via twitter.com
Computational modelling has been used to create dual-action compounds with exciting potential as new antibiotics.
The proof of principle experiment raises the possibility of new antibiotics that can target harmful bacteria on two fronts and consequently are less likely to be overcome by resistant strains.
The University of Leeds/John Innes Centre collaboration modelled potential new drugs based on the activity of thiophene compounds. These had previously shown promise as antibiotics before toxicity issues prevented them from going forward to human clinical trials.
Observing the activity of the thiophenes, the team computationally modelled new antibiotic candidates and then synthesised and tested them on pathogenic bacteria Escherichia coli (E. coli).
They found a series of biphenyl-based compounds inhibited the activity of the harmful bacteria by targeting two enzymes, DNA gyrase, and DNA topoisomerase IV, both of which are essential to bacterial survival.
“These novel compounds represent the start of a programme that could lead to a new series of antibiotics,” said Professor Tony Maxwell, of the John Innes Centre, and one of the authors of the study.
“The current programme represents a proof of principle, and this initial success suggests we will be able to discover even better antibiotic candidates going forward.” added first author of the study, University of Leeds researcher Dr Kyle Orritt. 23e o9
The researchers have already discussed the implications of the work with pharmaceutical companies, raising the possibility of a new source of antibiotics.
This work follows the discovery of a new possibility of exploiting the established antibacterial target DNA gyrase which offers a new medicinal chemistry strategy.
New antibiotics are urgently needed owing to the evolution of bacteria which are resistant to existing treatments. This problem of antimicrobial resistance (AMR) poses an enormous threat to human health due to an increase in the number of untreatable bacterial infections.
By 2050 it is predicted that AMR will be responsible for 10 million global deaths annually, more deaths than cancer and costing the world economy $100 trillion.
Original Article: Could cyber designs deliver potent dual-action antibiotics?
More from: University of Leeds | John Innes Centre
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
Dual-action antibiotics
- Insights into Antibiotic Resistance Through Metagenomic Approaches
Insert length between 800 and 3000 bp. ‡‡ One clone was resistant to all three antibiotic classes in a secondary screen. The generic term 'antibiotic' is used to denote any class of organic ...
- 8 UTI Home Remedies Other Than Antibiotics
While antibiotics are the most effective treatment for a UTI, you can use these home remedies to help manage your symptoms. Share on Pinterest A UTI can cause symptoms like bloody urine and pain ...
- OsteoRemedies® Obtains Expanded Indications for SPECTRUM® Dual Antibiotic Bone Cement
MEMPHIS, Tenn., April 23, 2024 /PRNewswire/ -- OsteoRemedies ® LLC, an orthopedic company focused on providing simple solutions to complex disorders, has announced FDA clearance for expanded ...
- Researchers uncover details of how bacteria build protective barriers, may inform new antibiotics
Yale researchers have uncovered new details on how bacteria like E. coli build their protective barriers, which will inform new antibiotic development.
- Understanding bacteria protection in order to break through it
Antibiotic-resistant bacteria are a growing problem when it ... Not only is it responsible for the degradation of LpxC, but it also inhibits the enzyme’s action before degradation happens. “Basically, ...
Go deeper with Google Headlines on:
Dual-action antibiotics
[google_news title=”” keyword=”dual-action antibiotics” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]
Go deeper with Bing News on:
Thiophene compounds
- Compound Interest Calculator
See how your savings and investment account balances can grow with the magic of compound interest. Many or all of the products featured here are from our partners who compensate us. This ...
- Best compound interest accounts
The best compound interest accounts perform the wonderful trick of earning money on your money. This is especially useful in today’s high-rate environment, and for anyone who tried to save over ...
- What Is the Link Between Mutual Funds and Compound Interest?
Many do. And what's more, they offer one of the easiest ways for investors to reap the benefits of compound interest. Keep reading to find out how you can earn income from your mutual fund ...
- Organic Chemistry News
May 6, 2024 — Why 3,000 bars are needed to take a comprehensive look at a protein: Researchers present a new high-pressure spectroscopy method to unravel the ...
- Compound Annual Growth Rate: What You Should Know
pixdeluxe / GettyImages Compound annual growth rate, or CAGR, is the mean annual growth rate of an investment over a specified period of time longer than one year. It represents one of the most ...
Go deeper with Google Headlines on:
Thiophene compounds
[google_news title=”” keyword=”thiophene compounds” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]