at 8:57 am
Of note, the most vulnerable counties had a lower prostate cancer incidence rate (mean 393.8 vs 411.7 per 100,000 people, P
- What is the association between post-diagnostic plant-based dietary patterns and the risk of prostate cancer progression?on May 6, 2024 at 6:13 am
The study aimed to investigate the impact of post-diagnosis consumption of plant-based food items on clinical outcomes in prostate cancer patients, focusing on two diet indices: an overall plant-based ...
- O.J. Simpson died from prostate cancer, not COVID-19 vaccine | Fact checkon May 3, 2024 at 9:51 am
There is no evidence Simpson's death was in any way related to the COVID-19 vaccine. His family released a statement that indicates he died of cancer.
- Ketone supplement may boost immunotherapy against prostate canceron May 2, 2024 at 9:00 am
Researchers have found that adding a pre-ketone supplement to immunotherapy boosted its effectiveness against prostate cancer in mouse models.
- Prostate cancer survivor sheds light on common stigmason May 1, 2024 at 6:01 am
“Because symptoms often don't appear before the cancer is at a more advanced stage, we need to be much louder about prostate cancer awareness and utilizing early detection as the first line of defense ...
The Latest Google Headlines on:
Prostate cancer
[google_news title=”” keyword=”prostate cancer” num_posts=”10″ blurb_length=”0″ show_thumb=”left”] [/vc_column_text]The Latest Bing News on:
Genistein-combined polysaccharide
- Novel Oral Synthetic Genistein Nanosuspension May Protect Against Negative Effects Of Radiation Therapy In Lung Canceron April 20, 2024 at 8:12 am
BIO 300 use led to reduced levels of a proinflammatory/profibrotic cytokine associated with lung injury from radiation therapy. BIO 300 did not interfere with the pharmacokinetics of chemotherapy, did ...
- Which colleges put together the best football and basketball seasons combined?on April 16, 2024 at 10:59 pm
In this edition of Sensational Sports Sevens, we rank the major college sports programs that produced the best combined football and basketball results this year. An interesting note is that only ...
- Recent advances in application of polysaccharides in cosmeticson April 9, 2024 at 5:00 pm
With the increasing application of natural ingredients in the cosmetics industry, the beneficial properties of natural polysaccharides have been effectively harnessed. Certain polysaccharides ...
- Powerball and Mega Millions jackpots now at a combined $1.9 billionon March 24, 2024 at 9:51 am
Be sure to get your tickets! The Powerball and Mega Millions Powerball jackpots are now at a combined $1.9 billion. The lottery prizes swelled after no tickets matched all six numbers in drawings ...
- Elon Musk predicts AI will likely be smarter than 'all humans combined' by 2029on March 13, 2024 at 12:20 pm
"By 2029, AI is probably smarter than all humans combined." READ ON THE FOX BUSINESS APP Musk has been outspoken about his concerns regarding AI and the dangers associated with it, often calling ...
- Combined Degree Programson March 14, 2023 at 6:58 pm
The combined bachelor's - master's degree program allows highly qualified students to simultaneously pursue a baccalaureate and master's degree. Students considering the combined option should seek ...
- Hybrid Life Insurance and Long Term Care (2024)on March 16, 2021 at 12:41 pm
Drew Gurley is a licensed life insurance expert with nearly 15 years of experience. During his career as both a licensed life insurance agent and industry executive, he has helped thousands of ...
- Combined Degree Programon September 26, 2020 at 11:20 pm
Students in a combined program will remain as undergraduates until they apply for graduation or submit a request to the Graduate School to have their classification changed from undergraduate to ...
- Combined Science - Edexcelon August 14, 2020 at 11:46 pm
Find your added subjects in My Bitesize. Free online Edexcel foundation/higher science tests based on past papers to increase your understanding of biology, chemistry and physics GCSE exams.
- Genistein improves BMD in osteopenic postmenopausal womenon June 16, 2020 at 3:57 pm
Genistein is a component of soya that is similar to 17β-estradiol, and might have protective effects against bone loss according to a number of small, short-term studies. Because of its ...
The Latest Google Headlines on:
Genistein-combined polysaccharide
[google_news title=”” keyword=”genistein-combined polysaccharide” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]