Illustration of microrobots entering the lungs to treat pneumonia.
Credit: Wang lab/UC San Diego
Nanoengineers at the University of California San Diego have developed microscopic robots, called microrobots, that can swim around in the lungs, deliver medication and be used to clear up life-threatening cases of bacterial pneumonia.
In mice, the microrobots safely eliminated pneumonia-causing bacteria in the lungs and resulted in 100% survival. By contrast, untreated mice all died within three days after infection.
The results are published Sept. 22 in Nature Materials.
The microrobots are made of algae cells whose surfaces are speckled with antibiotic-filled nanoparticles. The algae provide movement, which allows the microrobots to swim around and deliver antibiotics directly to more bacteria in the lungs. The nanoparticles containing the antibiotics are made of tiny biodegradable polymer spheres that are coated with the cell membranes of neutrophils, which are a type of white blood cell. What’s special about these cell membranes is that they absorb and neutralize inflammatory molecules produced by bacteria and the body’s immune system. This gives the microrobots the ability to reduce harmful inflammation, which in turn makes them more effective at fighting lung infection.
The work is a joint effort between the labs of nanoengineering professors Joseph Wang and Liangfang Zhang, both at the UC San Diego Jacobs School of Engineering. Wang is a world leader in the field of micro- and nanorobotics research, while Zhang is a world leader in developing cell-mimicking nanoparticles for treating infections and diseases. Together, they have pioneered the development of tiny drug-delivering robots that can be safely used in live animals to treat bacterial infections in the stomach and blood. Treating bacterial lung infections is the latest in their line of work.
“Our goal is to do targeted drug delivery into more challenging parts of the body, like the lungs. And we want to do it in a way that is safe, easy, biocompatible and long lasting,” said Zhang. “That is what we’ve demonstrated in this work.”
The team used the microrobots to treat mice with an acute and potentially fatal form of pneumonia caused by the bacteria Pseudomonas aeruginosa. This form of pneumonia commonly affects patients who receive mechanical ventilation in the intensive care unit. The researchers administered the microrobots to the lungs of the mice through a tube inserted in the windpipe. The infections fully cleared up after one week. All mice treated with the microrobots survived past 30 days, while untreated mice died within three days.
Treatment with the microrobots was also more effective than an IV injection of antibiotics into the bloodstream. The latter required a dose of antibiotics that was 3000 times higher than that used in the microrobots to achieve the same effect. For comparison, a dose of microrobots provided 500 nanograms of antibiotics per mouse, while an IV injection provided 1.644 milligrams of antibiotics per mouse.
The team’s approach is so effective because it puts the medication right where it needs to go rather than diffusing it through the rest of the body.
“These results show how targeted drug delivery combined with active movement from the microalgae improves therapeutic efficacy,” said Wang.
“With an IV injection, sometimes only a very small fraction of antibiotics will get into the lungs. That’s why many current antibiotic treatments for pneumonia don’t work as well as needed, leading to very high mortality rates in the sickest patients,” said Victor Nizet, professor at UC San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences, who is a co-author on the study and a physician-scientist collaborator of Wang and Zhang. “Based on these mouse data, we see that the microrobots could potentially improve antibiotic penetration to kill bacterial pathogens and save more patients’ lives.”
And if the thought of putting algae cells in your lungs makes you squeamish, the researchers say that this approach is safe. After treatment, the body’s immune cells efficiently digest the algae, along with any remaining nanoparticles. “Nothing toxic is left behind,” said Wang.
The work is still at the proof-of-concept stage. The team plans to do more basic research to understand exactly how the microrobots interact with the immune system. Next steps also include studies to validate the microrobot treatment and scaling it up before testing it in larger animals and eventually, in humans.
“We’re pushing the boundary further in the field of targeted drug delivery,” said Zhang.
Original Article: Tiny Swimming Robots Treat Deadly Pneumonia in Mice
More from: University of California San Diego | Jacobs School of Engineering
The Latest Updates from Bing News
Go deeper with Bing News on:
Targeted drug delivery
- Judge defers imprisonment to allow convicted cocaine delivery man attend child’s Communion
A judge has granted a request by a convicted cocaine delivery man and “decent family man” to defer his imprisonment to allow him attend his child’s First Holy Communion tomorrow.
- Plus Therapeutics Announces New Employment Inducement Grants
Combining image-guided local beta radiation and targeted drug delivery approaches, the Company is advancing a pipeline of product candidates with lead programs in recurrent glioblastoma (GBM) and ...
- GLP-1 and NMDA Targeted Weight-Loss Drug Shows Promise
Researchers have developed a novel weight-loss drug that combines GLP-1 with molecules targeting NMDA receptors in the brain.
- Biora Therapeutics Provides Corporate Update and Reports First Quarter 2024 Financial Results
Dosing of all patients in clinical trial of BT-600 has been successfully completed, with results anticipated in late Q2 2024Clinical data on ...
- Key advantages of using biodegradable microspheres as targeted drug delivery systems
Biodegradable microspheres are new, targeted drug delivery systems that are becoming increasingly popular in the field of drug design. A key characteristic among the various advantages of ...
Go deeper with Bing News on:
Nano factory
- Lok Sabha elections: In Singur, Lakshmir Bhandar in the spotlight
In a state where big-ticket investments have become rare, Mamata Banerjee's numerous welfare schemes are fulfilling needs in more ways than one ...
- The new classic Nokia 3210 (2024) 4G gets sold out in its first sale
Nokia, via its official Weibo handle, stated that all major warehouses are currently out of stock and the factory is in full production ... It has a built-in Nano SIM card slot with support for some ...
- Google Shows Off Android 15's 2 New Privacy Tools. Here's How They'll Work
The current Android 15 beta release brings other new features that are available to use right now, like more in-app camera controls, improved large-screen multitasking, richer widget previews, partial ...
- PyroGenesis Announces 2024 First Quarter Results
PyroGenesis recorded revenue of $3.5 million in the first quarter of 2024 (“Q1, 2024”), representing an increase of $0.9 million compared with $2.6 million recorded in the first quarter of 2023 (“Q1, ...
- Tweaked Mercedes-AMG GT 63 S Proves Less Is Often More in the Tuning World
Although we were never fans of the Mercedes-AMG GT 4-Door Coupe's styling, this one deserves your attention. Do you dig the spec?