Is there a real replacement for exercise?

via Michigan Medicine

Article Highlights

A protein called Sestrin might be responsible for many of the benefits of a good workout
Whether it be a brisk walk around the park or high intensity training at the gym, exercise does a body good. But what if you could harness the benefits of a good workout without ever moving a muscle? Michigan Medicine researchers studying a class of naturally occurring protein called Sestrin have found that it can mimic many of exercise’s effects in flies and mice. The findings could eventually help scientists combat muscle wasting due to aging and other causes
“Researchers have previously observed that Sestrin accumulates in muscle following exercise,”
When they overexpressed Sestrin in the muscles of normal flies, essentially maxing out their Sestrin levels, they found those flies had abilities above and beyond the trained flies, even without exercise. In fact, flies with overexpressed Sestrin didn’t develop more endurance when exercised
The beneficial effects of Sestrin include more than just improved endurance. Mice without Sestrin lacked the improved aerobic capacity, improved respiration and fat burning typically associated with exercise
“We propose that Sestrin can coordinate these biological activities by turning on or off different metabolic pathways,” says Lee. “This kind of combined effect is important for producing exercise’s effects.”
Could Sestrin supplements be on the horizon? Not quite, says Lee. “Sestrins are not small molecules, but we are working to find small molecule modulators of Sestrin.”
Additionally, adds Kim, scientists still don’t know how exercise produces Sestrin in the body. “This is very critical for future study and could lead to a treatment for people who cannot exercise.”

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University of Michigan | Pompeu Fabra University

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Is there a real replacement for exercise?

University of Michigan | Pompeu Fabra University

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