via Arizona Transplant Associates
Regenerative medicine researchers at Wake Forest Baptist Medical Center have addressed a major challenge in the quest to build replacement kidneys in the lab.
Working with human-sized pig kidneys, the scientists developed the most successful method to date to keep blood vessels in the new organs open and flowing with blood. The work is reported in journal Technology.
“Until now, lab-built kidneys have been rodent-sized and have functioned for only one or two hours after transplantation because blood clots developed,” said Anthony Atala, M.D., director and professor at the Wake Forest Institute for Regenerative Medicine and a senior author on the study. “In our proof-of-concept study, the vessels in a human-sized pig kidney remained open during a four-hour testing period. We are now conducting a longer-term study to determine how long flow can be maintained.”
If proven successful, the new method to more effectively coat the vessels with cells (endothelial) that keep blood flowing smoothly, could potentially be applied to other complex organs that scientists are working to engineer, including the liver and pancreas.
The current research is part of a long-term project to use pig kidneys to make support structures known as “scaffolds” that could potentially be used to build replacement kidneys for human patients with end-stage renal disease. Scientists first remove all animal cells from the organ – leaving only the organ structure or “skeleton.” A patient’s own cells would then be placed in the scaffold, making an organ that the patient theoretically would not reject.
The Latest on: Replacement kidneys
[google_news title=”” keyword=”Replacement kidneys” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Replacement kidneys
- Organ shortage: Surgeons are saving human lives with pig kidneyson April 26, 2024 at 9:29 pm
Surgeons at NYU Langone Health renowned academic medical center lin New York, have performed the world's first combined heart pump and gene-edited pig kidney transplant on a woman with end-stage ...
- Muslim human rights activist in need of kidney finds help from Jewish communityon April 26, 2024 at 2:51 pm
She's been helping the Jewish community and the Muslim community with the Council of Muslims against antisemitism and it's our turn to help her.' ...
- What dog owners should know about leptospirosison April 26, 2024 at 9:28 am
Emmanuelle Butty, med.vet., DACVIM (SAIM), assistant clinical professor at Cummings School of Veterinary Medicine, sometimes treats dogs with leptospirosis, an infection that can lead to kidney ...
- The National Kidney Foundation Urges Passage of New Home Dialysis Billon April 23, 2024 at 4:10 am
The National Kidney Foundation is applauding a move by Congress to increase access to care and improve outcomes for some patients on dialysis. The Improving Access to Home Dialysis Act (HR-8075) was ...
- Global Chronic Kidney Disease Burden Is Growingon April 22, 2024 at 4:59 pm
CKD-related emergency department visits and hospitalizations will rise by 17% to 58%. The carbon footprint from renal replacement therapy is anticipated to increase from approximately 14 to 25 billion ...
- Prevention still best medicine for kidney diseaseon April 20, 2024 at 6:30 pm
This well-presented story from facts shared of stage-5 kidney disease needs to be enhanced ... to fail and after the body factory is closed, replacement parts are few and far between.
- Opting For Keratin Hair Treatment? Experts Explain How It May Lead To Kidney Damageon April 18, 2024 at 11:10 pm
The use of these hair-straightening products containing glyoxylic acid is associated with a risk for acute kidney failure. This is because the glycolic acid is converted to oxalate, which deposits in ...
- Understanding The Rising Surge Of Kidney Disease In Indiaon April 17, 2024 at 3:17 am
Addressing chronic kidney disease (CKD) in India demands a comprehensive strategy, considering that over 17% of the population is affected.
- Nate Robinson Urgently Seeks Kidney Replacement: ‘I Don’t Have Long’ | Videoon April 16, 2024 at 12:00 pm
Nate Robinson says he doesn’t have long to live if he can't get a kidney replacement following a diagnosis of renal kidney failure.
- Former Basketball Player Says He Doesn’t Have Long to Live with Organ Donationon April 15, 2024 at 9:21 am
Former NBA player Nate Robinson says he doesn't have long to live with without a transplant for his kidney disease. He's been ...
via Bing News
