If it burns in a house smoke detectors alert us hence protecting life. A molecular smoke alert has now been developed by Dresden researchers for the TP53 gene, the most important human cancer gene. The alert goes on if the TP53 gene is mutated in cells. The molecular smoke detector works like a TP53 sensor, which monitors the correct function of the gene. A non-functional TP53 gene is going to activate the sensor, which initiates cell death.
Results from this study from the research team of Prof. Frank Buchholz are now published in the journal Nature Communications.
Cancer is caused by changes in the human genome. Mutations in oncogenes and in tumor suppressor genes accumulate unrecognized over time and lead to uncontrolled cell proliferation eventually. In 50% of all human tumors the tumor suppressor gene TP53 is no longer functional being the most frequently mutated cancer gene. TU Dresden-Scientists from the University Cancer Center UCC at the University Hospital Carl Gustav Carus, the National Center for Tumor Diseases NCT Dresden and the German Cancer Consortium DKTK Dresden concluded that the formation of a TP53 sensor could suppress tumor formation at a very early stage.
To achieve this they designed a genetic element that makes cell function dependent on normal TP53. If the TP53 function is interrupted, the sensor gets activated and initiates cell death. “We treat cancer cells long after they have gone through the transformation process,” says Prof. Dr. Frank Buchholz describing the current situation. As a result, therapy is often too late to be able to eliminate all cancer cells in the body. Furthermore, due to additional mutations, therapy-resistant clones quickly emerge from some cancer cells.
“The TP53 sensor enables an active precocious intervention for the first time. Our results show that cells with TP53 mutations can be selectively detected and eliminated at an early stage. Hence, the transformation process is prevented.” The researchers plan to use their initial findings to develop new cancer diagnostics and to establish a protection system against cancer mutations in the long-term.
Learn more: Dresden scientists develop a sensor for the most important human cancer gene
The Latest on: TP53 sensor
[google_news title=”” keyword=”TP53 sensor” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
- TP53-Mutated MDS/AML Posttransplant Treatment Gapson April 10, 2024 at 5:00 pm
Outcomes of patients with TP53-mutated myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) remain negative despite the utilization of allogeneic hematopoietic stem cell transplant ...
- HomeKit Weekly: Aqara releases new HomeKit-compatible motion and light sensor with Thread supporton April 10, 2024 at 5:00 am
They’ve released a new motion and light sensor called the Aqara Motion and Light Sensor P2. HomeKit Weekly is a series focused on smart home accessories, automation tips and tricks, and everythi ...
- Aqara’s best presence sensor just got even betteron April 8, 2024 at 5:00 pm
This presence sensor has been an impressive piece of kit ever since it was released, but just recently has gotten even better The Aqara FP2 is an mmWave presence sensor. It is capable of multiple ...
- Study: Cancer genomic profiles differ in Japan, U.S. patientson April 5, 2024 at 12:00 am
A study released by the National Cancer Center Japan has revealed higher rates of mutations in a tumor-suppressing gene, TP53, in Japanese cancer patients compared to those in the United States.
- How to Clean A Mass Air Flow Sensoron March 1, 2024 at 1:53 am
With disposable towels, wipe away any loose dirt or dust from the MAF sensor, as well as all air ducts. Take your time removing the sensor. Parts are plastic. They become brittle over time and can ...
- capacitive sensoron November 27, 2023 at 4:00 pm
[Magnus] pairs the off-the-shelf capacitive sensor with an ESP32 charged with reading it and reporting back to Home Assistant. It’s also outfitted with a heater to keep it at a constant ...
- pH sensoron September 30, 2023 at 5:01 pm
Like swimming pools, hot tubs need regular monitoring to ensure their water stays clean and clear. An average person might take a water quality reading once or twice a week using test strips, but ...
- Fuel Tank Pressure Sensoron January 28, 2022 at 12:22 am
The fuel tank pressure sensor is part of the fuel pump assembly and is mounted on top of the tank or inside the tank. It’s part of the evaporative emissions system (commonly referred to as ...
- Kinect Sensor not detected on Windows PCon May 11, 2020 at 10:30 am
If after you upgrade the operating system on a Surface Book, or any other Windows 11/10-powered device, and you’re unable to use the Kinect for Windows Sensor on the device, then this post is ...
- MAP Sensoron April 9, 2015 at 4:15 am
The manifold absolute pressure sensor reads the amount of pressure or vacuum (also called “engine load”) in the intake manifold, where outside air is divvied up in proper amounts and ...
via Google News and Bing News