Scientists at The University of Nottingham have developed a new substance which could simplify the manufacture of cell therapy in the pioneering world of regenerative medicine.
Cell therapy is an exciting and rapidly developing area of medicine in which stem cells have the potential to repair human tissue and maintain organ function in chronic disease and age-related illnesses. But a major problem with translating current successful research into actual products and treatments is how to mass-produce such a complex living material.
There are two distinct phases in the production of stem cell products; proliferation (making enough cells to form large tissue) and differentiation (turning the basic stem cells into functional cells). The material environment required for these two phases are different and up to now a single substance that does both jobs has not been available.
Now a multi-disciplinary team of researchers at Nottingham has created a new stem cell micro-environment which they have found has allowed both the self-renewal of cells and then their evolution into cardiomyocyte (heart) cells. The material is a hydrogel containing two polymers – an alginate-rich environment which allows proliferation of cells with a simple chemical switch to render the environment collagen-rich when the cell population is large enough. This change triggers the next stage of cell growth when cells develop a specific purpose.
Major priority
Professor of Advanced Drug Delivery and Tissue Engineering, Kevin Shakesheff, said:
“Our new combination of hydrogels is a first. It allows dense tissue structures to be produced from human pluripotent stem cells (HPSC) in a single step process never achieved before. The discovery has important implications for the future of manufacturing in regenerative medicine. This field of healthcare is a major priority for the UK and we are seeing increasing investment in future manufacturing processes to ensure we are ready to deliver real treatments to patients when HPSC products and treatments go to trial and become standard.”
The Latest on: Stem cell manufacturing
[google_news title=”” keyword=”Stem cell manufacturing” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: MStem cell manufacturing
- Tesla's cheapest ever EV could be in danger as it pulls back from next-gen manufacturing planson May 2, 2024 at 4:30 am
Tesla could be backing away from its previously announced plans to update its innovative gigacasting manufacturing process, according to a new report – and that adds further doubt to the possibility ...
- Multiply Labs and Wilson Wolf Corporation Collaborate to Automate G-Rex® Bioreactor for Cell Therapy Manufacturingon May 2, 2024 at 2:00 am
G-Rex® closed system bioreactors simplify CGT manufacturing by providing cells with unlimited oxygen and nutrients on demand. Without the need for media or oxygen pumps, G-Rex® bioreactors function as ...
- Strong Buy Rating for Poseida Therapeutics Amidst Strategic Partnerships and Robust CAR-T Manufacturing Capabilitieson May 1, 2024 at 9:29 pm
The company’s robust manufacturing process, capable of producing a high yield of CAR-T cells per batch, ensures a scalable and reliable supply for clinical and future commercial needs. The consistent ...
- New water circulation tech promises lower PERC solar cell manufacturing costson May 1, 2024 at 5:00 pm
A German team developed models to illustrate water-saving potential in PERC silicon solar cell manufacturing based on a circular ... achieve a net environmental improvement for the solar cells ...
- Standardized Viral Vector Manufacturingon May 1, 2024 at 1:00 pm
AAV and LVV cover the entire vector manufacturing process, from transfection to purification, as well as suspension and adherent processes.
- Leclanché Enhances Value Proposition with New PFAS-Free and Niobium Oxide Cells, Enters Testing Phase with Key Partnerson May 1, 2024 at 12:07 pm
With many suppliers in the battery industry set to be heavily affected by the plans, Leclanché SA (SIX: LECN), which has been using a water-based binder process in its cell production for over 13 ...
- Cell Therapy Manufacturing: Time to Move Faston April 30, 2024 at 9:54 am
The more quickly manufacturing and release obstructions can be cleared, the sooner lifesaving treatments can be administered.
- Ultium Cells plants 300 trees for Earth Day as buffer around Spring Hill facilityon April 30, 2024 at 5:52 am
Ultium Cells, their trade partners, and children from the Boys and Girls Club planted trees around the plant's periphery.
- Planned solar panel manufacturing plant to employ over 900 in eastern NCon April 26, 2024 at 4:11 pm
Vietnam-based Boviet Solar is set to use Greenville, North Carolina, as the site of its first solar panel manufacturing plant in North America ...
- Researchers create artificial cells that act like living cellson April 23, 2024 at 9:51 am
In a new study published in Nature Chemistry, UNC-Chapel Hill researcher Ronit Freeman and her colleagues describe the steps they took to manipulate DNA and proteins—essential building blocks of ...
via Bing News