The results suggest the technique could be used to combat a variety of diseases.
Using a novel form of immune-genetic therapy, researchers from Yale School of Medicine and the Jagiellonian University College of Medicine in Poland have successfully inhibited a strong immune allergic inflammatory response in the skin of mice. The results suggest the technique could be used to combat a variety of diseases.
“We use an antibody coating we chose to deliver therapeutic genetic material we selected to target cells,” said Dr. Philip Askenase, professor of medicine and senior author of the study published July8 in the Journal of Allergy and Clinical Immunology.
The delivery system consists of naturally occurring nanoparticles called exosomes that are about one thousandth the size of donor cells that release them. These tiny vesicles were once thought to contain only unneeded cellular debris. However, in the last decade, scientists have shown that there are billions of exosomes in the circulation and that they carry genetic instructions in the form of micro-RNAs (miRNA) to regulate the functions of nearby and distant cells.
Askenase and colleagues found that exosomes could be coated with an antibody of their choosing. These nanovesicles were able to deliver therapeutic miRNA to specific cells targeted by the antibody. In the current study, the coated exosomes delivered their miRNA cargo to immune system cells, inhibiting an active allergic disease response in the skin of mice.
“These natural nanoparticles are present throughout the body,” said Dr. Krzysztof Bryniarski of Jagiellonian University and lead author of the paper. “They seem to be a superior delivery system compared to artificial nanoparticles currently in use, which often are eliminated from the body because they are sensed as artificial.”
The Latest Bing News on:
Nature’s own nanoparticles
- Nanotubes, nanoparticles, and antibodies detect tiny amounts of fentanylon May 9, 2024 at 10:32 am
A research team has developed a fentanyl sensor that is six orders of magnitude more sensitive than any electrochemical sensor for the drug reported in the past five years. The portable sensor can ...
- Researchers develop a nanoparticle that can penetrate the blood-brain barrieron May 6, 2024 at 12:00 pm
Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have developed a nanoparticle that can penetrate the blood-brain barrier. Their goal is to ...
- How To Host Your Own Website (2024 Guide)on May 4, 2024 at 9:34 am
Commissions do not affect our editors' opinions or evaluations. As advanced as it may initially sound, anyone can host their own site. Doing so will not only save you money, but it will also give ...
- Scientists reveal nanoparticle that can treat Alzheimer’s disease in miceon April 30, 2024 at 5:00 pm
(CN) — A milestone in Alzheimer’s disease research emerged Wednesday as scientists revealed an improved magnetic nanoparticle that alleviated the biological and behavioral symptoms of Alzheimer’s in ...
- First high-resolution 3D nanoscale chemical imaging achieved with multi-modal tomographyon April 30, 2024 at 6:21 am
By exploiting a smart learning algorithm that fuses two microscopy signals, University of Michigan researchers have accomplished high-resolution, efficient 3D chemical imaging for the first time at ...
- NATURE'S OWN DEBUTS FOUR NEW PRODUCTS TO INSPIRE CULINARY CREATIVITYon April 23, 2024 at 8:21 am
THOMASVILLE, Ga., April 23, 2024 /PRNewswire/ -- Nature's Own®, America's No. 1 selling bread brand, has unveiled its latest lineup of innovative products, arriving just in time for summer and ...
- NATURE'S OWN DEBUTS FOUR NEW PRODUCTS TO INSPIRE CULINARY CREATIVITYon April 23, 2024 at 4:21 am
April 23, 2024 /PRNewswire/ -- Nature's Own ®, America's No. 1 selling bread brand, has unveiled its latest lineup of innovative products, arriving just in time for summer and grilling season: Keto ...
- Nature Now Has Its Own Spotify Artist Page: Initiative Will Raise Conservation Funds With Music by David Bowie, Brian Eno & Moreon April 17, 2024 at 5:00 pm
By Katie Bain Many songs from across the musical canon feature the sound of ocean waves, wind, rain, thunder, lightning, bird calls and other sounds of nature. Now, nature itself is being ...
The Latest Google Headlines on:
Nature’s own nanoparticles
[google_news title=”” keyword=”Nature’s own nanoparticles” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
The Latest Bing News on:
Immune-genetic therapy
- Cancer Vaccine Triggers Fierce Immune Response to Fight Malignant Brain Tumors in Human Patientson May 11, 2024 at 6:37 am
In the first human trial, an mRNA cancer vaccine at the University of Florida triggered immune systems to fiercely attack glioblastoma.
- Direct measurement of the interaction between immune cells and cancer cells from a patient's biopsyon May 10, 2024 at 10:24 am
Researchers have unveiled a technology that promises to improve cancer treatment decisions based on a patient's biopsy. The pioneering biological research and development measures changes in immune ...
- Can HIV be cured using gene editing? We will soon find outon May 10, 2024 at 7:30 am
We will have to wait till 2024 for the first report on efficacy. Despite the availability of antiretroviral drugs, hundreds of thousands of people still die from Aids each year. A cure for the disease ...
- Research finds genetic variation that could lead to increased risk of viral infectionson May 9, 2024 at 11:44 am
The research, published May 8 in Blood, suggests that new drugs that target these immune system mechanisms could improve the treatment of viral infections ... To discover whether people with this ...
- The doctor behind the next big thing in cancer treatmenton May 9, 2024 at 10:36 am
Dr Catherine Wu’s research has laid the scientific foundation for the development of cancer vaccines that are tailored to the genetic makeup of an individual’s tumor. It’s a strategy that is looking ...
- New mRNA vaccine for deadly brain cancer triggers a strong immune responseon May 9, 2024 at 4:00 am
The vaccine, which was described in a study published on May 1 in the journal Cell, was created by extracting genetic material called RNA from ... And by the time immune therapy begins, “the cancer is ...
- Interferon beta corrects gene processing disrupted in MS: Studyon May 8, 2024 at 10:01 pm
Interferon beta corrected defects in a process known as alternative splicing, which is disrupted in MS, a study found.
- Cell therapy fails to slow early type 1 diabetes, but safety is establishedon May 8, 2024 at 11:00 am
Despite the negative finding, researchers said there is still promise in the strategy of amplifying and infusing the immune cells of newly diagnosed type 1 diabetes patients.
- Immune cell discovery ‘could lead to personalised treatment for breast cancer’on May 7, 2024 at 10:32 pm
“This will allow us to develop anti-cancer antibody treatments similar to the ones the B cells produce, which can then be given as a personalised treatment ... and identified genetic variations in the ...
- ASGCT Preview: Mingozzi and Keeler Discuss the State of Gene Therapyon May 3, 2024 at 11:00 am
Federico Mingozzi, PhD, joins Allison Keeler, PhD, on GEN Live to discuss the state of gene therapy and what they are looking forward to at the ASGCT meeting in May.
The Latest Google Headlines on:
Immune-genetic therapy
[google_news title=”” keyword=”immune-genetic therapy” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]