University of Guelph researchers have created a first-ever vaccine for gut bacteria common in autistic children.
The groundbreaking study by Brittany Pequegnat and Guelph chemistry professor Mario Monteiro appears this month in the journal Vaccine.
They developed a carbohydrate-based vaccine against the gut bug
Clostridium bolteae.
C. bolteae is known to play a role in gastrointestinal disorders, and it often shows up in higher numbers in the GI tracts of autistic children than in those of healthy kids.
More than 90 per cent of children with autism spectrum disorders suffer from chronic, severe gastrointestinal symptoms. Of those, about 75 per cent suffer from diarrhea, according to current literature.
“Little is known about the factors that predispose autistic children to C. bolteae,” said Monteiro. Although most infections are handled by some antibiotics, he said, a vaccine would improve current treatment.
“This is the first vaccine designed to control constipation and diarrhea potentially caused by C. bolteae and perhaps control autism-related symptoms associated with this microbe,” he said.
Autism cases have increased almost sixfold over the past 20 years, and scientists don’t know why. Although many experts point to environmental factors, others have focused on the human gut.
Some researchers believe toxins and/or metabolites produced by gut bacteria, including C. bolteae, may be associated with symptoms and severity of autism, especially regressive autism.
Pequegnat, a master’s student, and Monteiro used bacteria grown by Mike Toh, a Guelph microbiology PhD student.
The new anti- C. bolteae vaccine targets the specific complex polysaccharides, or carbohydrates, on the surface of the bug.
The vaccine effectively raised C. bolteae-specific antibodies in rabbits. Doctors could also use the vaccine-induced antibodies to quickly detect the bug in a clinical setting, said Monteiro.
The vaccine might take more than 10 years to work through preclinical and human trials, and it may take even longer before a drug is ready for market, Monteiro said.
The Latest Bing News on:
Autism spectrum disorders
- Fun ‘color run’ for autism awareness and a Vaca parkon April 27, 2024 at 11:21 pm
Hosted by the Neighborhood Boys and Girls Club, the Saturday morning event, which raised more than $2,000, benefitted Play 4 All Park in and other organizations serving youth ...
- Reflections on autism awareness monthon April 27, 2024 at 11:01 pm
Autism Spectrum Disorder (ASD) is a neurological and developmental disability … it is defined by differences in the brain, which affect how people communicate, interact, learn, and behave ...
- Study reveals how genetic changes in SCN2A gene impact autism and epilepsyon April 27, 2024 at 2:25 am
A genetic change or variant in a gene called SCN2A is a known cause of infantile seizures, autism spectrum disorder and intellectual disability, as well as a wide range of other moderate-to-profound ...
- This Philly fashion show features haute couture and the strengths of autismon April 27, 2024 at 2:00 am
Featured designers include O’Livis Couture, HerberTT Dash Haberdashery Boutique by James Vaughan, The Dress Matters Couture Bridal Boutique, Madiare K. Design, and Kyaura Amour Couture. Tickets start ...
- ‘Autism’ and the complex spectrum of possibilitieson April 26, 2024 at 7:47 pm
NASHVILLE, Tenn. (WSMV) - Autism diagnoses are much more common now than they were 25 years ago. The latest reports from the CDC show 1 in 36 children have been identified to have Autism Spectrum ...
- Shannon Sharpe under fire for ‘invalidating’ Amanda Seales’ experiences with autism, racismon April 26, 2024 at 3:50 pm
Shannon Sharpe hosted actor and comedian Amanda Seales on "Club Shay Shay.” The episode has now gone viral, with some criticizing Sharpe's interview tactics.
- Gene linked to epilepsy and autism decoded in new studyon April 26, 2024 at 11:04 am
A genetic change or variant in a gene called SCN2A is a known cause of infantile seizures, autism spectrum disorder, and intellectual disability, as well as a wide range of other moderate-to-profound ...
- Golisano Children's Hospital gains autism certification for improving compassion and careon April 26, 2024 at 9:00 am
They also welcomed a “sensory-friendly ambulance” for transporting children with autism that has unique features to minimize sounds, lights and other things that can trigger a sensory overload for ...
- Amanda Seales Felt “Interrogated” During ‘Club Shay Shay’ Interview, Clarifies Autism Spectrum Claimson April 26, 2024 at 8:21 am
Following Amanda Seales ’ viral Club Shay Shay interview with Shannon Sharpe, the cultural commentator has now voiced her disdain for how the sit-down was conducted. Seales took to Instagram a day ...
- Are parental psychiatric disorders related to the risk of autism spectrum disorder in the offspring?on April 26, 2024 at 4:31 am
The potential association between psychiatric disorders in parents and the risk of the offspring developing autism spectrum disorder.
The Latest Google Headlines on:
Autism spectrum disorders
[google_news title=”” keyword=”autism spectrum disorders” num_posts=”10″ blurb_length=”0″ show_thumb=”left”] [/vc_column_text]The Latest Bing News on:
Autism vaccine
- Anti-vaxxer campaigns spark worries as misinformation crisis riseson April 27, 2024 at 7:01 pm
They advance their theories by building on their conspiracies with misinformation and that is what makes the anti-vax stance dangerous to public health; it is anti-science and ...
- The importance of Autism Acceptance Monthon April 27, 2024 at 3:15 pm
The month of April has become a time of celebration for the neurodivergent community, particularly those with Autism Spectrum Disorder (ASD).
- A vaccine to combat antibiotic resistanceon April 27, 2024 at 2:00 pm
A team of researchers at Michigan State University have outlined an approach to combating a prevalent public health issue: the development of treatment-res | Technology ...
- Robert F. Kennedy Jr. draws 350 to West Seneca, says government is lying to youon April 27, 2024 at 11:20 am
He's controversial. He has a famous last name. His candidacy may determine who's the next U.S. president. And on Saturday, Robert F. Kennedy Jr. was at Kotecki's Grandview Grove in West Seneca to ...
- RFK Jr. repeats debunked vaccine claims in interview with Bill Maheron April 27, 2024 at 8:30 am
I’m not anti-vaccine,” the independent candidate told Maher. “I’m called that because it’s a way of silencing me.” ...
- Former anti-vaxxer addresses infectious disease conference in Normalon April 25, 2024 at 3:30 pm
Heather Simpson was the keynote speaker Wednesday at the Illinois Department of Public Health’s infectious disease conference at Illinois State University.
- ‘More than 10,000 children at risk of brain-swelling disease’ if MMR vaccine uptake ‘does not improve’ an expert warnson April 25, 2024 at 3:01 am
THOUSANDS of British children are at risk of contracting a fatal brain-swelling virus, an expert has warned. Dr Ava Easton of Encephalitis International said among the 3.4 million children in the ...
- Medical Professionals Look to Spread Awareness During Autism Acceptance Monthon April 24, 2024 at 3:32 pm
According to the CDC, one in 36 (2.8%) 8-year-old children have been identified with Autism Spectrum Disorder (ASD). Due to this, parents, educators, and health professionals want to make sure factual ...
- Ottawa injects another $36.4-million into vaccine injury compensation fundon April 24, 2024 at 1:33 pm
To date, a private firm called OXARO has received $56.2 million from Ottawa to run the program and pay out valid claims that originate outside of Quebec ...
- Bay Area Sutter Health offers vaccines in environment designed for patients with autismon April 23, 2024 at 7:40 pm
It is Autism Acceptance month and part of acceptance is advocating for equal opportunity. Managing the health care of children with autism can be challenging and stressful for parents. But Sutter ...
The Latest Google Headlines on:
Autism vaccine
[google_news title=”” keyword=”autism vaccine” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]