A spray gel embedded with immune-boosting drugs could help lower the risk of cancer recurrence after surgery

A scanning electron microscope image of a gel developed by UCLA researchers that could help prevent cancer from recurring after surgery

Many people who are diagnosed with cancer will undergo some type of surgery to treat their disease — almost 95 percent of people with early-diagnosed breast cancer will require surgery and it’s often the first line of treatment for people with brain tumors, for example. But despite improvements in surgical techniques over the past decade, the cancer often comes back after the procedure.

Now, a UCLA-led research team has developed a spray gel embedded with immune-boosting drugs that could help. In a peer-reviewed study, the substance was successful half of the time in awakening lab animals’ immune systems to stop the cancer from recurring and inhibit it from spreading to other parts of the body.

A paper describing the work is published online in the journal Nature Nanotechnology.

The researchers, led by Zhen Gu, a professor of bioengineering at the UCLA Samueli School of Engineering and member of the UCLA Jonsson Comprehensive Cancer Center, tested the biodegradable spray gel in mice that had advanced melanoma tumors surgically removed. They found that the gel reduced the growth of the tumor cells that remained after surgery, which helped prevent recurrences of the cancer: After receiving the treatment, 50 percent of the mice survived for at least 60 days without their tumors regrowing.

The spray not only inhibited the recurrence of tumors from the area on the body where it was removed, but it also controlled the development of tumors in other parts of the body, said Gu, who is also a member of the California NanoSystems Institute at UCLA.

The substance will have to go through further testing and approvals before it could be used in humans. But Gu said that the scientists envision the gel being applied to the tumor resection site by surgeons immediately after the tumor is removed during surgery.

“This sprayable gel shows promise against one of the greatest obstacles in curing cancer,” Gu said. “One of the trademarks of cancers is that it spreads. In fact, around 90 percent of people with cancerous tumors end up dying because of tumor recurrence or metastasis. Being able to develop something that helps lower this risk for this to occur and has low toxicity is especially gratifying.”

The researchers loaded nanoparticles with an antibody specifically targeted to block CD47, a protein that cancer cells release as a “don’t-eat-me” signal. By blocking CD47, the antibody enables the immune system to find and ultimately destroy the cancer cells.

The nanoparticles are made of calcium carbonate, a substance that is the main component of egg shells and is often found in rocks. Researchers chose calcium carbonate because it can be gradually dissolved in surgical wound sites, which are slightly acidic, and because it boosts the activity of a type of macrophage that helps rid the body of foreign objects, said Qian Chen, the study’s lead author and a postdoctoral researcher in Gu’s lab.

“We also learned that the gel could activate T cells in the immune system to get them to work together as another line of attack against lingering cancer cells,” Chen said.

Once the solution is sprayed on the surgical site, it quickly forms a gel embedded with the nanoparticles. The gel helps stop at the surgical site and promotes would healing; the nanoparticles gradually dissolve and release the anti-CD47 antibodies into the body.

The researchers will continue testing the approach in animals to learn the optimal dose, best mix of nanoparticles and ideal treatment frequency, before testing the gel on human patients.

Learn more: Sprayable gel developed by UCLA-led team could help the body fight off cancer after surgery

See Also



The Latest on: Biodegradable spray gel

[google_news title=”” keyword=”biodegradable spray gel” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]

via Google News


The Latest on: Biodegradable spray gel
  • 31 Cleaning Products Reviewers Call “Powerful”
    on May 26, 2024 at 1:00 pm

    A drill brush kit for putting the elbow grease into cleaning without making you work twice as hard. These attachments fit onto your drill and add extra power behind the scrub brushes to tackle bigger ...

  • The 6 Best Eco Friendly Laundry Detergents of 2024
    on May 24, 2024 at 11:35 am

    Laundry pods, less messy and bulky than liquid detergents, have become a familiar concept in recent years. Dropps pods set themselves apart from other brands, focusing on sustainability and ...

  • Is Biodegradable Plastic Really a Thing?
    on May 19, 2024 at 5:00 pm

    Technically, it exists. But here’s what to think about when shopping. Credit...Naomi Anderson-Subryan Supported by By Hiroko Tabuchi On the face of it, biodegradable plastic is a miracle.

  • Biodegradable Gel Prevents Tumor Metastasis After Surgery (IMAGE)
    on May 19, 2024 at 2:46 am

    A biodegradable hydrogel representing those used in the study. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing ...

  • The 5 best sunscreens to slather on this summer
    on May 17, 2024 at 11:05 am

    With the aim of finding a suitable sunscreen formula for pretty much every preference, we’ve rounded up five best sunscreens to slather on this summer. From a full-body find to a one-and-done ...

  • 14 Best Ant Killers for Your Home and Yard
    on May 5, 2024 at 5:00 pm

    Insert the gel into cracks ... treating an area. Using biodegradable D-Limonene (orange peel oil) as its active ingredient, premixed Orange Guard Home Pest Control Spray not only kills ants ...

  • Biodegradable 'living plastic' houses bacterial spores that help it break down
    on April 29, 2024 at 5:00 pm

    Researchers have developed a biodegradable form of thermoplastic polyurethane (TPU) filled with bacterial spores that, when exposed to nutrients present in compost, germinate and break down the ...

  • ZONE3 launches world’s first biodegradable wetsuit
    on February 20, 2024 at 4:00 pm

    ZONE3 is renowned for its high quality triathlon wetsuits and now the brand has taken things a step further with sustainability at the forefront, releasing the first ever biodegradable wetsuit.

  • New biodegradable gel could repair damage caused by heart attack
    on June 7, 2022 at 11:48 pm

    This is a biodegradable gel which can be directly injected into a beating heart which works as a scaffold for injected cells to grow new tissue. Experts at the University of Manchester ...

via  Bing News


What's Your Reaction?
Don't Like it!
I Like it!
Scroll To Top