Researchers said on Tuesday that a new type of asthma drug could be a potential game changer for patients with moderate to severe respiratory disease.
The injectable drug, known as dupilumad, slashed asthmatic episodes by 87 percent in a mid-stage trial of 104 patients. The team wrote about the latest trial’s results in the New England Journal of Medicine (NEJM).
“Asthma that is difficult to treat is increasingly recognized as comprising different phenotypes,” lead author Sally Wenzel, MD, director of the University of Pittsburgh Asthma Institute said. “With this study, we wanted to see whether dupilumab would reduce a surrogate index for asthma exacerbations when given with ICS and LABA and when those two therapies were withdrawn.”
Dupilumad is a fully human monoclonal antibody that thwarts activation of the Th2 immune response implicated in asthma by blocking two cytokines, interleukin-4 and interleukin-13. Researchers performed a 20-week study on patients who had received weekly injections of the drug.
Patients in the study received either dupilumad or a placebo twice a day. During the fourth week, patients were instructed to withdraw LABA, and between weeks six and nine they tapered off ICS. They found that dupilumad provided an 87 percent reduction in protocol defined asthma exacerbations. Moreover, they saw significant improvements for other relevant asthma outcomes like lung functions and morning peak expiatory flow.
The Latest Bing News on:
Asthma
- Doctors Answer Common Questions About Pollen And Asthma.on May 8, 2024 at 2:28 pm
This causes the airways to become narrow and constricted, leading to wheezing, coughing, and difficulty breathing. This article examines the mechanism of pollen-induced asthma and the ways in which it ...
- Study reveals role of iron in allergic asthma and points to potential new therapieson May 8, 2024 at 11:00 am
New USC research shows that iron serves as a gas pedal driving certain immune cells that cause inflammation in the lungs during an allergic asthma attack—and blocking or limiting iron may reduce the ...
- It's World Asthma Day: How many people live with the disease in SLO County?on May 7, 2024 at 8:14 pm
In San Luis Obispo County, many people live with asthma and the number continues to grow. On World Asthma Day, we dive into the important facts of the disease.
- Professional Faqs: How Do I Know If My Child's Asthma Is Controlled?on May 7, 2024 at 2:28 pm
Expert opinion from Gustavo Campos Doctor of Medicine · 9 years of experience · Brazil Asthma will be controlled if the child does not complain any breathing distress during day and night, there are ...
- New study links gas stoves to child asthma, lung cancer and deathon May 7, 2024 at 12:01 pm
A study led by Stanford researchers says nitrogen dioxide exposure from gas stoves could be responsible for an estimated 19,000 deaths per year.
- The 11 workers most at risk for developing asthma — did your job make the list?on May 7, 2024 at 6:47 am
A law firm that specializes in industrial disease cases is revealing the 11 types of employees it claims are at higher risk for asthma due to frequent exposure to irritants — including hairdressers, ...
- Children with asthma are victims of our climate crisison May 7, 2024 at 4:00 am
A rougher allergy season and the prevalence of wildfires will make the summer especially tough for people with asthma.
- Wood County Health Alert: Gas Stoves Linked to Asthma in Children and Early Deaths. Doctor Explainson May 6, 2024 at 4:59 pm
Skip to main content ...
- New Haven County Health Alert: Gas Stoves Linked to Asthma in Children and Early Deaths. Doctor Explainson May 6, 2024 at 4:59 pm
Know this: "This research continues to solidify what we already know--gas stoves can lead to increase asthma in young children and harm those who have lung disease. Gas stoves in our homes can ...
- Asthma Newson May 1, 2024 at 5:00 pm
May 3, 2024 — A new study of air pollution in U.S. homes reveals how much gas and propane stoves increase people's exposure to nitrogen dioxide, a pollutant linked to childhood asthma.
The Latest Google Headlines on:
Asthma
[google_news title=”” keyword=”asthma” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
The Latest Bing News on:
Asthma drug
- Professional Faqs: How Does Low Temperature Affect The Risk Of Infections For People With Asthma And What Precautions Should They Take?on May 9, 2024 at 1:56 am
Low temperature can increase the risk of infections in people with asthma. Low temperature causes broncho-constriction, leading to increased mucus production and difficulty in the expiration of ...
- Improved treatments and prevention strategies to combat high childhood asthma rateson May 8, 2024 at 9:42 pm
Asthma can be deadly, especially for children. Cipla South Africa is at the forefront of a collective effort to ensure that those in need receive the most effective treatment.Asthma is a respiratory ...
- Montelukast: UK regulator says asthma drug needs clearer warnings of side effectson May 8, 2024 at 11:27 am
The asthma drug montelukast (Singulair) will carry more prominent warnings in the UK to alert doctors and patients to its potentially serious behavioural and neuropsychiatric side effects. Previously ...
- Study reveals role of iron in allergic asthma and points to potential new therapieson May 8, 2024 at 11:00 am
New USC research shows that iron serves as a gas pedal driving certain immune cells that cause inflammation in the lungs during an allergic asthma attack—and blocking or limiting iron may reduce the ...
- ‘Life-changing’ medication for asthma patients now available in Sussexon May 8, 2024 at 6:44 am
A specialist type of asthma treatment, that helps reduce lung inflammation, asthma attacks and the reliance of steroids, is now available at the Royal Sussex County Hospital.
- Sumter County Health Alert: Gas Stoves Linked to Asthma in Children and Early Deaths. Doctor Explainson May 7, 2024 at 11:53 am
In this article, Dr. Adriana Davis, Family Medicine, shares her expert insights of the findings and provides Florida residents with evidence-based recommendations for protecting their health.Why This ...
- FTC disputes new slate of Orange Book patents for weight loss, diabetes, asthma, and COPD drugson May 7, 2024 at 9:04 am
The patents in this latest round of warning letters consist of device-directed patents for 20 different brand name drug/device combination products to treat diabetes, weight loss, asthma, and COPD. As ...
- Could better asthma inhalers help patients, and the planet too?on May 6, 2024 at 6:12 am
Some doctors are promoting propellant-free inhalers over puff inhalers that emit greenhouse gases. Climate change can exacerbate respiratory ills because of more fires, air pollution and allergens.
- Warning over asthma drug after 500 neuropsychiatric reactions reported in young childrenon May 4, 2024 at 6:30 pm
The Medicines and Healthcare products Regulatory Agency (MHRA) announced last week that more prominent warnings would be added to the information provided on boxes of the asthma drug montelukast ...
- Asthma Newson May 1, 2024 at 5:00 pm
possibly increasing your risk of developing asthma or other respiratory illnesses, a ... Drug Limits Dangerous Reactions to Allergy-Triggering Foods, Stanford Medicine-Led Study of Kids Finds Feb ...
The Latest Google Headlines on:
Asthma drug
[google_news title=”” keyword=”asthma drug” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
