Diagnostic kits for personalized medicine – predicting resistance to chemotherapy treatments

Doctoral student and Kaye Innovation Award winner Ido Sagi at the Hebrew University of Jerusalem (Credit: Hebrew University)
Potential for regenerative medicine and cancer research earns doctoral student Ido Sagi a Kaye Innovation Award

Stem cell research holds huge potential for medicine and human health. In particular, human embryonic stem cells (ESCs), with their ability to turn into any cell in the human body, are essential to the future prevention and treatment of disease.

One set or two? Diploid versus haploid cells

Most of the cells in our body are diploid, which means they carry two sets of chromosomes — one from each parent. Until now, scientists have only succeeded in creating haploid embryonic stem cells — which contain a single set of chromosomes — in non-human mammals such as mice, rats and monkeys. However, scientists have long sought to isolate and replicate these haploid ESCs in humans, which would allow them to work with one set of human chromosomes as opposed to a mixture from both parents.

This milestone was finally reached when Ido Sagi, working as a PhD student at the Hebrew University of Jerusalem’s Azrieli Center for Stem Cells and Genetic Research, led research that yielded the first successful isolation and maintenance of haploid embryonic stem cells in humans. Unlike in mice, these haploid stem cells were able to differentiate into many other cell types, such as brain, heart and pancreas, while retaining a single set of chromosomes.

With Prof. Nissim Benvenisty, Director of the Azrieli Center, Sagi showed that this new human stem cell type will play an important role in human genetic and medical research. It will aid our understanding of human development – for example, why we reproduce sexually instead of from a single parent. It will make genetic screening easier and more precise, by allowing the examination of single sets of chromosomes. And it is already enabling the study of resistance to chemotherapy drugs, with implications for cancer therapy.

Diagnostic kits for personalized medicine

See Also

Based on this research, Yissum, the Technology Transfer arm of the Hebrew University, launched the company New Stem, which is developing a diagnostic kit for predicting resistance to chemotherapy treatments. By amassing a broad library of human pluripotent stem cells with different mutations and genetic makeups, NewStem plans to develop diagnostic kits for personalized medication and future therapeutic and reproductive products.

Learn more: First ‘haploid’ human stem cells could change the face of medical research; earn Kaye Innovation Award

The Latest on: Haploid embryonic stem cells
[google_news title=”” keyword=”haploid embryonic stem cells” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
  • Stem cells provide new insight into genetic pathway of childhood cancer
    on May 15, 2024 at 12:46 pm

    Scientists have discovered a new insight into the genetic pathway of childhood cancer, offering new hope for tailored treatments.

  • Fetal cells can be traced back to the first day of embryonic development
    on May 14, 2024 at 7:55 am

    Though more than 8 million babies have been born through in vitro fertilization (IVF), 70% of IVF implantations fail. As IVF is becoming a more common route to pregnancy in cases of infertility, there ...

  • Embryonic stem cells articles from across Nature Portfolio
    on May 10, 2024 at 5:00 pm

    Embryonic stem cells are pluripotent cells isolated from the inner cell mass of a blastocyst, the early mammalian embryo that implants into the uterus. Embryonic stem cells self-renew by dividing ...

  • Stem cells: A new mechanical transducer
    on May 10, 2024 at 11:08 am

    Scientists reveal how ETV4 controls stem cell differentiation in response to mechanical cues.

  • New stem cell research may have implications for liver transplantation
    on May 9, 2024 at 9:20 am

    Liver disease, due to viral infections, alcohol abuse, obesity, or cancer, accounts for one in every 25 deaths worldwide. A liver transplant can be life saving for people with end-stage liver disease.

  • Stem Cells: A Plenary Policy Forum
    on April 20, 2024 at 5:00 pm

    Blastocysts express 100% of these 11 genes when they are derived from ESCs, but only 62% of them when derived from cumulus cells. Thus, ESCs express all embryonic genes and do not require ...

  • Stem Cells in Reproductive Medicine
    on March 6, 2024 at 2:27 pm

    trophoblasts and endometrium from human embryonic and adult stem cells. Although focussing mainly on the practical elements of the use of stem cells in reproductive medicine, the book also contains a ...

  • The Stem Cell Divide
    on September 14, 2023 at 5:53 am

    Advocates counter that adult stem cells, useful as they may be for some diseases, have thus far proved incapable of producing the full range of cell types that embryonic stem cells can.

  • Embryonic stem cells
    on October 11, 2022 at 3:49 am

    Embryonic stem cells (ESCs or ES cells) are cells from the early embryonic development, from which all cells and organs of an individual descend. Embryonic stem cells are pluripotent, meaning that ...

  • Guidelines for Human Embryonic Stem Cell Research
    on March 28, 2020 at 8:00 am

    In 2005, the National Academies released the book, Guidelines for Human Embryonic Stem Cell Research, which offered a common set of ethical standards for a field that, due to the absence of ...

via Google News and Bing News

What's Your Reaction?
Don't Like it!
0
I Like it!
0
Scroll To Top