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Buck Institute for Research on Aging

July 30, 2019

The Buck Institute for Research on Aging  is the United States’ first independent biomedical research institute devoted solely to research on aging and age-related disease.

Could illness and mortality be predicted by your immune system “clock”

Could illness and mortality be predicted by your immune system “clock”

Extending lifespan by 500 percent – in worms

Extending lifespan by 500 percent – in worms

Update: Parabiosis is one of the hottest topics in age research

Older mice who are surgically joined with young mice in order to share a common bloodstream get stronger and healthier, making parabiosis one of the hottest topics in age research. Publishing in Nature Metabolism, researchers from the Buck Institute report that MANF (mesencephalic astrocyte-derived neurotrophic factor) is one of the factors responsible for rejuvenating the transfused older

Update: Parabiosis is one of the hottest topics in age research

Removal of aging cells contributes significantly in delaying the onset of age-related pathologies

A new study, affiliated with UNIST confirms that targeting SnCs could treat age-related degenerative joint disease. A recent study, led by an international team of researchers confirms that targeted removal of senescent cells (SnCs), accumulated in many vertebrate tissues as we age, contribute significantly in delaying the onset of age-related pathologies. This breakthrough research has been led

Removal of aging cells contributes significantly in delaying the onset of age-related pathologies

Stem cells restore long-term vision in mice using regenerative vision therapy

via Glaucoma Research Foundation Buck scientists restore long-term vision in blind mice, making a case for addressing the immune system’s role in rejecting transplanted cells Stem cell therapies hold great promise for restoring function in a variety of degenerative conditions, but one of the logistical hurdles is how to ensure the cells survive in the body

Stem cells restore long-term vision in mice using regenerative vision therapy

Mapping the Genes that Increase Lifespan

Following an exhaustive, ten-year effort, scientists at the Buck Institute for Research on Aging and the University of Washington have identified 238 genes that, when removed, increase the replicative lifespan of S. cerevisiae yeast cells. This is the first time 189 of these genes have been linked to aging. These results provide new genomic targets

Mapping the Genes that Increase Lifespan

Ibuprofen Use Leads to Extended Lifespan in Several Species, Study Shows

A common over-the-counter drug that tackles pain and fever may also hold keys to a longer, healthier life, according to a Texas A&M AgriLife Research scientist. Regular doses of ibuprofen extended the lifespan of multiple species, according to research published in the journal Public Library of Science-Genetics. “We first used baker’s yeast, which is an

Ibuprofen Use Leads to Extended Lifespan in Several Species, Study Shows

Memory loss associated with Alzheimer’s reversed for first time

Small trial from UCLA and Buck Institute succeeds using systems approach to memory disorders Patient one had two years of progressive memory loss. She was considering quitting her job, which involved analyzing data and writing reports, she got disoriented driving, and mixed up the names of her pets. Patient two kept forgetting once familiar faces

Memory loss associated with Alzheimer’s reversed for first time

Altering Community of Gut Bacteria Promotes Health and Increases Lifespan

Our data suggest that we should be able to impact health span and life span quite strongly Scientists at the Buck Institute for Research on Aging have promoted health and increased lifespan in Drosophila by altering the symbiotic, or commensal, relationship between bacteria and the absorptive cells lining the intestine. The research, appearing in the January 16,

Altering Community of Gut Bacteria Promotes Health and Increases Lifespan

Lifespan-Extending Drug Given Late in Life Reverses Age-Related Heart Disease in Mice

Elderly mice suffering from age-related heart disease saw a significant improvement in cardiac function after being treated with the FDA-approved drug rapamycin for just three months. The research, led by a team of scientists at the Buck Institute for Research on Aging, shows how rapamycin impacts mammalian tissues, providing functional insights and possible benefits for

Lifespan-Extending Drug Given Late in Life Reverses Age-Related Heart Disease in Mice

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