Human clinical trials scheduled
Scientists may have overcome a major roadblock in the development of Alzheimer’s therapies by creating a new technology to observe ? in the back of the eye ? progression of the disease before the onset of symptoms. Clinical trials are to start in July to test the technology in humans according to a paper recently published in Investigative Ophthalmology & Visual Science (IOVS).
The paper, titled Early detection of amyloidopathy in Alzheimer’s mice by hyperspectral endoscopy, builds upon previous work in cells by detecting changes in the retina of mice predisposed to develop Alzheimer’s.
Early detection of Alzheimer’s is critical for two reasons. “First, effective treatments need to be administered well before patients show actual neurological signs,” said author Robert Vince, PhD, of the Center for Drug Design at the University of Minnesota (UMN). “Second, since there are no available early detection techniques, drugs currently cannot be tested to determine if they are effective against early Alzheimer’s disease. An early diagnostic tool like ours could help the development of drugs as well.”
Looking through the eye to see the brain is a key advantage of the new technology. “The retina of the eye is not just ‘connected’ to the brain — it is part of the central nervous system,” said author Swati More, PhD, also of the Center for Drug Design at UMN. While the brain and retina undergo similar changes due to Alzheimer’s disease, “unlike the brain, the retina is easily accessible to us, making changes in the retina easier to observe.”
“We saw changes in the retinas of Alzheimer’s mice before the typical age at which neurological signs are observed,” said More. “The results are close to our best-case scenario for outcomes of this project.”
Learn more: Alzheimer’s Detected Before Symptoms via New Eye Technology
The Latest on: Alzheimer’s
[google_news title=”” keyword=”Alzheimer’s” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Alzheimer’s
- Annovis, Anavex, And Cassava Sciences: Trying To Box Oneself Out Of The Alzheimer's Boxon May 9, 2024 at 5:43 pm
Read here to learn why investing in Anavex, with its potential to stabilize cognitive impairment in Alzheimer's disease, is still a worthwhile choice.
- Alzheimer's disease: Understanding this degenerative mental disorderon May 9, 2024 at 4:59 pm
Additionally, two new drugs for Alzheimer's have displayed significant potential in slowing the progression of the disease during its initial phases. These medications target a substance called beta ...
- A gene long thought to just raise the risk for Alzheimer's may cause some caseson May 9, 2024 at 2:15 pm
More than 6 million Americans, and millions more worldwide, have Alzheimer’s. A handful of genes are known to cause rare “early-onset” forms, mutations passed through families that trigger symptoms ...
- Search Intensifies for Missing 84-Year-Old Man with Alzheimer's in La Porteon May 9, 2024 at 1:30 pm
George Richardson, 84, with Alzheimer's, is missing in La Porte, TX; last seen Tuesday; police and community search ongoing.
- Resources for Alzheimer's screening, treatment are woefully inadequate in Ohio | Opinionon May 9, 2024 at 6:10 am
A patient’s delay in a diagnosis is not their fault, but could be disqualifying them for available treatments.
- ‘I’m a Neurologist, and This Is the Type of Nut I Swear by for Alzheimer’s Prevention'on May 9, 2024 at 3:25 am
While it’s impossible to prevent Alzheimer’s through diet alone (it’s a complicated disease with many factors at play), you can lower your risk by eating a diet rich in brain-healthy foods—and that ...
- Getting Alzheimer’s treatment to those who need it poses particular challengeson May 9, 2024 at 1:31 am
Diagnosis, treatment, monitoring and access can pose problems for both patients and their doctors, experts said at a STAT virtual event Wednesday.
- Former FOX31 anchor raising awareness after Alzheimer’s claims her mother’s lifeon May 8, 2024 at 9:02 pm
She spent more than a decade at the FOX31 anchor desk, sharing the stories of Coloradans often struggling through difficult times. But Libby Weaver never expected the struggles her own family would ...
- Alzheimer’s Association calling for volunteerson May 8, 2024 at 5:00 pm
TOLEDO — The Alzheimer’s Association is calling for volunteers to join initiatives in Northwest Ohio. The chapter serves 24 counties, including Allen, Auglaize and Putnam, with community education, ...
- Research finds Alzheimer's may be passed down more than previously thoughton May 8, 2024 at 3:06 pm
BOSTON - Alzheimer's disease may be passed down in families more than previously thought.
via Bing News