via Swanson School of Engineering
For years, scientists speculated that the heart’s helical arrangements and complex musculature pumps blood more efficiently throughout the body. Though thanks to the difficulty in reproducing such complex and intricate details in artificial hearts, researching this phenomenon proved difficult.
However, in a new study published in Science, a team of researchers from multiple institutions have come together to utilize a new, more advanced method to fabricate artificial tissues and organs. This team included Qihan Liu, an assistant professor in the University of Pittsburgh Swanson School of Engineering.
“It is a huge manufacturing challenge to make material that mimics biological tissue,” Liu said. “Biological tissues consist of various micro/nanofibers of complex spatially varying alignment. The arrangement of these fibers is how nature program the rich mechanical behavior of biological tissue. However, currently there is no manufacturing tool that can capture this complex arrangement. While common 3D printing methods can easily realize complex fiber arrangements, 3D printing cannot print nanofibers at a throughput relevant to tissue engineering. While established nanofiber spinning techniques such as electrospinning can produce nanofibers at mass-production-level high throughput, complex fiber arrangement has yet to be realized.”
The researchers thus proposed the process of focused rotary jet spinning. FRJS is an additive manufacturing method which uses centrifugal spinning to rapidly form fibers. The fibers are subsequently focused, aligned, and deposited onto targeted locations with a controlled airstream. By using airflow, this method allows thousands of micro/nanofibers to be simultaneously manipulated, which ensures high throughput. With the specially designed airflow, FRJS can manufacture 3D fiber constructs that are much more complex than current methods can create.
The researchers compare their methods to two other ways of producing artificial organs and tissue: 3D printing and fiber spinning. Although 3D printing continues to contribute major advancements to the development of artificial organs and tissue, the researchers counter that 3D printing takes too long to achieve the detail and complexity FRJS can offer.
Another currently used method is fiber spinning, which allows for a faster production but not as much detail or complexity as FRJS. Thus, the researchers present FRJS as a method to make more complex creations in a timelier manner.
To display the possibilities of FRJS in this context, the researchers used the process to create samples, including a full-scale fiber human heart model to show the capability of manufacture complex 3D structure, a three layer dual-chamber ventricle model to show the capability to capture complex fiber alignment in biological tissues and single-layer ventricles with the size of a rat, cat, human and the 12,000-pound minke whale to show the scalability of the manufacturing process. The researchers also demonstrate how models like these created by FRJS can be used to understand the function of the helical cell arrangements within the heart.
These samples, however, are just one display of what can be done with FRJS.
“This paper is just one demonstration of what can be done with this method, really,” Liu said. “The sky is the limit.”
In the future, Liu said, FRJS could be used to recreate blood vessels, cartilage and other fiber-reinforced tissues. That would offer countless possibilities in mimicking biological tissues in robotics, engineering and more. Fiber-reinforced composite made with FRJS could even be utilized to build cars and airplanes with lighter fiber-reinforced materials that use optimized fiber arrangements to better handle the load.
Original Article: Study: Making an artificial heart fit for a human — with focused rotary jet spinning, not 3D
More from: Swanson School of Engineering
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
Focused rotary jet spinning
- Gaming News
In which we obsess over switch types, mounting styles, keycap profiles, stabs and rotary knobs. Here's everything you need to know before buying a mechanical keyboard, plus the best mechanical ...
- The best pressure washers in 2024
In fact, the blast from the rotary nozzle proved impressively ... so that you can change from a wider spray to a focused, rotating jet within seconds. Connect the app, and you can tell the K5 ...
- Medical Hacks
Despite recent advances in diagnosing cancer, many cases are still diagnosed using biopsies and analyzing thin slices of tissue underneath a microscope. Properly analyzing these tissue sample ...
- Kärcher K5 Power Control review: The deep clean machine
The second spray lance – the well-named Dirt Blaster – delivers a fierce, tightly focused rotary pattern that ... also get the T5 Surface Cleaner: a rotating brush that scrubs as it sprays ...
- Outdoors-focused Jet Hospitality acquires Wyoming hotels
The Park Motel will rebrand as a Jet Motor Inn, which Jet Hospitality ... lodging located near national parks and other nature-focused U.S. destinations.
Go deeper with Google Headlines on:
Focused rotary jet spinning
[google_news title=”” keyword=”focused rotary jet spinning” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]
Go deeper with Bing News on:
Fabricating artificial tissues and organs
- CRMC receives award for organ, tissue donation efforts
Capital Region Medical Center recently received recognition for a high number of organ and tissue donations. The Jefferson City-based hospital won this year's Excellence in Organ and Tissue Donation ...
- Novel fabrication method creates aligned nanofiber hydrogels for tissue regeneration
A team of chemists and bioengineers at Rice University and the University of Houston have achieved a significant milestone in their work to create a biomaterial that can be used to grow biological ...
- Research team develop porous sponge material for enhancing kidney hemostasis and repair
A POSTECH research team have crafted a material aimed at swiftly staunching kidney bleeding and facilitating wound recovery. Their research featured in the online edition of Biomaterials.
- The solution to kidney bleeding and recovery lies within a hemostasis sponge, using the inherent capabilities of the kidneys
POSTECH and Daegu Haany University collaborate on material development aimed at enhancing kidney hemostasis and repair, utilizing a kidney-derived substrate.
- Organ & Tissue Donation in Minority Communities
You got it. Denise, as we put up the website for the New Jersey Sharing Network, our longtime partners in this public awareness effort around organ and tissue donation, describe what the serious ...
Go deeper with Google Headlines on:
Fabricating artificial tissues and organs
[google_news title=”” keyword=”fabricating artificial tissues and organs” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]