Close analysis of EEG data reveals that nearly 1 in 7 brain-injured ICU patients shows evidence of hidden consciousness just days after injury. Patients with such signs are more likely to recover, neurologists at Columbia University and NewYork-Presbyterian have found.
In the study, the researchers used a machine learning technique to analyze standard EEG data collected from 104 unresponsive patients to look for patient-specific brain activity indicating that they could understand instructions to move their hands. If the findings are confirmed in larger studies, the technique could help physicians better predict which patients will likely regain consciousness.
“Though our study was small, it suggests that EEG—a tool that’s readily available at the patient’s bedside in the ICU in almost any hospital across the globe—has the potential to completely change how we manage patients with acute brain injury,” says Jan Claassen, MD, PhD, associate professor of neurology at Columbia University Vagelos College of Physicians and Surgeons, lead author of the study, and director of the Neurological Intensive Care Unit at NewYork-Presbyterian/Columbia University Irving Medical Center.
The findings were published today in the New England Journal of Medicine.
Why It’s Important
Currently, there’s no perfect way to accurately predict the chance of recovery for unconscious, brain-injured patients.
Electroencephalography (EEG) is commonly used in intensive care to monitor critically ill patients at risk for seizures and may be a relatively easy and fast way to identify signs of hidden consciousness in unresponsive patients who have recently experienced brain injury.
Background
Difficult discussions between families and health care providers determine the intensity of medical support for unresponsive patients. The decision to withdraw life-sustaining therapies from patients who appear to have little chance to recover are frequently made within the first weeks following brain injury.
Clinicians use bedside neurological examinations, imaging and electrophysiological studies, and laboratory values to estimate the likelihood of recovery for people who are unresponsive in the days and weeks after sustaining a brain injury. However, these predictions are frequently inaccurate.
Increasingly, however, studies suggest that some unresponsive patients may have hidden cognitive abilities and that delayed recovery is more common than previously thought.
Hidden consciousness was first identified over a decade ago using MRI in a brain-injured patient who had been unresponsive for years. Since then, studies using MRI or EEG have detected signs of hidden consciousness in 14% of chronically unresponsive patients. But MRI is challenging to perform in a critical care setting.
“One of the most challenging problems in the ICU involves predicting recovery, and not just survival, for patients who are unconscious after a brain injury,” says Claassen. “Since the first studies describing hidden consciousness, we’ve been looking for a practical way to do this in the early days after brain injury, when treatment decisions that affect outcomes are often made.”
What the Researchers Did
Claassen and his team studied 104 adult patients in an intensive care unit who had recently sustained a sudden brain injury due to hemorrhage, trauma, or oxygen deprivation. Though none of the patients were paralyzed, they were unable to talk and did not respond to commands to move (e.g., make a fist or wiggle their toes).
Every day, in addition to standard neurological exams, the patients were asked multiple times to open and close their hands or stop opening and closing their hands. A complex algorithm was used to analyze EEG data from these sessions to look for signs that a patient detected a difference between the commands. A reproducibly different pattern of activity between the commands suggested that a patient was able to understand the command but could not perform the movement.
The researchers followed up with patients who were discharged from the hospital a year later.
What the Study Found
Within four days of the injury, 15% of the still-unresponsive patients had brain activity patterns on at least one EEG recording, suggesting hidden consciousness. Among the patients with these patterns, 50% improved and were able to follow verbal commands before being discharged from the hospital versus 26% of those without such brain activity.
A year later, 44% of patients with brain activity patterns were able to function independently for up to eight hours each day, compared with only 14% of those without such signals. Approximately one-third of patients in each group—those with early EEG evidence of hidden consciousness and those without—died.
Hidden consciousness signals were also more common in patients with brain injuries from hemorrhage and trauma than from oxygen deprivation. However, the study lacked sufficient statistical power to determine the predictive value of EEG analysis across different causes of brain injury.
“This study shows that some patients who are unresponsive for days or longer may have cognitive processing capabilities sufficient to distinguish commands, and those patients have a higher chance of recovering,” says Claassen.
Caveats
Bigger studies—especially in patients with a single cause of brain injury—are needed to determine the utility of EEG monitoring in predicting patient outcomes.
There are some technical challenges with EEG monitoring: Neurological exams must be performed at least once or twice a day as consciousness fluctuates after a brain injury; spoken commands must be highly synchronized with EEG recordings; and additional computers are needed to do the analysis.
“It’s important to begin monitoring with EEG as early as possible and to assess at several time points as recovery after a severe brain injury is a complex process,” Claassen says.
Most importantly, he says, these assessments have to be designed meticulously because artifacts may be misinterpreted as brain activation if the testing paradigm is poorly designed or the computational analysis is applied incorrectly.
Learn more: Hidden Consciousness Detectable with EEG Just Days after Brain Injury
The Latest on: Brain injury
[google_news title=”” keyword=”brain injury” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Brain injury
- Mike Tyson 'at risk' of brain injury as boxing icon prepares for upcoming Jake Paul fighton May 13, 2024 at 1:46 am
A concussion expert has warned Mike Tyson that he's at risk of a brain injury ahead of his fight with Jake Paul later this year. Iron Mike will be returning to the sport after a four-year absence, ...
- Family looking for answers to Beechmont homicideon May 12, 2024 at 11:45 pm
Among the victims of weekend of violence was 18-year-old David “Dee” Martinez, whose family said he was found shot along railroad tracks in the Beechmont neighborhood last night.
- Four jailed over ‘nightmarish’ Co. Antrim attack and kidnapping that left victim with brain injuryon May 12, 2024 at 2:27 am
FOUR men have been jailed for their role in a brutal attack and kidnapping that left the victim with a permanent brain injury. David Cherry, Glen Sheridan, Mark Bradshaw and Sean Davies appeared ...
- 'Walking miracle:' Mount Pleasant mother, nurse back after brain injury and rehabon May 12, 2024 at 2:00 am
Summerville nurse and mother who suffered a brain injury after an accident is back at work in Mount Pleasant hospital and appreciates Mother's Day this year.
- Brain Injury Alliance of Kentucky raises awareness through Run, Walk and Roll eventon May 11, 2024 at 1:59 am
The Brain Injury Alliance of Kentucky brought together hundreds of brain injury survivors for its Run, Walk and Roll 5K.
- Back from traumatic brain injury, Windsor's Jake Eccleston again wins two 4A swimming titleson May 10, 2024 at 9:42 pm
The Windsor senior completed a remarkable comeback story after a traumatic brain injury, winning two 4A state titles and earning Swimmer of the Year honors.
- NFL wants out of brain injury lawsuit involving ex-player who killed 6 in Rock Hillon May 10, 2024 at 5:21 pm
The NFL now wants out of a brain injury lawsuit filed by the family of former player Phillip Adams, who deputies say killed six people near Rock Hill in 2021 before killing himself, federal court ...
- Traumatic brain injury survivor earns art exhibit at Stockton Universityon May 10, 2024 at 1:56 pm
A skateboarding accident left Maryn Skylar Olson fighting for her life. Since then, she has used the power of art to overcome her challenges.
- 'My drink was spiked - now I have a brain injury'on May 10, 2024 at 10:52 am
A woman from Bristol is suffering from a brain injury after a suspected drink spiking incident on a night out. Within a few hours of Simone White, 43, going out with friends, she started to feel "very ...
- Some brain tumors may be linked to head injury, mouse study suggestson May 9, 2024 at 9:27 am
A study in mice by researchers at the School of Medicine indicates that brain injury can lead to brain tumors in susceptible individuals. For this study, they used mice that model people with ...
via Bing News